SURGICAL STIMULATION OF BONE GROWTH

The Lancet ◽  
1933 ◽  
Vol 221 (5711) ◽  
pp. 314-315
1986 ◽  
Vol &NA; (204) ◽  
pp. 303???312
Author(s):  
CLAUDE L. R. S. LAGEY ◽  
JAN M. M. ROELOFS ◽  
LUCAS W. M. JANSSEN ◽  
MARIEN BREEDIJK ◽  
REN?? H. F. LENTFERINK ◽  
...  

2014 ◽  
Vol 30 (13) ◽  
pp. 1590-1598 ◽  
Author(s):  
A. E. Markaki ◽  
A. W. Justin
Keyword(s):  

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Donghun Lee ◽  
Sung Hyun Lee ◽  
Yoon Hee Lee ◽  
Jungbin Song ◽  
Hocheol Kim

Astragalus extract mixture HT042 is a standardized ingredient of health functional food approved by Korean FDA with a claim of “height growth of children.” HT042 stimulates bone growth rate and increases local IGF-1 expression in growth plate of rats which can be considered as direct stimulation of GH and its paracrine/autocrine actions. However, it remains unclear whether HT042 stimulates circulatory IGF-1 which also plays a major role to stimulate bone growth. To determine the effects on circulatory IGF-1, IGF-1 and IGFBP-3 expressions and phosphorylation of JAK2/STAT5 were evaluated in the liver after 10 days of HT042 administration. HT042 upregulated liver IGF-1 and IGFBP-3 mRNA expression, IGF-1 protein expression, and phosphorylation of JAK2/STAT5. HT042 also increased bone growth rate and proliferative zonal height in growth plate. In conclusion, HT042 stimulates bone growth rate via increment of proliferative rate by upregulation of liver IGF-1 and IGFBP-3 mRNA followed by IGF-1 protein expression through phosphorylation of JAK2/STAT5, which can be regarded as normal functioning of GH-dependent endocrine pathway.


2010 ◽  
Vol 131 (3) ◽  
pp. 303-309 ◽  
Author(s):  
Joerg Hausdorf ◽  
Birte Sievers ◽  
Marcus Schmitt-Sody ◽  
Volkmar Jansson ◽  
Markus Maier ◽  
...  

1976 ◽  
Vol 10 (2) ◽  
pp. 231-247 ◽  
Author(s):  
Allan M. Weinstein ◽  
Jerome J. Kalwitter ◽  
Thomas W. Cleveland ◽  
Donald C. Amoss

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