1075 DIRECT NON-INVASIVE SERUM MARKERS OF LIVER FIBROSIS PREDICT FIBROSIS EVOLUTION IN CHRONIC HEPATITIS C BUT ARE INCREASED BY INTERFERON-BASED THERAPY

2012 ◽  
Vol 56 ◽  
pp. S423
Author(s):  
S. Tanwar ◽  
P.M. Trembling ◽  
E. Ellis ◽  
J. Parkes ◽  
C. Herold ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Serum Markers ◽  
Non Invasive

Large-scale multicentre comparison of three algorithms combining serum non-invasive markers for liver fibrosis in chronic hepatitis C

2008 ◽  
Vol 40 (10) ◽  
pp. A119-A120
Author(s):  
G. Sebastiani ◽  
P. Halfon ◽  
L. Castera ◽  
A. Mangia ◽  
V. Di Marco ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Large Scale ◽  
Non Invasive

Significance of biglycan and osteopontin as non-invasive markers of liver fibrosis in patients with chronic hepatitis B virus and chronic hepatitis C virus

2018 ◽  
Vol 67 (3) ◽  
pp. 681-685 ◽  
Author(s):  
Ali Sobhy ◽  
Mohammed Fakhry M. ◽  
Haitham A Azeem ◽  
Ahmed M Ashmawy ◽  
Hamed Omar Khalifa
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis B ◽  
Non Invasive ◽  
B Virus

Several studies were performed to evaluate the degree of liver fibrosis by non-invasive markers. We aimed to assess the diagnostic value of both biglycan (BGN) and osteopontin (OPN) as non-invasive markers of hepatic fibrosis in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). This study was performed on 100 patients with CHB virus, 100 patients with CHC virus and 100 normal controls. All participants were subjected to the following laboratory tests: hemoglobin, platelet, alanine aminotransferase, aspartate aminotransferase, albumin, international normalized ratio, HBs Ag, hepatitis C virus (HCV) antibody, hepatitis B virus DNA, HCV RNA, liver biopsy, BGN and OPN. We found that BGN level was significantly increased in the CHB group compared with the controls (p<0.001), but the level was not different between the CHC group and the controls (p<0.96). OPN was increased in both the CHB and CHC groups compared with the controls (p<0.001). Positive correlation was found between fibrosis stages and BGN level of the CHB group (r=0.64; p<0.001) and between fibrosis stages and OPN level of the CHB (r=0.63; p<0.001) and CHC (r=0.59; p<0.03) groups. The area under the curve (AUC), sensitivity and specificity of BGN were 1.0, 100% and 100% in predicting fibrosis in patients with CHB, and 0.50, 26% and 78% in predicting fibrosis in patients with CHC. OPN had an AUC of 0.997, sensitivity of 96% and specificity of 100% in predicting fibrosis in patients with CHB, and 0.974, 96.5% and 100% in predicting fibrosis in patients with CHC. In conclusion, BGN and OPN could be considered non-invasive markers for liver fibrosis assessment.

Novel scores combining AFP with non-invasive markers for prediction of liver fibrosis in chronic hepatitis C patients

2018 ◽  
Vol 90 (6) ◽  
pp. 1080-1086 ◽  
Author(s):  
Mohamed Gamil ◽  
Mohamed Alboraie ◽  
Mohammad El-Sayed ◽  
Aisha Elsharkawy ◽  
Noha Asem ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Non Invasive ◽  
Chronic Hepatitis C Patients

Evolving practices of non-invasive markers of liver fibrosis in patients with chronic hepatitis C in France: Time for new guidelines?

2007 ◽  
Vol 46 (3) ◽  
pp. 528-529 ◽  
Author(s):  
Laurent Castera ◽  
Jacques Denis ◽  
Gerard Babany ◽  
Françoise Roudot-Thoraval
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Non Invasive ◽  
New Guidelines

The predictive value of noninvasive serum markers of liver fibrosis in patients with chronic hepatitis C

2016 ◽  
Vol 27 (2) ◽  
pp. 156-164 ◽  
Author(s):  
Hale Gokcan ◽  
Ufuk Baris Kuzu ◽  
Erkin Oztas ◽  
Fatih Saygili ◽  
Derya Oztuna ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Predictive Value ◽  
Serum Markers

M1575 Are Non-Invasive Biochemical Markers Useful in the Assessment Liver Fibrosis in Patients with Chronic Hepatitis C?

2008 ◽  
Vol 134 (4) ◽  
pp. A-797 ◽  
Author(s):  
José Luis Castro Urda ◽  
Cristina Vicente ◽  
Elvira Quintanilla ◽  
Marta Morán ◽  
David Collado ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Biochemical Markers ◽  
Non Invasive
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