OC-0411 The prognostic value of tumor markers in patients with resectable gastric cancer

2021 ◽  
Vol 161 ◽  
pp. S306-S307
Author(s):  
A. Slagter ◽  
M. Vollebergh ◽  
I. Caspers ◽  
J. van Sandick ◽  
K. Sikorska ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Markers ◽  
Prognostic Value ◽  
Resectable Gastric Cancer

scholarly journals Prognostic value of tumor markers and ctDNA in patients with resectable gastric cancer receiving perioperative treatment: results from the CRITICS trial

2021 ◽  
Author(s):  
Astrid E. Slagter ◽  
Marieke A. Vollebergh ◽  
Irene A. Caspers ◽  
Johanna W. van Sandick ◽  
Karolina Sikorska ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Markers ◽  
Prognostic Value ◽  
Cox Regression ◽  
Multivariable Analysis ◽  
Circulating Tumor Dna ◽  
Curative Surgery ◽  
Perioperative Therapy ◽  
Resectable Gastric Cancer ◽  
To Receive

Abstract Aim To evaluate the prognostic value of tumor markers in a European cohort of patients with resectable gastric cancer. Methods We performed a post hoc analysis of the CRITICS trial, in which 788 patients received perioperative therapy. Association between survival and pretreatment CEA, CA 19-9, alkaline phosphatase, neutrophils, hemoglobin and lactate dehydrogenase were explored in uni- and multivariable Cox regression analyses. Likelihoods to receive potentially curative surgery were investigated for patients without elevated tumor markers versus one of the tumor markers elevated versus both tumor markers elevated. The association between tumor markers and the presence of circulating tumor DNA (ctDNA) was explored in 50 patients with available ctDNA data. Results In multivariable analysis, in which we corrected for allocated treatment and other baseline characteristics, elevated pretreatment CEA (HR 1.43; 95% CI 1.11–1.85, p < 0.001) and CA 19-9 (HR 1.79; 95% CI 1.42–2.25, p < 0.001) were associated with worse OS. Likelihoods to receive potentially curative surgery were 86%, 77% and 60% for patients without elevated tumor marker versus either elevated CEA or CA 19-9 versus both elevated, respectively (p < 0.001). Although both preoperative presence of ctDNA and tumor markers were prognostic for survival, no association was found between these two parameters. Conclusion CEA and CA 19-9 were independent prognostic factors for survival in a large cohort of European patients with resectable gastric cancer. No relationship was found between tumor markers and ctDNA. These factors could potentially guide treatment choices and should be included in future trials to determine their definitive position. Trial registration ClinicalTrial.gov identifier: NCT00407186. EudraCT number: 2006-00413032.

scholarly journals The prognostic value of preoperative fibrinogen-to-prealbumin ratio and a novel FFC score in patients with resectable gastric cancer

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Shuli Tang ◽  
Lin Lin ◽  
Jianan Cheng ◽  
Juan Zhao ◽  
Qijia Xuan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Value ◽  
Resectable Gastric Cancer

scholarly journals Prognostic value of perioperative leukocyte count in resectable gastric cancer

2016 ◽  
Vol 22 (9) ◽  
pp. 2818 ◽  
Author(s):  
Xiao-Feng Chen ◽  
Jing Qian ◽  
Dong Pei ◽  
Chen Zhou ◽  
Oluf Dimitri Røe ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Value ◽  
Leukocyte Count ◽  
Resectable Gastric Cancer

Prognostic value of cytosolyc cathepsin D content in resectable gastric cancer

2004 ◽  
Vol 86 (1) ◽  
pp. 16-21 ◽  
Author(s):  
José Manuel del Casar ◽  
Francisco José Vizoso ◽  
Omar Abdel-Laa ◽  
Lourdes Sanz ◽  
Aranzazu Martín ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cathepsin D ◽  
Prognostic Value ◽  
Resectable Gastric Cancer

scholarly journals Prognostic value of preoperative serum lactate dehydrogenase levels for resectable gastric cancer and prognostic nomograms

Oncotarget ◽  
2016 ◽  
Vol 7 (26) ◽  
pp. 39945-39956 ◽  
Author(s):  
Zi-Xian Wang ◽  
Lu-Ping Yang ◽  
Miao-Zhen Qiu ◽  
Zhi-Qiang Wang ◽  
Yi-Xin Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lactate Dehydrogenase ◽  
Prognostic Value ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Preoperative Serum ◽  
Resectable Gastric Cancer

Prognostic Value of Preoperative Clinical Staging Assessed by Computed Tomography in Resectable Gastric Cancer Patients

2010 ◽  
Vol 251 (3) ◽  
pp. 428-435 ◽  
Author(s):  
Sook Ryun Park ◽  
Min Ju Kim ◽  
Keun Won Ryu ◽  
Jun Ho Lee ◽  
Jong Seok Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Computed Tomography ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Clinical Staging ◽  
Resectable Gastric Cancer ◽  
Gastric Cancer Patients

scholarly journals Prognostic Value of the Preoperative Neutrophil to Lymphocyte Ratio in Resectable Gastric Cancer

Medicine ◽  
2015 ◽  
Vol 94 (39) ◽  
pp. e1589 ◽  
Author(s):  
Jun-Te Hsu ◽  
Chun-Kai Liao ◽  
Puo-Hsien Le ◽  
Tsung-Hsing Chen ◽  
Chun-Jung Lin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Value ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Resectable Gastric Cancer
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