Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial

Edward J Gane; Stuart K Roberts; Catherine AM Stedman; Peter W Angus; Brett Ritchie; Rob Elston; David Ipe; Peter N Morcos; Linda Baher; Isabel Najera; Tom Chu; Uri Lopatin; M Michelle Berrey; William Bradford; Mark Laughlin; Nancy S Shulman; Patrick F Smith

doi:10.1016/s0140-6736(10)61384-0

Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial

The Lancet ◽

10.1016/s0140-6736(10)61384-0 ◽

2010 ◽

Vol 376 (9751) ◽

pp. 1467-1475 ◽

Cited By ~ 250

Author(s):

Edward J Gane ◽

Stuart K Roberts ◽

Catherine AM Stedman ◽

Peter W Angus ◽

Brett Ritchie ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Combination Therapy ◽

Chronic Hepatitis C ◽

Dose Escalation ◽

Genotype 1 ◽

Double Blind ◽

Double Blind Placebo ◽

Polymerase Inhibitor

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Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial

Yearbook of Gastroenterology ◽

10.1016/j.ygas.2011.07.125 ◽

2011 ◽

Vol 2011 ◽

pp. 243-245

Author(s):

D.M. Harnois

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Combination Therapy ◽

Chronic Hepatitis C ◽

Dose Escalation ◽

Genotype 1 ◽

Double Blind ◽

Double Blind Placebo ◽

Polymerase Inhibitor

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Faculty Opinions recommendation of Daclatasvir for previously untreated chronic hepatitis C genotype-1 infection: a randomised, parallel-group, double-blind, placebo-controlled, dose-finding, phase 2a trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717952635.793458150 ◽

2012 ◽

Author(s):

Alex Thompson

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Dose Finding ◽

Genotype 1 ◽

Double Blind ◽

Double Blind Placebo ◽

Parallel Group

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S1942 A Randomized Trial of Standard vs. Dose-Escalation Dosing of Ribavirin in Combination Therapy for Chronic Hepatitis C Patients with Genotype 1 and High Viral Load

Gastroenterology ◽

10.1016/s0016-5085(08)63684-7 ◽

2008 ◽

Vol 134 (4) ◽

pp. A-788-A-789

Author(s):

Yoshiaki Iwasaki ◽

Yasuyuki Araki ◽

Ryo-ichi Okamoto ◽

Hideaki Taniguchi ◽

Yasuhiro Makino ◽

...

Keyword(s):

Chronic Hepatitis ◽

Viral Load ◽

Hepatitis C ◽

Combination Therapy ◽

Randomized Trial ◽

Chronic Hepatitis C ◽

Dose Escalation ◽

High Viral Load ◽

Genotype 1 ◽

Chronic Hepatitis C Patients

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1188 PHASE 2 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF NITAZOXANIDE WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN IN NONRESPONDERS (NR) WITH CHRONIC HEPATITIS C GENOTYPE 1: FINAL REPORT

Journal of Hepatology ◽

10.1016/s0168-8278(10)61189-0 ◽

2010 ◽

Vol 52 ◽

pp. S461 ◽

Cited By ~ 3

Author(s):

M.L. Shiffman ◽

A. Ahmed ◽

I.M. Jacobson ◽

R.E. Pruitt ◽

E.B. Keeffe

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Controlled Study ◽

Final Report ◽

Phase 2 ◽

Genotype 1 ◽

Double Blind ◽

Double Blind Placebo ◽

Peginterferon Alfa

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Randomized, double-blind, placebo-controlled study of peginterferon alfa-2a (40KD) plus ribavirin with or without amantadine in treatment-naïve patients with chronic hepatitis C genotype 1 infection

Journal of Hepatology ◽

10.1016/j.jhep.2005.09.015 ◽

2006 ◽

Vol 44 (2) ◽

pp. 275-282 ◽

Cited By ~ 47

Author(s):

Peter Ferenci ◽

Elisabeth Formann ◽

Hermann Laferl ◽

Michael Gschwantler ◽

Franz Hackl ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Controlled Study ◽

Genotype 1 ◽

Double Blind ◽

Double Blind Placebo ◽

Treatment Naïve ◽

Peginterferon Alfa

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Daclatasvir for previously untreated chronic hepatitis C genotype-1 infection: a randomised, parallel-group, double-blind, placebo-controlled, dose-finding, phase 2a trial

The Lancet Infectious Diseases ◽

10.1016/s1473-3099(12)70138-x ◽

2012 ◽

Vol 12 (9) ◽

pp. 671-677 ◽

Cited By ~ 110

Author(s):

Stanislas Pol ◽

Reem H Ghalib ◽

Vinod K Rustgi ◽

Claudia Martorell ◽

Greg T Everson ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Dose Finding ◽

Genotype 1 ◽

Double Blind ◽

Double Blind Placebo ◽

Parallel Group

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A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Nitazoxanide Plus Peginterferon and Ribavirin in Naïve Patients With Chronic Hepatitis C Genotype 1 Infection: Final Report

Gastroenterology ◽

10.1053/j.gastro.2010.05.067 ◽

2010 ◽

Vol 139 (1) ◽

pp. e18 ◽

Cited By ~ 4

Author(s):

Bruce R. Bacon ◽

Mitchell L. Shiffman ◽

Joseph K. Lim ◽

Arthur Berman ◽

Vinod K. Rustgi ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Phase Ii ◽

Controlled Study ◽

Final Report ◽

Genotype 1 ◽

Double Blind ◽

Double Blind Placebo ◽

Peginterferon And Ribavirin

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Therapeutic vaccination in patients with chronic hepatitis C genotype 1 using four courses of 8 + 6 + 6 + 6 intramuscular injections of 50 µg E1y at 3 week intervals: a multicenter, 3:1 randomized, double-blind, placebo-controlled, parallel-group study over 157 weeks in 122 patients

http://isrctn.org/> ◽

10.1186/isrctn71794661 ◽

2013 ◽

Author(s):

Yves Horsmans

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Therapeutic Vaccination ◽

Genotype 1 ◽

Double Blind ◽

Double Blind Placebo ◽

Parallel Group Study ◽

Intramuscular Injections ◽

Parallel Group

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A randomized double blind, placebo controlled trial of a Chinese herbal preparation (CH100) in chronic Hepatitis C

Gastroenterology ◽

10.1016/s0016-5085(01)81907-7 ◽

2001 ◽

Vol 120 (5) ◽

pp. A384-A384

Author(s):

L MOLLISON ◽

L TOTTEN ◽

C HOVELL ◽

K THAYNE ◽

C CONNELLY ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Controlled Trial ◽

Herbal Preparation ◽

Double Blind ◽

Double Blind Placebo ◽

Chinese Herbal

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324 EFFECT OF VITAMIN D SUPPLEMENT ON T HELPER1/2 CYTOKINE LEVELS IN CHRONIC HEPATITIS C PATIENTS; A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PILOT STUDY

Journal of Hepatology ◽

10.1016/s0168-8278(13)60326-8 ◽

2013 ◽

Vol 58 ◽

pp. S135

Author(s):

K. Charoensuk ◽

C. Chirathaworn ◽

K. Thanapirom ◽

S. Suksawatamnuay ◽

P. Thaimai ◽

...

Keyword(s):

Vitamin D ◽

Chronic Hepatitis ◽

Hepatitis C ◽

Pilot Study ◽

Chronic Hepatitis C ◽

Double Blind ◽

Double Blind Placebo ◽

Cytokine Levels ◽

Chronic Hepatitis C Patients ◽

Vitamin D Supplement

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