scholarly journals Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial

The Lancet ◽  
2016 ◽  
Vol 387 (10037) ◽  
pp. 2507-2520 ◽  
Author(s):  
Robert M Anthenelli ◽  
Neal L Benowitz ◽  
Robert West ◽  
Lisa St Aubin ◽  
Thomas McRae ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Psychiatric Disorders ◽  
Nicotine Patch ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Safety And Efficacy

scholarly journals A Multisite, Double-blind, Placebo-Controlled Clinical Trial to Evaluate the Safety and Efficacy of Vigabatrin for Treating Cocaine Dependence

2013 ◽  
Vol 70 (6) ◽  
pp. 630 ◽  
Author(s):  
Eugene C. Somoza ◽  
Douglas Winship ◽  
Charles W. Gorodetzky ◽  
Daniel Lewis ◽  
Domenic A. Ciraulo ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cocaine Dependence ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Safety And Efficacy ◽  
Double Blind Placebo

scholarly journals Safety and Efficacy of MLC601 in Iranian Patients after Stroke: A Double-Blind, Placebo-Controlled Clinical Trial

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
A. A. Harandi ◽  
R. Abolfazli ◽  
A. Hatemian ◽  
K. Ghragozlee ◽  
M. Ghaffar-Pour ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Ischemic Stroke ◽  
Treatment Group ◽  
Repeated Measures ◽  
Motor Recovery ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Safety And Efficacy ◽  
Stroke Treatment ◽  
Double Blind Placebo

Objective. To investigate the safety and efficacy of MLC601 (NeuroAid) as a traditional Chinese medicine on motor recovery after ischemic stroke.Methods. This study was a double-blind, placebo-controlled clinical trial on 150 patients with a recent (less than 1 month) ischemic stroke. All patients were given either MLC601 (100 patients) or placebo (50 patients), 4 capsules 3 times a day, as an add-on to standard stroke treatment for 3 months.Results. Sex, age, elapsed time from stroke onset, and risk factors in the treatment group were not significantly different from placebo group at baseline (P>.05). Repeated measures analysis showed that Fugl-Meyer assessment was significantly higher in the treatment group during 12 weeks after stroke (P<.001). Good tolerability to treatment was shown, and adverse events were mild and transient.Conclusion. MLC601 showed better motor recovery than placebo and was safe on top of standard ischemic stroke medications especially in the severe and moderate cases.

Safety and efficacy of mucosal immunotherapy using human papillomavirus (HPV) type 16 E7-expressing Lactobacillus-based vaccine for the treatment of high-grade squamous intraepithelial lesion (HSIL): the study protocol of a randomized placebo-controlled clinical trial (MILACLE study)

2019 ◽  
Vol 49 (9) ◽  
pp. 877-880 ◽  
Author(s):  
Yuji Ikeda ◽  
Yukari Uemura ◽  
Mikiko Asai-Sato ◽  
Takehiro Nakao ◽  
Takahiro Nakajima ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Human Papillomavirus ◽  
Phase I ◽  
Study Protocol ◽  
Controlled Clinical Trial ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Double Blind ◽  
Safety And Efficacy ◽  
Intraepithelial Lesion

This is a concept paper of multicenter, placebo-controlled, double-blind randomized phase I/II trial to test the safety and efficacy of IGMKK16E7 for patients with HPV16-positive high-grade squamous intraepithelial lesion.

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