Degenerative changes in dog articular cartilage induced by a unilateral tibial valgus osteotomy

1988 ◽  
Vol 33 (3) ◽  
pp. 145-164 ◽  
Author(s):  
R.G. Johnson ◽  
A.R. Poole
1999 ◽  
Vol 367 ◽  
pp. 18???27 ◽  
Author(s):  
Douglas Naudie ◽  
Robert B. Bourne ◽  
Cecil H. Rorabeck ◽  
Timothy J. Bourne

2012 ◽  
Vol 134 (10) ◽  
Author(s):  
M. L. Roemhildt ◽  
B. D. Beynnon ◽  
M. Gardner-Morse ◽  
K. Anderson ◽  
G. J. Badger

This study describes the first application of a varus loading device (VLD) to the rat hind limb to study the role of sustained altered compressive loading and its relationship to the initiation of degenerative changes to the tibio-femoral joint. The VLD applies decreased compressive load to the lateral compartment and increased compressive load to the medial compartment of the tibio-femoral joint in a controlled manner. Mature rats were randomized into one of three groups: unoperated control, 0% (sham), or 80% body weight (BW). Devices were attached to an animal’s leg to deliver altered loads of 0% and 80% BW to the experimental knee for 12 weeks. Compartment-specific material properties of the tibial cartilage and subchondral bone were determined using indentation tests. Articular cartilage, calcified cartilage, and subchondral bone thicknesses, articular cartilage cellularity, and degeneration score were determined histologically. Joint tissues were sensitive to 12 weeks of decreased compressive loading in the lateral compartment with articular cartilage thickness decreased in the peripheral region, subchondral bone thickness increased, and cellularity of the midline region decreased in the 80% BW group as compared to the 0% BW group. The medial compartment revealed trends for diminished cellularity and aggregate modulus with increased loading. The rat-VLD model provides a new system to evaluate altered quantified levels of chronic in vivo loading without disruption of the joint capsule while maintaining full use of the knee. These results reveal a greater sensitivity of tissue parameters to decreased loading versus increased loading of 80% BW for 12 weeks in the rat. This model will allow future mechanistic studies that focus on the initiation and progression of degenerative changes with increased exposure in both magnitude and time to altered compressive loads.


1997 ◽  
Vol 12 (6) ◽  
pp. 635-638 ◽  
Author(s):  
Hans Bergenudd ◽  
Arne Sahlström ◽  
Lennart Sanzén

2021 ◽  
Vol 2130 (1) ◽  
pp. 012009
Author(s):  
R Karpiński ◽  
P Krakowski ◽  
J Jonak ◽  
A Machrowska ◽  
M Maciejewski ◽  
...  

Abstract Osteoarthritis (OA) is currently the most generic form of joint disease. It is a complex process in which degenerative changes occur in the articular cartilage [AC], subchondral bone, and synovial membrane and can lead to permanent joint failure. The primary and most commonly used method of diagnosing degenerative changes is classic radiography. Magnetic resonance imaging (MRI) may be used to assess the extent of damage to joint surfaces, but this method is limited by the availability of specialised equipment and the excessive cost of the examination. Arthroscopy, an invasive procedure, is considered the “gold standard” in joint diagnosis. The occurrence of degenerative changes is closely related to the friction and lubrication processes within the joint. The main causes of osteoarthritis are a change or lack of synovial fluid, deformation of the joint bones, local damage to the articular cartilage, and a change in the mechanical properties of the articular cartilage due to water loss from the damaged superficial layer. An alternative, non-invasive method that allows for a delicate assessment of the condition of moving joints is vibroarthrography (VAG). The analysis of vibroacoustic signals generated by moving joint surfaces has an immense potential in the non-invasive assessment of the degree of damage to articular cartilage, meniscus and ligaments and the general diagnosis of degenerative diseases. The purpose of this study is to analyse and statistically compare the basic characteristics of vibroacoustic signals recorded with a CM-01B contact microphone placed on the patella for motion in the 90°–0°–90° range in a closed kinetic chain (CKC) in a control group (HC) and a group of patients diagnosed with osteoarthritis (OA), qualified for the knee alloplasty.


1997 ◽  
Vol 343 ◽  
pp. 192???202 ◽  
Author(s):  
Harri E. Panula ◽  
Heikki J. Helminen ◽  
Ilkka Kiviranta

2020 ◽  
Vol 5 (4) ◽  
pp. 2473011420S0022
Author(s):  
Brian P. Gallagher ◽  
Walter C. Hembree ◽  
Lew C. Schon

Category: Ankle; Hindfoot Introduction/Purpose: Multiple Lateral column lengthening procedures have been described for the correction of the abduction component of stage II flatfoot deformity. The Hintermann osteotomy, although technically difficult, offers powerful lengthening of the lateral column with low risk of violating the articular cartilage of the subtalar joint as compared to the more widely performed Evans osteotomy. This study reports on the radiographic and clinical outcomes of the Hintermann osteotomy performed by a single surgeon. Methods: Patients who underwent reconstruction for stage II flatfoot deformity with a Hintermann lateral column lengthening were restrospectively identified. The talus-1st metatarsal angle, percent talus uncoverage, calcaneal pitch, lateral column length, CC joint subluxation, and distance from CC joint to the osteotomy were measured on pre and postop radiographs. Radiographic union was also assessed. The Kellgren-Lawrence scale was used to assess degenerative changes at the ST, CC, and TN joints. Charts were reviewed for comorbidities, clinical evidence of union, time to protected weightbearing, time to unrestricted weightbearing, signs of peroneal irritation, clinical signs of osteoarthritis progression, and complications. A paired students t test was used to identify differences in radiographic parameters. Results: Twenty-six patients (30 feet) met inclusion criteria. All osteotomies achieved union with only 1 (1/30) instance of delayed union. Average duration before clinical and radiographic union was 12.6 weeks (9-37). The AP Talus-1st metatarsal angle decreased on average of 12.3 degrees (STD 9.1) (p<0.0001). Percent talus uncoverage decreased on average 17.7 percent (STD 11.5%) (p<0.0001). Subluxation at the CC joint was found to increase on average 1.63mm (STD 1.99) (p<0.01). Only 3 patients (10%) had radiographic progression of osteoarthritis at either the CC or ST joint. No patients showed clinical signs of osteoarthritis and none went on to fusion. One patient had lateral hardware pain necessitating plate removal. Conclusion: The Hintermann osteotomy is a powerful tool for lateral column lengthening. In this series there was significant correction of the preoperative abduction deformity with no nonunions. Degenerative changes in the surrounding hindfoot joints were rare. One benefit of the Hintermann osteotomy is its ability to preserve the articular cartilage of the anterior and middle facets.


Sign in / Sign up

Export Citation Format

Share Document