The Effective Management and Outcome of Hand Burns

Burns is a common public health problem and these injuries can be accidental, suicidal or even homicidal in nature. Hands being the most active part of the body, are often involved in burns. Hand burns represent three percent of body surface area, and are involved in more than 80% of all severe burns. Hand burns predominantly affect young adults and therefore have serious social and financial implications. The hand is one of the most frequent sites of burns scar contracture deformity. The deformities and contractures result in lifelong physical problems and affects the normal functioning of the person.

Challenges in Treating Genodermatoses: New Therapies at the Horizon

Genodermatoses are rare inherited skin diseases that frequently affect other organs. They often have marked effects on wellbeing and may cause early death. Progress in molecular genetics and translational research has unravelled many underlying pathological mechanisms, and in several disorders with high unmet need, has opened the way for the introduction of innovative treatments. One approach is to intervene where cell-signaling pathways are dysregulated, in the case of overactive pathways by the use of selective inhibitors, or when the activity of an essential factor is decreased by augmenting a molecular component to correct disequilibrium in the pathway. Where inflammatory reactions have been induced by a genetically altered protein, another possible approach is to suppress the inflammation directly. Depending on the nature of the genodermatosis, the implicated protein or even on the particular mutation, to correct the consequences or the genetic defect, may require a highly personalised stratagem. Repurposed drugs, can be used to bring about a “read through” strategy especially where the genetic defect induces premature termination codons. Sometimes the defective protein can be replaced by a normal functioning one. Cell therapies with allogeneic normal keratinocytes or fibroblasts may restore the integrity of diseased skin and allogeneic bone marrow or mesenchymal cells may additionally rescue other affected organs. Genetic engineering is expanding rapidly. The insertion of a normal functioning gene into cells of the recipient is since long explored. More recently, genome editing, allows reframing, insertion or deletion of exons or disruption of aberrantly functioning genes. There are now several examples where these stratagems are being explored in the (pre)clinical phase of therapeutic trial programmes. Another stratagem, designed to reduce the severity of a given disease involves the use of RNAi to attenuate expression of a harmful protein by decreasing abundance of the cognate transcript. Most of these strategies are short-lasting and will thus require intermittent life-long administration. In contrast, insertion of healthy copies of the relevant gene or editing the disease locus in the genome to correct harmful mutations in stem cells is more likely to induce a permanent cure. Here we discuss the potential advantages and drawbacks of applying these technologies in patients with these genetic conditions. Given the severity of many genodermatoses, prevention of transmission to future generations remains an important goal including offering reproductive choices, such as preimplantation genetic testing, which can allow selection of an unaffected embryo for transfer to the uterus.

Development of functional caramel using system packages MathLab

The article presents substantiation for expanding the market for functional food products, in particular, confectionery - caramel. Proper nutrition is an integral part of a modern person diet; due to their properties, they increase the immunity and immune status of a person. The aim of the work is to create composite mixtures for sugar-free caramel using modern software. The studies were carried out using the MathLab software package, in particular the Statistica 10.0 software. A methodology for creating recipes using system packages has been developed. To enrich the caramel, the following components were selected: apple juice, coltsfoot extract, orange juice, mint and burdock extract, cranberry and lingonberry juices. An optimal recipe has been designed and equations are presented for calculating the dosages of the components of the enriched sugar-free caramel based on a natural sweetener isomalt with the addition of plant-based additives containing macro and micronutrients necessary for the normal functioning of the human body with a diagnosis of type II diabetes mellitus.

Do Bosses Get Bullied Too? A Qualitative Investigation of Causes, Impacts, and Treatments of Upward Workplace Bullying

Workplace bullying is an emerging problem in the organizational setting, that if not properly managed can deteriorate the normal functioning of an organization and consequently may harm the achievements of organizational goals. Aim of this research study is to explore the causes, impacts, and treatments of upward workplace bullying where subordinate behave in an inhumane way against supervisor. Data was collected by using semi-structured interviews with 10 persons employed at senior supervisory levels in the city of Faisalabad, Pakistan. A thematic analysis indicates that unclear managerial boundaries, absurd job descriptions, and weak interpersonal skills of the employees are the major causes of upward bullying. Individual impacts of bullying on the aggrieved parties and organizational treatments to mitigate and control the phenomenon are discussed.

Antioxidant for Neurological Diseases and Neurotrauma and Bioengineering Approaches

Antioxidants are a class of molecules with an innate affinity to neutralize reactive oxygen species (ROS), which are known to cause oxidative stress. Oxidative stress has been associated with a wide range of diseases mediated by physiological damage to the cells. ROS play both beneficial and detrimental roles in human physiology depending on their overall concentration. ROS are an inevitable byproduct of the normal functioning of cells, which are produced as a result of the mitochondrial respiration process. Since the establishment of the detrimental effect of oxidative stress in neurological disorders and neurotrauma, there has been growing interest in exploring antioxidants to rescue remaining or surviving cells and reverse the neurological damage. In this review, we present the survey of different antioxidants studied in neurological applications including neurotrauma. We also delve into bioengineering approaches developed to deliver antioxidants to improve their cellular uptake in neurological applications.

Copper Nanoparticles: Synthesis and Characterization, Physiology, Toxicity and Antimicrobial Applications

Metallic nanoparticles are a new class of materials with applications in medicine, pharmaceutical and agriculture. Using biological, chemical and physical approaches, nanoparticles with amazing properties are obtained. Copper is one of the most-found elements and plays an important part in the normal functioning of organisms. Coper nanoparticles have superior antibacterial properties when comparing them to present day antibiotics. Moreover, apart from their antibacterial role, antifungal, antiviral and anticancer properties have been described. Although the mechanism of actions is not completely understood, copper nanoparticles can become a viable alternative in fighting multi-resistant bacteria strains. We hereby review the already existing data on copper nanoparticle synthesis, effects and mechanisms of action as well as toxicity.

THE SURVEY OF THE MONUMENTAL FOUNTAIN IN THE TOWN OF DALMINE: A PRELIMINARY WORK FOR THE CONSERVATION PROJECT

The Monumental Fountain of Dalmine was built to celebrate the 20th anniversary of Benito Mussolini’s historical address held on March 20, 1919, to which the square was dedicated. In the basin stood a large marble block on which some sentences of the Duce’s speech were carved. The work was partially destroyed at the end of the World War II and the block was removed. Today, what remains of the Dalmine Fountain constitutes the privileged meeting place of the city. However, it has great sealing problems as well as high management and maintenance costs, which prevent its normal functioning. Consequently, it is kept empty for many months of the year and filled with water only in the summer. This essay intends to propose a study based on the analysis of historical sources and 3D survey and modelling techniques aimed to understand the historical and urban value of the monument, to support its conservation and to enhance its role as a central meeting point for the town.

Problems of excessive lawmaking in modern Russia

The article is devoted to the problems of a very significant number of federal laws adopted by the State Duma of Russia, especially over the past five years, as well as the weak understanding of legislative acts by officials and ordinary citizens related to these issues, which as a result entails practical non-enforcement of laws. Considering lawmaking as a process necessary for the normal functioning of the state, the author analyses, first of all, quantitative indicators for the annual adoption of federal laws, and he also provides examples from individual regulatory legal acts. As a result of the analysis, as well as taking into account more than twenty years of experience in public authorities, the author identified the causes of excessive lawmaking, conditions conducive to the emergence of a large number of laws. A table showing the number of adopted federal laws for the period from 1994 to 2020 is attached to the article. Based on the results of consideration of the above issues, the author formulated conclusions and suggestions.

Evaluating the COVID-19 impact on surgical practice in Kurdistan Region, Iraq: A cross-sectional study

Background and objective: Surgeons and surgical practice are influenced greatly by the coronavirus disease 2019 (COVID-19) pandemic all over the world, and this impact affects patients who need surgery, especially in emergency cases. This study aimed to assess the impact of COVID-19 on surgery in the Kurdistan Region, Iraq. Methods: A survey that consisted of four sections was prepared and sent by e-mail to over 1000 surgeons with different specialties. The survey was created by google forms and was kept online from 9 October 2020 to 9 November 2020. Results: A total of 207 surgeons have responded to the survey, 146 (70.5%) males and 61 (29.5%) females with different specialists. The data shows that both private and public hospitals were affected by the pandemic equally. Thirty five (16.9%) surgeons indicated that surgery has entirely collapsed in some hospitals. All phases of surgical practice have been affected from partial to complete abandonment of surgery. Conclusion: The pandemic greatly affected surgeons and surgical practice in the Kurdistan region. Additionally, few surgeons indicated that the pandemic did not affect the surgical practice and normal functioning of their hospital. However, most surgeons agreed that the pandemic significantly impels all stages of surgery and surgical practice. Most surgeons have adapted to the situation by using communication technology and new protective measures. Keywords: COVID-19 pandemic; Kurdistan region; Pandemic effects; Surgery; Surgical practice.

Therapeutic enzymes as non-conventional targets in cardiovascular impairments:A Comprehensive Review

Over the last few decades, substantial progress has been made towards the understanding of cardiovascular diseases (CVDs). In-depth mechanistic insights have also provided opportunities to explore novel therapeutic targets and treatment regimens to be discovered. Therapeutic enzymes are an example of such opportunities. The balanced functioning of such enzymes protects against a variety of CVDs while on the other hand, even a small shift in the normal functioning of these enzymes may lead to deleterious outcomes. Owing to the great versatility of these enzymes, inhibition and activation are key regulatory approaches to counter the onset and progression of several cardiovascular impairments. While cardiovascular remedies are already available in excess and of course they are efficacious, a comprehensive description of novel therapeutic enzymes to combat CVDs is the need of the hour. In light of this, the regulation of the functional activity of these enzymes also opens a new avenue for the treatment approaches to be employed. This review describes the importance of non-conventional enzymes as potential candidates in several cardiovascular disorders while highlighting some of the recently targeted therapeutic enzymes in CVDs.