Should alpha interferon be prescribed at a dose depending on body surface area for the treatment of chronic hepatitis C ?

1994 ◽  
Vol 21 ◽  
pp. S39
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Surface Area ◽  
Body Surface Area ◽  
Chronic Hepatitis C ◽  
Body Surface ◽  
Alpha Interferon

scholarly journals Alpha Interferon Inhibits Hepatitis C Virus Replication in Primary Human Hepatocytes Infected In Vitro

2002 ◽  
Vol 76 (16) ◽  
pp. 8189-8199 ◽  
Author(s):  
Valérie Castet ◽  
Chantal Fournier ◽  
Alexandre Soulier ◽  
Rozenn Brillet ◽  
Joliette Coste ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Primary Cultures ◽  
Indirect Evidence ◽  
Human Hepatocytes ◽  
Alpha Interferon ◽  
Healthy Human

ABSTRACT Chronic hepatitis C is a common cause of liver disease, the complications of which include cirrhosis and hepatocellular carcinoma. Treatment of chronic hepatitis C is based on the use of alpha interferon (IFN-α). Recently, indirect evidence based on mathematical modeling of hepatitis C virus (HCV) dynamics during human IFN-α therapy suggested that the major initial effect of IFN-α is to block HCV virion production or release. Here, we used primary cultures of healthy, uninfected human hepatocytes to show that: (i) healthy human hepatocytes can be infected in vitro and support HCV genome replication, (ii) hepatocyte treatment with IFN-α results in expression of IFN-α-induced genes, and (iii) IFN-α inhibits HCV replication in infected human hepatocytes. These results show that IFN-α acts primarily through its nonspecific antiviral effects and suggest that primary cultures of human hepatocytes may provide a good model to study intrinsic HCV resistance to IFN-α.

scholarly journals Sustained hypothyroidism induced by recombinant alpha interferon in patients with chronic hepatitis C.

Gut ◽  
1992 ◽  
Vol 33 (6) ◽  
pp. 855-856 ◽  
Author(s):  
P Marcellin ◽  
M Pouteau ◽  
P Renard ◽  
J M Grynblat ◽  
N Colas Linhart ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Alpha Interferon

Effect and side-effects of alpha interferon treatment in haemophilia patients with chronic hepatitis C

Haemophilia ◽  
1995 ◽  
Vol 1 (1) ◽  
pp. 45-53 ◽  
Author(s):  
E. P. Mauser-Bunschoten ◽  
D. Bresters ◽  
H. W. Reesink ◽  
G. Roosendaal ◽  
R. A. F. M. Chamuleau ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Side Effects ◽  
Chronic Hepatitis C ◽  
Alpha Interferon ◽  
Interferon Treatment

HLA class II genotypes associated with chronic hepatitis C virus infection and response to alpha-interferon treatment in Poland

2000 ◽  
Vol 20 (3) ◽  
pp. 234-239 ◽  
Author(s):  
Marta Wawrzynowicz-Syczewska ◽  
James A. Underhill ◽  
Michael A. Clare ◽  
Anna Boron-Kaczmarska ◽  
Ian G. McFarlane ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Hla Class Ii ◽  
Alpha Interferon ◽  
Interferon Treatment ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

scholarly journals Acute Hepatitis Induced by Alpha-Interferon in a Patient with Chronic Hepatitis C

2001 ◽  
Vol 15 (5) ◽  
pp. 333-335 ◽  
Author(s):  
Ivan Kraus ◽  
Dinko Vitezic
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Adverse Effects ◽  
Acute Hepatitis ◽  
Chronic Hepatitis C ◽  
Interferon Therapy ◽  
Alpha Interferon ◽  
Aminotransferase Activity ◽  
Immune Mediated ◽  
Very High

Hepatic adverse effects occur very rarely with alpha-interferon therapy. A case of acute hepatitis induced by alpha-interferon in a 33-year-old man with chronic hepatitis C is described. The patient developed acute hepatitis with very high aminotransferase activity and jaundice. After discontinuing alpha-interferon therapy, hepatitis resolved rapidly. The immune-mediated mechanism is the most probable cause of this hepatitis.

Autoimmunity during alpha-interferon therapy for chronic hepatitis C

1993 ◽  
Vol 28 (S5) ◽  
pp. 109-114 ◽  
Author(s):  
M. Yoshikawa ◽  
T. Sakamoto ◽  
A. MitorO ◽  
T. Mochi ◽  
H. Tsujii ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Therapy ◽  
Alpha Interferon
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