DNA binding, protein interaction and differential expression of the human germ cell nuclear factor

1999 ◽  
Vol 1446 (3) ◽  
pp. 173-180 ◽  
Author(s):  
Till P. Schmitz ◽  
Ute Süsens ◽  
Uwe Borgmeyer
Keyword(s):  
Dna Binding ◽  
Germ Cell ◽  
Differential Expression ◽  
Protein Interaction ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Nuclear Factor ◽  
Germ Cell Nuclear Factor

Nuclear factor III, a novel sequence-specific DNA-binding protein from HeLa cells stimulating adenovirus DNA replication

Nature ◽  
1986 ◽  
Vol 322 (6080) ◽  
pp. 656-659 ◽  
Author(s):  
Ger J. M. Pruijn ◽  
Wim van Driel ◽  
Peter C. van der Vliet
Keyword(s):  
Dna Replication ◽  
Dna Binding ◽  
Hela Cells ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Nuclear Factor

Evaluation of DNA Binding, Protein Interaction, and Cytotoxic Activity of a Mononuclear Copper(II) Complex

2013 ◽  
Vol 640 (7) ◽  
pp. 1506-1513 ◽  
Author(s):  
Zhanfen Chen ◽  
Jian Zhang ◽  
Pan Zeng ◽  
Shuping Zhang ◽  
Chuanmin Jin
Keyword(s):  
Dna Binding ◽  
Cytotoxic Activity ◽  
Protein Interaction ◽  
Binding Protein ◽  
Dna Binding Protein

scholarly journals Differential expression of single-stranded DNA-binding protein 1 (SSB1) in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Dna Binding ◽  
Differential Expression ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Significant Differential Expression ◽  
Single Stranded Dna ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the nucleic acid binding protein 2, NABP2, also known as SSB1 (single-stranded DNA-binding protein 1) and OBFC2B (oligonucleotide/oligosaccharide-binding fold-containing protein 2B), when comparing primary tumors of the breast to the tissue of origin, the normal breast. SSB1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. SSB1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SSB1 in primary tumors of the breast was correlated with recurrence-free survival in patients with basal subtype cancer. SSB1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

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