Metallothionein concentration in the liver of patients with Wilson's disease, primary biliary cirrhosis, and liver metastasis of colorectal cancer

1992 ◽  
Vol 16 (3) ◽  
pp. 346-350 ◽  
Author(s):  
T.P.J. Mulder ◽  
A.R. Janssens ◽  
H.W. Verspaget ◽  
J. van Hattum ◽  
C.B.H.W. Lamers
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Primary Biliary Cirrhosis ◽  
Wilson’S Disease ◽  
Wilson's Disease ◽  
Biliary Cirrhosis

Studies with Radioactive Copper (64Cu and 67Cu); The Incorporation of Radioactive Copper into Caeruloplasmin in Wilson's Disease and in Primary Biliary Cirrhosis

1971 ◽  
Vol 41 (3) ◽  
pp. 189-202 ◽  
Author(s):  
Kathleen Gibbs ◽  
J. M. Walshe
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Control Subject ◽  
Wilson’S Disease ◽  
Wilson's Disease ◽  
Turnover Time ◽  
Control Group ◽  
Biliary Cirrhosis ◽  
Liver Copper ◽  
Secondary Rise ◽  
Copper Overload

1. A comparison has been made of the handling of radioactive copper by patients with Wilson's disease, patients with primary biliary cirrhosis and a small control group. The object of this study has been to assess the influence of an expanded hepatic pool of copper on the incorporation of radioactive copper into caeruloplasmin. 2. Studies with 67Cu have shown that radioactivity disappears steadily from the plasma of patients with Wilson's disease for periods up to 296 h. Both in patients with primary biliary cirrhosis and in controls, a well-marked secondary rise occurs as radioactive copper is incorporated into caeruloplasmin. 3. Caeruloplasmin has been isolated from the serum of one control subject, one patient with primary biliary cirrhosis and one with Wilson's disease. Of the plasma radioactivity 90% was present in the caeruloplasmin of the control subject and the patient with primary biliary cirrhosis; only 27% was found in the caeruloplasmin of the patient with Wilson's disease. 4. Turnover time for liver copper has been determined; in the control subjects it was of the order of 20–30 days, in the patients with primary biliary cirrhosis it was between 600 and 700 days, in Wilson's disease the time exceeded 1800 days. In all cases the turnover time for radioactive copper was significantly less. 5. We conclude (a) that newly arrived radioactive copper is preferentially handled in the presence of copper overload and (b) dilution of radioactive copper in an expanded hepatic pool of the metal cannot alone account for the delayed incorporation found in patients with Wilson's disease.

Incorporation of radiocopper into ceruloplasmin in normal subjects and in patients with primary biliary cirrhosis and Wilson's disease

1978 ◽  
Vol 74 (4) ◽  
pp. 652-660 ◽  
Author(s):  
John M. Vierling ◽  
Richard Shrager ◽  
Warren F. Rumble ◽  
Roger Aamodt ◽  
Marvin D. Berman ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Wilson’S Disease ◽  
Normal Subjects ◽  
Wilson's Disease ◽  
Biliary Cirrhosis

scholarly journals A Patient With Primary Biliary Cirrhosis Accompanied by Wilson’s Disease

2016 ◽  
Vol 16 (2) ◽  
Author(s):  
Su-Xian Zhao ◽  
Yu-Guo Zhang ◽  
Rong-Qi Wang ◽  
Wen-Cong Li ◽  
Ling-Bo Kong ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Wilson’S Disease ◽  
Wilson's Disease ◽  
Biliary Cirrhosis

scholarly journals Unexplained Findings of Kayser-Fleischer-Like Rings in a Patient with Cryptogenic Cirrhosis

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Mahreema Jawairia ◽  
Miral Subhani ◽  
Ghulam Siddiqui ◽  
Apsara Prasad ◽  
Ghulamullah Shahzad ◽  
...  
Keyword(s):  
Liver Disease ◽  
Wilson’S Disease ◽  
The United States ◽  
Wilson's Disease ◽  
Biliary Cirrhosis ◽  
Excessive Alcohol Consumption ◽  
Common Cause ◽  
Nonalcoholic Fatty Liver ◽  
Cryptogenic Cirrhosis ◽  
Alpha 1 Antitrypsin Deficiency

Cryptogenic cirrhosis (CC) is defined as cirrhosis occurring in an individual without an identifiable cause of liver disease, such as excessive alcohol consumption, viral hepatitis infection, hemochromatosis, autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, chronic intake of medications that could induce cirrhosis, alpha-1-antitrypsin deficiency, Wilson’s disease, or any other rare cause of cirrhosis according to the clinical context. Cryptogenic cirrhosis is a common cause of liver-related morbidity and mortality in the United States. Nonalcoholic fatty liver disease is now recognized as the most common cause of cryptogenic cirrhosis. A biopsy specimen is also important for detecting histological advanced disease, which may be clinically silent and undetected by liver-related tests or diagnostic imaging. We are presenting an unusual case of a patient with cryptogenic cirrhosis found to have Kayser-Fleischer-like rings without evidence of Wilson’s disease.

scholarly journals High-performance Photoacoustic Probe for Biopsy-free Assessment of Copper Status in Murine Models of Wilson’s Disease and Liver Metastasis

2021 ◽  
Author(s):  
Melissa Lucero ◽  
Yuqi Tang ◽  
Chloe Zhang ◽  
ShengZhang Su ◽  
Joseph Forzano ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
High Performance ◽  
Wilson’S Disease ◽  
Photoacoustic Imaging ◽  
Disease Model ◽  
Wilson's Disease ◽  
Copper Status ◽  
Metastasis Model ◽  
Healthy Control

<p>The development of high-performance photoacoustic (PA) probes that can monitor disease biomarkers in deep-tissue has the potential to replace invasive medical procedures such as a biopsy. However, such probes must be highly optimized for <i>in vivo</i> performance and exhibit an exceptional safety profile. In this study, we have developed PACu-1, the first PA probe designed for biopsy-free assessment (BFA) of hepatic Cu via photoacoustic imaging. PACu-1 features a Cu(I)-responsive trigger appended to an aza-BODIPY dye platform that has been optimized for ratiometric sensing. Owing to its excellent performance, we were able to detect basal levels of Cu in healthy wildtype mice, as well as elevated Cu in a Wilson’s disease model and in a liver metastasis model. To showcase the potential impact of PACu-1 for BFA, we conducted a blind study where we were able to successfully identify a Wilson’s disease animal from a group of healthy control mice with greater than 99.7% confidence.</p>

scholarly journals High-performance Photoacoustic Probe for Biopsy-free Assessment of Copper Status in Murine Models of Wilson’s Disease and Liver Metastasis

2021 ◽  
Author(s):  
Melissa Lucero ◽  
Yuqi Tang ◽  
Chloe Zhang ◽  
ShengZhang Su ◽  
Joseph Forzano ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
High Performance ◽  
Wilson’S Disease ◽  
Photoacoustic Imaging ◽  
Disease Model ◽  
Wilson's Disease ◽  
Copper Status ◽  
Metastasis Model ◽  
Healthy Control

<p>The development of high-performance photoacoustic (PA) probes that can monitor disease biomarkers in deep-tissue has the potential to replace invasive medical procedures such as a biopsy. However, such probes must be highly optimized for <i>in vivo</i> performance and exhibit an exceptional safety profile. In this study, we have developed PACu-1, the first PA probe designed for biopsy-free assessment (BFA) of hepatic Cu via photoacoustic imaging. PACu-1 features a Cu(I)-responsive trigger appended to an aza-BODIPY dye platform that has been optimized for ratiometric sensing. Owing to its excellent performance, we were able to detect basal levels of Cu in healthy wildtype mice, as well as elevated Cu in a Wilson’s disease model and in a liver metastasis model. To showcase the potential impact of PACu-1 for BFA, we conducted a blind study where we were able to successfully identify a Wilson’s disease animal from a group of healthy control mice with greater than 99.7% confidence.</p>

Activity-based photoacoustic probe for biopsy-free assessment of copper in murine models of Wilson’s disease and liver metastasis

2021 ◽  
Vol 118 (36) ◽  
pp. e2106943118
Author(s):  
Melissa Y. Lucero ◽  
Yuqi Tang ◽  
Chloe J. Zhang ◽  
Shengzhang Su ◽  
Joseph A. Forzano ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
High Performance ◽  
Wilson’S Disease ◽  
Photoacoustic Imaging ◽  
Disease Model ◽  
Wilson's Disease ◽  
Disease Biomarkers ◽  
Metastasis Model ◽  
Healthy Control

The development of high-performance photoacoustic (PA) probes that can monitor disease biomarkers in deep tissue has the potential to replace invasive medical procedures such as a biopsy. However, such probes must be optimized for in vivo performance and exhibit an exceptional safety profile. In this study, we have developed PACu-1, a PA probe designed for biopsy-free assessment (BFA) of hepatic Cu via photoacoustic imaging. PACu-1 features a Cu(I)-responsive trigger appended to an aza-BODIPY dye platform that has been optimized for ratiometric sensing. Owing to its excellent performance, we were able to detect basal levels of Cu in healthy wild-type mice as well as elevated Cu in a Wilson’s disease model and in a liver metastasis model. To showcase the potential impact of PACu-1 for BFA, we conducted two blind studies in which we were able to successfully identify Wilson’s disease animals from healthy control mice in each instance.

Sign in / Sign up

Export Citation Format

Share Document