Significant response of oral aphthosis to thalidomide treatment

1985 ◽  
Vol 12 (1) ◽  
pp. 85-90 ◽  
Author(s):  
David Grinspan
Keyword(s):  
Significant Response ◽  
Thalidomide Treatment

Modeling Trienzyme Biosensor at Internal Diffusion Limitation

2004 ◽  
Vol 9 (2) ◽  
pp. 139-144 ◽  
Author(s):  
J. Kulys
Keyword(s):  
Immobilized Enzymes ◽  
Internal Diffusion ◽  
Significant Response ◽  
Diffusion Limitation ◽  
Enzyme Reactions ◽  
Substrate Conversion ◽  
Apparent Stability ◽  
Biosensor Response

A model of biosensor containing three immobilized enzymes utilizing consecutive substrate conversion in the chain was developed. The modeling was performed at an internal diffusion limitation and a steadystate condition. The calculations showed that significant response of biosensors was produced if diffusion modules were larger than 1 for all enzyme reactions. Due to diffusion limitation the apparent stability of biosensor response increased many times in comparison to stability of the most labile enzyme of the chain.

scholarly journals Diagnostic performance of lung volumes in assessment of reversibility in chronic obstructive pulmonary disease

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Gamal Agmy ◽  
Manal A. Mahmoud ◽  
Azza Bahaa El-Din Ali ◽  
Mohamed Adam
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Cutoff Point ◽  
Whole Body ◽  
Significant Response ◽  
Chronic Obstructive ◽  
Lung Volumes ◽  
Obstructive Pulmonary Disease ◽  
Gold Stage ◽  
Clinically Significant

Abstract Background Reversibility measured by spirometry in chronic obstructive pulmonary disease (COPD) is defined as an increase in forced expiratory volume in first second (FEV1) that is both more than 12% and 200 mL above the pre-bronchodilator value in response to inhaled bronchodilators. FEV1 only may not fully reverberate the changes caused by reduction in air trapping or hyperinflation. To date, the studies that examined the effect of inhaled bronchodilators (BD) on residual volume (RV) and total lung capacity (TLC) are limited. This study was carried out to assess the differences between flow and volume responses after bronchodilator reversibility testing in patients with different COPD GOLD stages (GOLD stage I to stage IV). Spirometry and whole body plethysmography were done before and 15 min after inhalation of 400 μg salbutamol. Results Majority (53.3%) of cases were volume responders, 18.7% were flow responders, 20% were flow and volume responders, and 8% were non responders. Significant increase in Δ FEV1% was found in 15% of cases while 55% showed a significant increase in Δ FVC (P= < 0.001). Mean difference of Δ FVC (L) post BD was significantly increased with advancing GOLD stage (P= 0.03). A cutoff point > 20% for Δ RV% had 70% sensitivity and 60% specificity and > 12% for Δ TLC% showed 90% sensitivity and 45% specificity for prediction of clinically significant response to BD based on FEV1. A cutoff point > 18% for Δ RV% had 78% sensitivity and 29% specificity and > 14% for Δ TLC% had 50% sensitivity and 70% specificity for prediction of clinically significant response to BD based on FVC. Conclusion ΔFEV1 underestimates the true effect of bronchodilators with advancing GOLD stage. Measurement of lung volumes in addition to the standard spirometric indices is recommended when determining bronchodilator response in COPD patients.

Thrombomodulin levels are not modified during thalidomide treatment

2006 ◽  
Vol 77 (5) ◽  
pp. 453-454 ◽  
Author(s):  
Patrizia Zappasodi ◽  
Silvia Mangiacavalli ◽  
Virginio Terulla ◽  
Francesca Airò ◽  
Catherine Klersy ◽  
...  
Keyword(s):  
Thalidomide Treatment

Early changes in limb buds of chick embryos after thalidomide treatment

Development ◽  
1966 ◽  
Vol 16 (2) ◽  
pp. 289-300
Author(s):  
A. Jurand
Keyword(s):  
Embryonic Development ◽  
Experimental Investigations ◽  
Experimental Production ◽  
Chick Embryos ◽  
Teratogenic Effects ◽  
Limb Buds ◽  
Experimental Animals ◽  
Almost All ◽  
Thalidomide Treatment

Since the first observations of hypoplastic and aplastic thalidomide deformities in infants (McBride, 1961; Lenz, 1962), the literature on this subject has grown to many hundreds of communications. Experimental investigations in almost all cases have been undertaken to show whether thalidomide and its metabolites have any teratogenic effects in experimental animals. Numerous review papers are available on this subject, e.g. Giroud, Tuchmann-Duplessis & Mercier-Parot (1962), Somers (1963), and Salzgeber & Wolff (1964). Chick embryos did not seem for some time to be suitable for experimental production of typical thalidomide deformities. However, Kemper (1962a, b), Yang, Yang & Liang (1962). Boylen, Home & Johnson (1963) and Leone (1963) have shown that thalidomide can produce a whole range of ectromelian deformities provided that it is introduced into the egg at a particular period of embryonic development.

A unique case of rapidly progressive glomerulonephritis following dexamethasone/bortezomib/thalidomide treatment for myeloma

Nephrology ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 1065-1067
Author(s):  
Ugo Vertolli ◽  
Tamara Berno ◽  
Marcello Riva ◽  
Fausto Adami ◽  
Annalisa Angelini ◽  
...  
Keyword(s):  
Rapidly Progressive Glomerulonephritis ◽  
Unique Case ◽  
Thalidomide Treatment

How Effective is the Standard Dose of Disulfiram? A Review of the Alcohol-Disulfiram Reaction in Practice

1984 ◽  
Vol 144 (2) ◽  
pp. 200-202 ◽  
Author(s):  
Colin Brewer
Keyword(s):  
Side Effects ◽  
Standard Dose ◽  
Recommended Dose ◽  
Significant Response ◽  
Drinking Alcohol ◽  
Current Maximum

SummaryThe current maximum recommended dose of disulfiram, 200 mg daily, is often inadequate. Of 63 patients taking disulfiram under supervision who either risked drinking alcohol or who had a medically supervised challenge with alcohol, only half produced a significant response on a dose of 200–300 mg daily. Some patients need as much as 1.5 g daily but even at high dosage significant side effects are uncommon, reversible and rarely serious.A modification to the recommended technique for a medically supervised alcohol challenge is described, which minimises distress.

Thalidomide: Treatment of choice for aphthous ulcers in patients seropositive for human immunodeficiency virus

1993 ◽  
Vol 28 (2) ◽  
pp. 271-272 ◽  
Author(s):  
Giovanni Ghigliotti ◽  
Tiziana Repetto ◽  
Alessandro Farris ◽  
Maria Teresa Roy ◽  
Roberto De Marchi
Keyword(s):  
Human Immunodeficiency Virus ◽  
Aphthous Ulcers ◽  
Immunodeficiency Virus ◽  
Thalidomide Treatment
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