Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system

2001 ◽  
Vol 73 (2-3) ◽  
pp. 205-211 ◽  
Author(s):  
B Srividya ◽  
Rita M Cardoza ◽  
P.D Amin
Keyword(s):  
Ophthalmic Delivery ◽  
In Situ Gelling

Study of an alginate/HPMC-based in situ gelling ophthalmic delivery system for gatifloxacin

2006 ◽  
Vol 315 (1-2) ◽  
pp. 12-17 ◽  
Author(s):  
Zhidong Liu ◽  
Jiawei Li ◽  
Shufang Nie ◽  
Hui Liu ◽  
Pingtian Ding ◽  
...  
Keyword(s):  
Delivery System ◽  
Ophthalmic Delivery ◽  
In Situ Gelling

A novel ion-activated in situ gelling ophthalmic delivery system based on κ-carrageenan for acyclovir

2017 ◽  
Vol 44 (5) ◽  
pp. 829-836 ◽  
Author(s):  
Pingfei Li ◽  
Shu Wang ◽  
Haoyuan Chen ◽  
Shiming Zhang ◽  
Shihui Yu ◽  
...  
Keyword(s):  
Delivery System ◽  
Ophthalmic Delivery ◽  
In Situ Gelling

In Situ Gelling of Alginate/Pluronic Solutions for Ophthalmic Delivery of Pilocarpine

2004 ◽  
Vol 5 (6) ◽  
pp. 2358-2365 ◽  
Author(s):  
Hong-Ru Lin ◽  
K. C. Sung ◽  
Wen-Jong Vong
Keyword(s):  
Ophthalmic Delivery ◽  
In Situ Gelling

scholarly journals Development and Optimization of Chitosan-Hydroxypropyl Methylcellulose In Situ Gelling Systems for Ophthalmic Delivery of Bupivacaine Hydrochloride

Processes ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1694
Author(s):  
Lăcrămioara Popa ◽  
Mihaela Violeta Ghica ◽  
Roxana Popescu ◽  
Teodora Irimia ◽  
Cristina-Elena Dinu-Pîrvu
Keyword(s):  
Drug Release ◽  
Hydroxypropyl Methylcellulose ◽  
Second Phase ◽  
Colloidal Systems ◽  
Drug Release Profile ◽  
Bupivacaine Hydrochloride ◽  
Ophthalmic Delivery ◽  
In Situ Gelling

The aim of this study was the development and optimization of chitosan and hydroxypropyl methylcellulose (HPMC) in situ gelling systems, loaded with bupivacaine hydrochloride for topical ocular administration. This study is based on the properties of two polymers: chitosan, which has mucoadhesive action and is a pH-sensitive polymer, but also the cellulose derivative hydroxypropyl methylcellulose, a thermosensitive polymer which has mucoadhesive properties and increases the viscosity of systems. The analysis and optimization of in situ gelling systems were performed based on an experimental design and response surface methodology. The following formulation parameters were considered: X1 = chitosan concentration (0.5%, 1%), X2 = HPMC E 5 LV concentration (2%, 5%) and X3 = Chitosan/HPMC E 5 LV ratio (1/1, 2/1). In addition, the parameters to be optimized were represented by the contact angle (CA (°)), viscosity and cumulative percentage of bupivacaine hydrochloride released in vitro. The results indicate that the designed in situ gelling systems are suitable for bupivacaine prolonged ophthalmic release and overcome the principal disadvantages of the liquid’s ocular formulations. An immediate therapeutic effect corresponding to ocular anesthetic installation was assured in the first stage: burst bupivacaine release. In the second phase, the gradual drug release was assured for over 6 h. This drug release profile, together with the corresponding rheological profile and a collection of superficial properties for good ocular adhesion balanced with an adequate hydrophilic character, assured the desired quality of the attributes for the proposed systems. The system, based on chitosan 1%, HPMC E 5 LV 5% and a 1/1 polymer ratio, could be a solution for the proposed formulation of in situ gelling colloidal systems, since the viscosity of the system was within the range of the optimal viscosity of the eye, and the amount of bupivacaine hydrochloride released after 6 h was the highest at 69.55%.

In vitro and in vivo evaluation of in situ gelling systems for sustained topical ophthalmic delivery: state of the art and beyond

2017 ◽  
Vol 22 (4) ◽  
pp. 638-651 ◽  
Author(s):  
Pierre-Louis Destruel ◽  
Ni Zeng ◽  
Marc Maury ◽  
Nathalie Mignet ◽  
Vincent Boudy
Keyword(s):  
State Of The Art ◽  
In Vivo Evaluation ◽  
Ophthalmic Delivery ◽  
In Situ Gelling
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