Acute kidney injury in patients with hepatitis B virus related acute-on-chronic liver failure is different from in decompensated cirrhosis

2018 ◽  
Vol 68 ◽  
pp. S243
Author(s):  
Q. Jiang ◽  
M. Han ◽  
K. Ma ◽  
G. Chen ◽  
W. Wu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Failure ◽  
Kidney Injury ◽  
Chronic Liver ◽  
Decompensated Cirrhosis ◽  
Chronic Liver Failure ◽  
B Virus

scholarly journals The Risk of Acute Kidney Injury in Hepatitis B Virus-Related Acute on Chronic Liver Failure with Tenofovir Treatment

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Kai Zhang ◽  
Su Lin ◽  
Mingfang Wang ◽  
Jiaofeng Huang ◽  
Yueyong Zhu
Keyword(s):  
Acute Kidney Injury ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Failure ◽  
Antiviral Drug ◽  
Kidney Injury ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Significant Difference ◽  
B Virus

Aims. Tenofovir (TDF) is an antiviral drug with potential risk of kidney injury. The study is aimed at comparing the incidence of acute kidney injury (AKI) between TDF and entecavir (ETV) treatment in hepatitis B virus- (HBV-) related acute on chronic liver failure (ACLF). Methods. Treatment-naive patients with HBV-related ACLF were included. Propensity score matching was used to balance the baseline characteristics between ETV and TDF groups. The risk of AKI and the efficacy of TDF and ETV were compared. Results. A total of 95 cases with HBV-related ACLF were included in this study, with 74.74% of male and a mean age of 47.01±14.71 years. The antiviral therapy was initiated within 2 days after admission, with 39 cases on the TDF group and 56 on the ETV group. Patients in the TDF group had higher AST, hemoglobin, and serum sodium levels and lower MELD-Na score. After propensity matching, 39 cases of TDF and 39 of ETV were included in the final analysis. No difference was found in the changes of creatinine and cystatin C from baseline to 4 weeks after treatment between ETV and TDF groups. AKI was developed in 1 (2.56%) patient in the ETV group and 2 (5.13%) in the TDF group within one month (P=0.556). Survival analysis revealed no significant difference in the 6-month mortality between the two groups (P=0.813). Cox analysis showed that the type of antiviral drug or the development of AKI was not an independent risk factor for the outcomes. Conclusions. Compared to ETV, TDF did not increase the risk of AKI nor the mortality in patients with HBV-related ACLF in the short time.

HINT: a novel prognostic model for patients with hepatitis B virus-related acute-on-chronic liver failure

2018 ◽  
Vol 48 (7) ◽  
pp. 750-760 ◽  
Author(s):  
Daxian Wu ◽  
Zeyu Sun ◽  
Xiaoli Liu ◽  
Qunfang Rao ◽  
Wenqian Chen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Liver Failure ◽  
Prognostic Model ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
B Virus
Sign in / Sign up

Export Citation Format

Share Document