In vitro lymphocyte proliferation with milk and a casein–whey protein hydrolyzed formula in children with cow's milk allergy

1995 ◽  
Vol 96 (4) ◽  
pp. 549-557 ◽  
Author(s):  
P EIGENMANN ◽  
D BELLI ◽  
F LUDI ◽  
J KAHN ◽  
B POLLA
Keyword(s):  
Whey Protein ◽  
Lymphocyte Proliferation ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Hydrolyzed Formula

scholarly journals Hypoallergenicity of a thickened hydrolyzed formula in children with cow’s milk allergy

2019 ◽  
Vol 7 (16) ◽  
pp. 2256-2268
Author(s):  
Danilo Rossetti ◽  
Salvatore Cucchiara ◽  
Alessandra Morace ◽  
Beatrice Leter ◽  
Salvatore Oliva
Keyword(s):  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Hydrolyzed Formula

Rapid and sensitive detection of cow's milk allergy by in vitro basophil acitvation

2002 ◽  
Vol 109 (1) ◽  
pp. S215-S215
Author(s):  
Bernard Arnoux ◽  
Monique Rongier ◽  
Satomi Kamei ◽  
Jean Bousquet ◽  
Jacques De Blic
Keyword(s):  
Cow’S Milk Allergy ◽  
Sensitive Detection ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy

scholarly journals A Preterm Case of Cow’s Milk Allergy Presenting with Recurrent Ascites Treated with Donor Breast Milk

2021 ◽  
Vol 18 (3) ◽  
pp. 1187
Author(s):  
Ruka Nakasone ◽  
Kazumichi Fujioka ◽  
Shutaro Suga ◽  
Shinya Abe ◽  
Mariko Ashina ◽  
...  
Keyword(s):  
Breast Milk ◽  
Male Infant ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Hydrolyzed Formula ◽  
Mother’S Own Milk ◽  
Milk Feeding

We report a case of a preterm infant who developed cow’s milk allergy. This male infant presented with recurrent ascites and was successfully treated with donated breast milk. He was born at 24 weeks’ gestation with a birthweight of 506 g. From day 20, infant formula, soy protein-based formula, and casein-hydrolyzed formula were used due to insufficient maternal lactation. This resulted in abdominal distention, generalized edema, and recurrent ascites. We diagnosed him with cow’s milk allergy since these symptoms improved on exclusive breast milk feeding. No recurrence of symptoms occurred when donated breast milk was used in combination with the mother’s own milk. Ascites should be regarded as a clinical symptom of neonatal cow’s milk allergy. Donated breast milk may be effective in the treatment of the allergy if breastfeeding is not available.

scholarly journals Systemic reaction to an extensively hydrolyzed formula in an infant with cow’s milk anaphylaxis

2020 ◽  
Vol 2 (2) ◽  
pp. 164-167
Author(s):  
Alvaro Flores ◽  
Yudy K. Persaud
Keyword(s):  
Systemic Reaction ◽  
Signs And Symptoms ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Protein Chain ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Hydrolyzed Formula

Background: Cow’s milk allergy is the most common cause of food allergy in young children. Ingestion of milk products in children with a milk protein allergy can lead to anaphylaxis and must be avoided. Some guidelines suggest the use of an extensively hydrolyzed formula (EHF) in these cases; however, rare allergic reactions can still occur. Here, we presented a 3-month-old boy who developed anaphylaxis to a cow’s milk formula. Subsequently, he developed a rare systemic reaction to soy and to an EHF. Case: The patient had an unremarkable medical history and presented with signs and symptoms consistent with anaphylaxis after being fed cow’s milk formula for the first time. Symptoms included immediate vomiting, wheezing, stridor, angioedema of eyelids and lips. Although intramuscular epinephrine was given, the patient continued to clinically deteriorate, becoming more lethargic and necessitating admission to the pediatric intensive care unit. Subsequently, a trial of soy formula ingestion reproduced the symptoms and an EHF was given. However, immediately after taking an EHF, he developed facial angioedema and diffuse urticarial lesions. Conclusion: In most patients with a cow’s milk allergy, an extensively based formula can be tolerated safely due to a hydrolyzed protein chain. However, medical providers must be vigilant when switching formula because a rare systemic allergic reaction to EHF can still occur.

Most cases of cow's milk allergy are able to ingest a partially hydrolyzed formula

2015 ◽  
Vol 115 (4) ◽  
pp. 330-331.e2 ◽  
Author(s):  
Jun Kido ◽  
Natsuko Nishi ◽  
Masami Sakaguchi ◽  
Tomoaki Matsumoto
Keyword(s):  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Hydrolyzed Formula

scholarly journals Cow’s milk allergy in patients with diarrhea

2016 ◽  
Vol 44 (6) ◽  
pp. 239 ◽  
Author(s):  
Nanis S Marzuki ◽  
Arwin AP Akib ◽  
I Boediman
Keyword(s):  
Acute Diarrhea ◽  
Chronic Diarrhea ◽  
Elimination Diet ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Hydrolyzed Formula

Background Cow’s milk allergy (CMA) might be one of the causesof diarrhea in children. Previous prospective studies found theprevalence of CMA in children aged 0-3 years between 1.1-5.2%,but data about the prevalence of CMA in children with diarrheawas very limited.Objective This study intended to estimate the prevalence of CMAin children with diarrhea.Methods Children aged 0-3 years, who came with diarrhea andconsumed milk formula were selected for further evaluation. Adiagnostic procedure was developed i.e., elimination diet with par-tially hydrolyzed formula (pHF) for 2 weeks, and then open milkchallenge. If diarrhea was not resolved with pHF, the children weregiven extensively hydrolyzed formula, or soy-based formula.Results Ninety-nine children participated in this study, 87 camewith acute diarrhea and 12 with chronic diarrhea. There were 3children (2 children with acute diarrhea and one with chronicdiarrhea) who reacted to the milk challenge.Conclusion The estimated prevalence of CMA in children withdiarrhea in our study was 3%

scholarly journals Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2479
Author(s):  
Xiaoli Zhao ◽  
Suzan Thijssen ◽  
Hongbing Chen ◽  
Johan Garssen ◽  
Leon M. J. Knippels ◽  
...  
Keyword(s):  
Mast Cell ◽  
Food Allergy ◽  
Whey Protein ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Control Group ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Increased Risk

Cow’s milk allergy is a common food allergy in infants, and is associated with an increased risk of developing other allergic diseases. Dietary selenium (Se), one of the essential micronutrients for humans and animals, is an important bioelement which can influence both innate and adaptive immune responses. However, the effects of Se on food allergy are still largely unknown. In the current study it was investigated whether dietary Se supplementation can inhibit whey-induced food allergy in an animal research model. Three-week-old female C3H/HeOuJ mice were intragastrically sensitized with whey protein and cholera toxin and randomly assigned to receive a control, low, medium or high Se diet. Acute allergic symptoms, allergen specific immunoglobulin (Ig) E levels and mast cell degranulation were determined upon whey challenge. Body temperature was significantly higher in mice that received the medium Se diet 60 min after the oral challenge with whey compared to the positive control group, which is indicative of impaired anaphylaxis. This was accompanied by reductions in antigen-specific immunoglobulins and reduced levels of mouse mast cell protease-1 (mMCP-1). This study demonstrates that oral Se supplementation may modulate allergic responses to whey by decreasing specific antibody responses and mMCP-1 release.

scholarly journals Allergen-responsive CD4+CD25+ Regulatory T Cells in Children who Have Outgrown Cow's Milk Allergy

2004 ◽  
Vol 199 (12) ◽  
pp. 1679-1688 ◽  
Author(s):  
Malin R. Karlsson ◽  
Jarle Rugtveit ◽  
Per Brandtzaeg
Keyword(s):  
T Cells ◽  
Treg Cells ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Dietary Antigens ◽  
Β Lactoglobulin

Cow's milk allergy in children is often of short duration, which makes this disorder an interesting clinical model for studies of tolerance to dietary antigens. Here, we studied T cell responses in 21 initially allergic children who, after a milk-free period of >2 mo, had cow's milk reintroduced to their diet. Children who outgrew their allergy (tolerant children) had higher frequencies of circulating CD4+CD25+ T cells and decreased in vitro proliferative responses to bovine β-lactoglobulin in peripheral blood mononuclear cells (PBMCs) compared with children who maintained clinically active allergy. No significant difference in proliferative activity stimulated by the polyclonal mitogen phytohemagglutinin was observed between the two groups. Depletion of CD25+ cells from PBMCs of tolerant children led to a fivefold increase in in vitro proliferation against β-lactoglobulin. This suggests that tolerance is associated with the appearance of circulating CD4+CD25+ regulatory T (Treg) cells that are capable of suppressing the effector T cells generated 1 wk after reintroduction of cow's milk. The suppressive function of the CD4+CD25+ Treg cells was shown to be partly cell contact dependent. Collectively, our study provides human data to suggest that mucosal induction of tolerance against dietary antigens is associated with the development of CD4+CD25+ Treg cells.

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