Assessment of the diurnal variation in central corneal thickness and intraocular pressure for patients with suspected glaucoma

BACKGROUND Myopia is a complex trait including both genetic and environmental factors as well as gene-environment interactions. It has been recognized as a risk factor for development of glaucoma. Both Myopia and raised IOP are known to increase mechanical stress at optic nerve head leading to glaucomatous nerve damage. This study intends to evaluate the clinical profile of myopic subjects and its correlation with Primary open angle glaucoma (POAG). METHODS A prospective observational study done from November 2019 to December 2020 after taking proper informed consent and ethical clearance. 164 eyes of 96 patients studied were divided into three groups, Group 1: low myopia (< -3.00D), Group 2: moderate myopia (-3.00 D to -5.75 D), Group 3: high myopia (≥ -6.00 D). A complete ocular examination was performed. Intraocular pressure was measured using Goldmann applanation tonometer. Visual field analysis using Humphrey automated perimetry was done in patients with suspected primary open angle glaucoma (POAG). Angle parameters and central corneal thickness (CCT) were measured using anterior segment optical coherence tomography (AS-OCT). RESULTS 164 eyes of 96 Myopic subjects were studied with no dropout during study period. Mean age was 46.05 yr. (range: 25-75 yr.). The refraction ranged from -0.50 DS to -17.00 DS. There was no statistically significant difference between Intraocular pressure (IOP), Central corneal thickness (CCT), corrected IOP and Nasal and Temporal Trabecular-iris Angle (TIA) between male and female of same age group. Mean IOP and mean CCT were found to vary significantly with age and with higher degree of myopia. Corrected IOP, Nasal and Temporal TIA increase significantly with higher degree of myopia. Cup-disc ratio (CDR) was found to be significantly higher in patients with moderate to high degree of Myopia. CONCLUSIONS Myopia is an important risk factor for development of primary open angle glaucoma, with its incidence increasing in patients with moderate to high myopia. KEYWORDS Myopia, Primary Open Angle Glaucoma, Intraocular Pressure, Central Corneal Thickness, Trabecular Iris Angle

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Pediatric intraocular pressure measurements: Tonometers, central corneal thickness, and anesthesia

Survey of Ophthalmology ◽

10.1016/j.survophthal.2019.05.003 ◽

2019 ◽

Vol 64 (6) ◽

pp. 810-825 ◽

Cited By ~ 2

Author(s):

Mahmoud A. Fayed ◽

Teresa C. Chen

Keyword(s):

Intraocular Pressure ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Pressure Measurements

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Correlation between central corneal thickness and intraocular pressure peak and fluctuation during the water drinking test in glaucoma patients

Clinics ◽

10.1590/s1807-59322010001000007 ◽

2010 ◽

Vol 65 (10) ◽

pp. 967-970 ◽

Cited By ~ 4

Author(s):

Rafael Lacerda Furlanetto ◽

Antonio Carlos Facio Jr ◽

Marcelo Hatanaka ◽

Remo Susanna Junior

Keyword(s):

Intraocular Pressure ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Water Drinking ◽

Pressure Peak ◽

Drinking Test ◽

Water Drinking Test

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Effect of Desonide 0.25% Ophthalmic Solution on Central Corneal Thickness and Intraocular Pressure of Patients with Allergic Conjunctivitis

Asian Journal of Ophthalmology ◽

10.35119/asjoo.v12i3.305 ◽

1970 ◽

Vol 12 (3) ◽

pp. 156-158

Author(s):

Ozlem Gurses Sahin

Keyword(s):

Intraocular Pressure ◽

Allergic Conjunctivitis ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Ophthalmic Solution ◽

Applanation Tonometry ◽

Goldmann Applanation Tonometry ◽

Mean Values ◽

Conjunctival Hyperaemia ◽

Significant Difference

Aim: To evaluate whether a significant difference exists between the initial and final mean central corneal thickness that might affect Goldmann applanation tonometer recordings of patients with allergic conjunctivitis treated with desonide 0.25% ophthalmic solution, and to determine the effect of desonide on intraocular pressure by using adjusted intraocular pressure values.Methods: This double-blind randomised placebo-controlled trial enrolled 30 patients (60 eyes) with allergic conjunctivitis. Patients were randomly assigned to receive desonide to 1 eye (study eye) and preservative-free tear supplement (Tears Naturale Free®) to the other eye (control eye) 3 times daily for 3 weeks. Goldmann applanation tonometry and central corneal thickness of both eyes were recorded on the day of presentation and 3 weeks later.Results: Regression of itching, tearing, conjunctival hyperaemia, and tarsal conjunctival papillary reaction were noted in the study eyes after 3 weeks of treatment. The control eyes showed mild regression of pruritis, tearing, conjunctival hyperaemia, and tarsal conjunctival papillary reaction after 3 weeks. There was a significant difference between the initial and final mean central corneal thickness values for the study eyes (p = 0.003). There were no statistically significant differences between the initial and final mean values of Goldmann applanation tonometry and adjusted intraocular pressure for the study eyes. No statistically significant differences were found between the initial and final mean values of any of the parameters for the control eyes.Conclusion: Inflammation-induced increase in central corneal thickness of patients with allergic conjunctivitis treated with desonide showed statistically significant regression. However, this regression did not significantly affect Goldmann applanation tonometry and adjusted intraocular pressure values of the treated eyes.

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