P2265 Reliability of diagnosing myocardial injury by rapid bedside whole-blood quantitative cardiac troponin-T test in patients with coronary artery disease

Abstract We studied the extent and pattern of increased cardiac troponin T (cTnT) concentrations in 174 hemodialyzed patients. cTnT concentrations were above 0.10 and 0.20 μg/L in 29% and 10% of patients, respectively. In patients without acute coronary disease, the highest value observed was 3.2 μg/L. cTnT increased after dialysis in 10 of 12 patients, with a mean increase of 0.14 μg/L. In 125 patients with samples taken at 1-month intervals, 34% of patients showed differences <20%, but 16% of patients had differences greater than twofold. Serum creatinine and urea, adequacy of dialysis, and duration on dialysis did not explain increased concentrations. Sixty percent of 57 diabetic patients had increased concentrations; the patients with multiple diabetic complications had the highest positivity. cTnT was increased in all eight patients with complications of neuropathy, retinopathy, coronary, and peripheral vascular disease; in 80% of patients with neuropathy; in 77% with peripheral vascular disease; in 73% with retinopathy; and in 70% with coronary artery disease.

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Current Smoking Is Associated With Lower Concentrations of High-Sensitivity Cardiac Troponin T in Patients With Stable Coronary Artery Disease

Circulation ◽

10.1161/circulationaha.119.041991 ◽

2019 ◽

Vol 140 (24) ◽

pp. 2044-2046

Author(s):

Julia B. Skranes ◽

Brian L. Claggett ◽

Peder L. Myhre ◽

Magnus N. Lyngbakken ◽

Scott D. Solomon ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Cardiac Troponin ◽

Troponin T ◽

Stable Coronary Artery Disease ◽

High Sensitivity ◽

Cardiac Troponin T ◽

Current Smoking ◽

Artery Disease

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RISK FACTORS OF CARDIAC TROPONIN T ELEVATION IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE AFTER ELECTIVE CORONARY DRUG-ELUTING STENT IMPLANTATION

Heart ◽

10.1136/heartjnl-2012-302920e.3 ◽

2012 ◽

Vol 98 (Suppl 2) ◽

pp. E150.2-E150

Author(s):

陈章炜 ◽

钱菊英 ◽

马剑英 ◽

葛均波 ◽

葛均波

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Cardiac Troponin ◽

Troponin T ◽

Stable Coronary Artery Disease ◽

Drug Eluting Stent ◽

Cardiac Troponin T ◽

Drug Eluting ◽

Artery Disease

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Effect of Hemodialysis, Coronary Artery Disease and Diabetes on Cardiac Troponin T: A Prospective Survey Over One Year

The Open Cardiovascular Medicine Journal ◽

10.2174/1874192400903010069 ◽

2009 ◽

Vol 3 (1) ◽

pp. 69-77 ◽

Cited By ~ 5

Author(s):

François-Pierre Mongeon ◽

Marc Dorais ◽

Jacques Le Lorier ◽

Daniel Froment ◽

Élaine Letendre ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Cardiac Troponin ◽

Troponin T ◽

Diabetic Patients ◽

Cardiac Troponin T ◽

Coronary Syndrome ◽

Before And After ◽

Artery Disease ◽

Esrd Patients

Background:Limited data is available about the effects of hemodialysis sessions, coronary artery disease (CAD), and diabetes on serum cardiac troponin T (cTnT) levels in patients with end-stage renal disease (ESRD).Objectives:To test whether hemodialysis could be associated with an increase in cTnT concentration. To evaluate if coronary artery disease (CAD) or diabetes are associated with higher cTnT levels in ESRD.Methods:Serum cTnT levels were measured immediately before and after dialysis 3 times over 1 year (0, 6, and 12 months).Results:A total of 100 ESRD patients without acute coronary syndrome (mean age of 58.5 years, 34% with diabetes, and 37% with CAD) gave 267 pre-dialysis and 260 post-dialysis blood samples. The mean (standard deviation) pre-dialysis cTnT levels were 0.06 (0.12), 0.05 (0.06), and 0.07 (0.07) mcg/L at 0, 6, and 12 months, respectively. The post-dialysis cTnT levels were similar on average. Among 259 samples with cTnT measured both before and after dialysis, 79 (30.5%) showed a decrease in serum cTnT, 97 (37.5%) showed an increase and 83 (32%) showed no change following dialysis. Mean cTnT was higher in CAD than in non-CAD patients. We observed no significant difference in mean cTnT levels between diabetic and non-diabetic patients.Conclusions:cTnT levels were not affected by individual hemodialysis sessions, and remained stable around 0.06 mcg/L over a 1-year period in ESRD patients. Random cTnT levels were higher in stable CAD patients undergoing hemodialysis.

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Direct Comparison of Cardiac Troponin T and I Using a Uniform and a Sex-Specific Approach in the Detection of Functionally Relevant Coronary Artery Disease

Clinical Chemistry ◽

10.1373/clinchem.2018.286971 ◽

2018 ◽

Vol 64 (11) ◽

pp. 1596-1606 ◽

Cited By ~ 6

Author(s):

Deborah Mueller ◽

Christian Puelacher ◽

Ursina Honegger ◽

Joan E Walter ◽

Patrick Badertscher ◽

...

Keyword(s):

Computed Tomography ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Diagnostic Accuracy ◽

Cardiac Troponin ◽

Troponin T ◽

High Sensitivity ◽

Emission Computed Tomography ◽

Cardiac Troponin T ◽

Artery Disease

Abstract BACKGROUND We aimed to directly compare high-sensitivity cardiac troponin I (hs-cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) in the detection of functionally relevant coronary artery disease (fCAD). METHODS Consecutive patients referred with clinical suspicion of fCAD and no structural heart disease other than coronary artery disease were included. The presence of fCAD was based on rest/stress myocardial perfusion single-photon emission computed tomography/computed tomography and coronary angiography. hs-cTnI and hs-cTnT concentrations were measured in a blinded fashion. Diagnostic accuracy was quantified using the area under the ROC curve (AUC) and evaluated both for uniform use in all patients and for sex-specific use in women and men separately. The prognostic end point was major adverse cardiac events (MACEs; cardiovascular death or myocardial infarction) within 2 years. For the prognostic performance, we used a multivariable model comparison with the Akaike information criterion (AIC). RESULTS fCAD was detected in 613 of 2062 patients (29.7%) overall, 112 of 664 of women (16.9%), and 501 of 1398 of men (35.8%). hs-cTnI and hs-cTnT had comparable diagnostic accuracy when assessed for uniform use in all patients (AUC, 0.68 vs 0.66; P = 0.107) and separately in women (AUC, 0.68 vs 0.63; P = 0.068) and men (AUC, 0.65 vs 0.64; P = 0.475). However, women required lower rule-out cutoffs to achieve high sensitivity, and men needed higher rule-in cutoffs to achieve high specificity. hs-cTnI and hs-cTnT were strongly and independently associated with MACE within 2 years (P < 0.001), with comparable prognostic accuracies by the AIC. CONCLUSIONS hs-cTnI and hs-cTnT provide moderate and comparable diagnostic accuracy. Sex-specific cutoffs may be preferred. The prognostic utility of both troponins is comparable.

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