21: Response and Toxicity Patterns Seen in Patients Treated with Combination Immunotherapy and Radiotherapy in the Unscarred (Unresectable Squamous Cell Carcinoma Treated with Avelumab and Radical Radiotherapy) Study

2021 ◽  
Vol 163 ◽  
pp. S12
Author(s):  
Deepak Dinakaran ◽  
Naresh Jha ◽  
Kurian Joseph ◽  
John Walker
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Combination Immunotherapy ◽  
Radical Radiotherapy

scholarly journals Single modality radical radiotherapy is an acceptable alternative for the older patient with squamous cell carcinoma of the oesophagus

2021 ◽  
Vol 8 (1) ◽  
pp. e000492
Author(s):  
Sarah Derby ◽  
Matthew Forshaw ◽  
Caroline Lowrie ◽  
Derek Grose ◽  
Husam Marashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cox Regression ◽  
Multimodality Treatment ◽  
Radical Radiotherapy ◽  
Older Patient ◽  
Older Population ◽  
Cox Regression Analysis ◽  
Significant Difference

BackgroundOesophageal cancer remains a common cause of cancer mortality worldwide. Increasingly, oncology centres are treating an older population and comorbidities may preclude multimodality treatment with chemoradiotherapy (CRT). We review outcomes of radical radiotherapy (RT) in an older population treating squamous cell carcinoma (SCC) oesophagus.MethodsPatients over 65 years receiving RT for SCC oesophagus between 2013 and 2016 in the West of Scotland were identified. Kaplan-Meier and Cox-regression analysis were used to compare overall survival (OS) between patients treated with radical RT and radical CRT.ResultsThere were 83 patients over 65 years treated with either RT (n=21) or CRT (n=62). There was no significant difference in median OS between CRT versus RT (26.8 months vs 28.5 months, p=0.92). All patients receiving RT completed their treatment whereas 11% of CRT patients did not complete treatment.ConclusionSurvival in this non-trial older patient group managed with CRT is comparable to that reported in previous trials. RT shows better than expected outcomes which may reflect developments in RT technique. This review supports RT as an alternative in older patients, unfit for concurrent treatment.

scholarly journals Experience of Radical Radiotherapy for Patients with Stages I-III Squamous Cell Carcinoma of the Glottic Larynx

2016 ◽  
Vol 10 (2) ◽  
pp. 63-67
Author(s):  
Md Nizamul Haque ◽  
Sk Golam Mostafa ◽  
Qamruzzaman Chowdhury ◽  
Mokles Uddin ◽  
Syed Akram Hussain ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Treatment Protocol ◽  
Radical Radiotherapy ◽  
Short Term ◽  
Female Ratio ◽  
Grade Ii ◽  
Male To Female ◽  
Conventionally Fractionated

This study was carried out from May 2012 to April 2013, on short term effects of Radical Radiotherapy for patients with Stages I-III squamous cell carcinoma of the glottic larynx at National Institute of Cancer Research and hospital, Mohakhali, Dhaka. A total of 50 biopsy proved squamous cell carcinoma of the glottis larynx were treated with radical Radiotherapy, total dose of which was 66Gy in 33 fractions over 7 weeks, conventionally fractionated with 200 cGy per fraction, one fraction per day and 5 fractions per week, using the machine 6 MV LINAC. The main outcome variables of the study were toxicities and clinical outcome of the patients. The peak age incidence was found in the age group of 51-60 years (56%). Among 50 patients, there were 82% males and 18% females and male to female ratio was 4.6:1. There were 86% found smokers and rests of the 14% patients were non smoker. Treatment related haematological and non-haematological acute and delayed toxicities were studied. Mucosities 28% (grade-II), skin reaction 78% (grade-II), anaemia 52% (grade-II), dysphagia 70% were the most common acute toxicities where as xerostomia 16% was the delayed side effect. With this treatment protocol, 86% patients responded completely.Faridpur Med. Coll. J. Jul 2015;10(2): 63-67

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