Comparison of tolerance inducibility to class I or class II antigens between cyclophosphamide (CP)-induced tolerance and transfusion with donor cells: General effectiveness of cp-induced tolerance and difference of skin graft prolongation in each class I antigen-disparate combination

Immunobiology ◽  
1992 ◽  
Vol 186 (3-4) ◽  
pp. 282-291 ◽  
Author(s):  
Yukihiro Tomita ◽  
Kikuo Nomoto
1984 ◽  
Vol 159 (3) ◽  
pp. 952-957 ◽  
Author(s):  
A Sher ◽  
D L Sacks ◽  
A J Simpson ◽  
A Singer

Schistosoma mansoni schistosomula recovered from the lungs of mice have previously been shown to express host-derived class I and class II major histocompatibility complex (MHC) antigens. To investigate the tissue origin of parasite-acquired MHC products, lung-stage schistosomula were obtained from a series of parent leads to F1 and F1 leads to parent bone marrow chimeras and the parasites typed by immunofluorescence for the presence of haplotype-specific K region and I region MHC determinants. The results of these experiments indicated that, despite their intravascular residence in the host, schistosomula derive all of their class I antigen from a nonhemapoietic tissue source. In contrast, the class II antigens expressed on the surface of schistosomula were found to originate from bone marrow-derived donor cells. These results support the hypothesis that MHC product acquisition by schistosomes involves selective and specific interactions with host tissue and, in the case of class I antigens, suggest that the endothelium may be a major site of host molecule uptake for the parasite.


1983 ◽  
Vol 59 (2) ◽  
pp. 205-215 ◽  
Author(s):  
Thérèse Neveu ◽  
Michèle Lefroit-Joliy ◽  
Guy André Voisin
Keyword(s):  
Class Ii ◽  
Class I ◽  

1991 ◽  
Vol 106 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Itsuro Higuchi ◽  
Michael Nerenberg ◽  
Toshiharu Ijichi ◽  
Hidetoshi Fukunaga ◽  
Kimiyoshi Arimura ◽  
...  

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