Relationship between the degree of portal hypertension and liver histologic lesions in patients with alcoholic cirrhosis. Effect of acute alcoholic hepatitis on portal hypertension

Corticosteroid therapy for acute alcoholic hepatitis has been demonstrated to enhance survival in patients who are encephalopathic, and who do not have renal failure or gastrointestinal bleeding. However, the complications of steroid therapy in such patients have been less well documented. The authors report two patients with alcoholic liver disease who developed life-threatening infections after steroid therapy was started. The first patient initially developed diabetes followed by Fournier's gangrene of the perineum, and a lung abscess following septic emboli. The second patient had established alcoholic cirrhosis rather than alcoholic hepatitis. She developed a necrotic ulcer on the arm at the site of an intravenous line, which was infected with a rhizopus species. Despite surgical debridement the lesion progressed and contributed to her death. Treatment of alcoholic hepatitis with steroids is not innocuous, and physicians should be aware of the potential for life-threatening complications.

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Transient hepatofugal portal blood flow in alcoholic cirrhosis with acute alcoholic hepatitis

Journal of Hepatology ◽

10.1016/s0168-8278(05)80075-3 ◽

1994 ◽

Vol 20 (2) ◽

pp. 306-307 ◽

Cited By ~ 2

Author(s):

Thông Dao ◽

Isabelle Lecointe ◽

Marie-Astrid Piquet ◽

Isabelle Jardin-Grimaux ◽

Nicole Bouvard ◽

...

Keyword(s):

Blood Flow ◽

Alcoholic Hepatitis ◽

Alcoholic Cirrhosis ◽

Portal Blood Flow ◽

Portal Blood ◽

Acute Alcoholic Hepatitis

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Serum α-Tocopherol in Patients with Acute Alcoholic Hepatitis, Alcoholic Cirrhosis and Malnutrition

Clinical Science ◽

10.1042/cs079021pb ◽

1990 ◽

Vol 79 (s23) ◽

pp. 21P-21P

Author(s):

G.L.A. Bird ◽

C. Abiaka ◽

RJ Ward ◽

P. Howell ◽

C. Wicks ◽

...

Keyword(s):

Alcoholic Hepatitis ◽

Alcoholic Cirrhosis ◽

Acute Alcoholic Hepatitis

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Comparison of 1-Year Morbidity Following Liver Transplant for Acute Alcoholic Hepatitis Versus Alcoholic Cirrhosis

Experimental and Clinical Transplantation ◽

10.6002/ect.2020.0189 ◽

2021 ◽

Vol 19 (5) ◽

pp. 439-444

Author(s):

Oya Andacoglu ◽

Umut Özbek ◽

Jack Liu ◽

Carlos Figueredo ◽

Kristina R. Chacko ◽

...

Keyword(s):

Liver Transplant ◽

Alcoholic Hepatitis ◽

Alcoholic Cirrhosis ◽

Acute Alcoholic Hepatitis

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Early Liver Transplantation in Acute Alcoholic Hepatitis

Seminars in Liver Disease ◽

10.1055/s-0039-3399560 ◽

2019 ◽

Vol 40 (01) ◽

pp. 029-033

Author(s):

Christine E. Haugen ◽

Andrew M. Cameron

Keyword(s):

United States ◽

Liver Transplantation ◽

Alcoholic Hepatitis ◽

Alcoholic Cirrhosis ◽

The United States ◽

Long Term Outcomes ◽

Acute Alcoholic Hepatitis ◽

Transplant Candidates ◽

Related Liver Disease

AbstractAlcohol-related liver disease (ALD) is currently the leading indication for liver transplantation in the United States. Among patients with ALD, those with acute alcoholic hepatitis who do not respond to medical treatment have a 6-month mortality of 70% without transplantation. Despite the high mortality, the majority of patients will not be eligible for transplant, given that most centers follow the 6-month abstinence rule. A handful of centers in Europe and the United States perform early liver transplantation (< 6 months abstinence) in these patients, as it provides a substantial survival benefit. Short-term outcomes for these recipients are favorable, and relapse rates parallel those seen in alcoholic cirrhosis transplant recipients who have completed the 6-month wait period. Moving forward, studies examining long-term outcomes and candidate selection are necessary for this growing subset of liver transplant candidates.

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