Quantitative determination of hepatitis C virus core antigen (HCVAg) and prediction of response to therapy in chronic HCV infection

2002 ◽  
Vol 36 ◽  
pp. 90 ◽  
Author(s):  
Ruth Jacobs ◽  
David Brown ◽  
John Diment ◽  
Josephine Whitehe ◽  
Geoffrey Dusheiko
1994 ◽  
Vol 39 (9) ◽  
pp. 2022-2031 ◽  
Author(s):  
Shinjiro Sato ◽  
Shigetoshi Fujiyama ◽  
Motohiko Tanaka ◽  
Masafumi Goto ◽  
Yuko Taura ◽  
...  

2004 ◽  
Vol 99 (9) ◽  
pp. 1738-1743 ◽  
Author(s):  
Roberta Soffredini ◽  
Maria Grazia Rumi ◽  
Maria Luisa Parravicini ◽  
Guido Ronchi ◽  
Ersilio Del Ninno ◽  
...  

1999 ◽  
Vol 37 (8) ◽  
pp. 2576-2580 ◽  
Author(s):  
Matthias Schröter ◽  
Heinz-Hubert Feucht ◽  
Peter Schäfer ◽  
Bernhard Zöllner ◽  
Rainer Laufs

Serological determination of hepatitis C virus (HCV) subtypes has been hampered by the lack of suitable assays. Therefore, a recombinant immunoblot assay has been established for serological differentiation of HCV subtypes 1a, 1b, 2a, 2b, 3a, and 4a. It consists of recombinant HCV proteins from the NS-4 region propagated in Escherichia coli. To confirm the serotyping assay results, the results were compared with those obtained by nucleotide sequencing of the NS-5 region. Sera from 157 patients with chronic HCV infection were examined by this assay, and specific antibodies could be detected in 86% (n = 135) of them. The HCV genotype was determined correctly in all but one sample, and the subtypes determined by the serotyping assay corresponded to the HCV subtypes detected by nucleotide sequencing for 95% (n = 128) of the samples. These data indicate that HCV subtypes can be distinguished serologically. The assay that is described provides an easier means of identification of infection with different HCV subtypes for wider clinical and epidemiological applications.


2009 ◽  
Vol 6 (1) ◽  
pp. 84 ◽  
Author(s):  
Maarit Sillanpaa ◽  
Krister Melen ◽  
Paivi Porkka ◽  
Riku Fagerlund ◽  
Kaisu Nevalainen ◽  
...  

2018 ◽  
Vol 8 (1) ◽  
pp. 48-54
Author(s):  
Rashed Hassan ◽  
Abdelmonem Elshamy ◽  
Sameh Abdel Monem ◽  
Emad Moustafa ◽  
Essam Wahab

2017 ◽  
Vol 21 (6) ◽  
pp. 1113-1123
Author(s):  
Kazuaki Okino ◽  
Yuki Okushi ◽  
Kiyotaka Mukai ◽  
Yuki Matsui ◽  
Norifumi Hayashi ◽  
...  

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