scholarly journals BACTERIAL ADHERENCE AND HUMORAL IMMUNE RESPONSE IN WOMEN WITH SYMPTOMATIC AND ASYMPTOMATIC URINARY TRACT INFECTION

2006 ◽  
Vol 24 (1) ◽  
pp. 30-33
Author(s):  
S Ethel ◽  
GK Bhat ◽  
BM Hegde
Keyword(s):  
Immune Response ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Humoral Immune Response ◽  
Bacterial Adherence ◽  
Humoral Immune

Bacterial Adherence in Urinary Tract Infection

1987 ◽  
Vol 137 (6) ◽  
Author(s):  
James A. Roberts ◽  
M. Bernice Kaack ◽  
E.N. Fussell
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bacterial Adherence

Innate immune response to bacterial urinary tract infection sensitises high-threshold bladder afferents and recruits silent nociceptors

Pain ◽  
2020 ◽  
Vol 161 (1) ◽  
pp. 202-210
Author(s):  
Stuart M. Brierley ◽  
Kelvin G.K. Goh ◽  
Matthew J. Sullivan ◽  
Kate H. Moore ◽  
Glen C. Ulett ◽  
...  
Keyword(s):  
Immune Response ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Innate Immune Response ◽  
Innate Immune ◽  
High Threshold ◽  
Bladder Afferents

Pathogenesis of urinary tract infection in the elderly: the role of bacterial adherence to uroepithelial cells

1984 ◽  
Vol 11 (2) ◽  
pp. 67-72 ◽  
Author(s):  
Gregor Reid ◽  
Marisa L. Zorzitto ◽  
Andrew W. Bruce ◽  
Michael A. S. Jewett ◽  
Raphael C. Y. Chan ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
The Elderly ◽  
Bacterial Adherence ◽  
Uroepithelial Cells

Bacterial adherence as a virulence factor in urinary tract infection

Apmis ◽  
1990 ◽  
Vol 98 (7-12) ◽  
pp. 1053-1060 ◽  
Author(s):  
PETER Man ◽  
ULF Jodal ◽  
CEES Kooten ◽  
CATHARINA Svanborg
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Virulence Factor ◽  
Bacterial Adherence

scholarly journals Molecular Basis of Uropathogenic Escherichia coli Evasion of the Innate Immune Response in the Bladder

2008 ◽  
Vol 76 (9) ◽  
pp. 3891-3900 ◽  
Author(s):  
Benjamin K. Billips ◽  
Anthony J. Schaeffer ◽  
David J. Klumpp
Keyword(s):  
Escherichia Coli ◽  
Immune Response ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Innate Immune Response ◽  
Molecular Basis ◽  
Neutrophil Recruitment ◽  
Innate Immune ◽  
Cytokine Secretion

ABSTRACT In the urinary tract, the innate immune system detects conserved bacterial components and responds to infection by activating the proinflammatory transcription factor NF-κB, resulting in cytokine secretion and neutrophil recruitment. Uropathogenic Escherichia coli (UPEC), however, has been shown to evade the host innate immune response by suppressing NF-κB activation in urothelial cells, which results in decreased cytokine secretion and increased urothelial apoptosis. To understand the molecular basis of UPEC modulation of inflammation, we performed a genetic screen with UPEC strain NU14 to identify genes which are required for modulation of urothelial cytokine secretion. Disruption of ampG (peptidoglycan permease), waaL (lipopolysaccharide O antigen ligase), or alr (alanine racemase) resulted in increased urothelial interleukin-8 (IL-8) and IL-6 release from urothelial cell cultures. Targeted deletion of these genes also resulted in elevated urothelial cytokine production during UPEC infection. Conditioned media from bacterial cultures of NU14 ΔampG and NU14 ΔwaaL contained a heat-stable factor(s) which stimulated greater urothelial IL-8 secretion than that in NU14-conditioned medium. In a mouse model of urinary tract infection, NU14 ΔampG, NU14 ΔwaaL, and NU14 Δalr were attenuated compared to wild-type NU14 and showed reduced fitness in competition experiments. Instillation of NU14 ΔampG or NU14 ΔwaaL increased bladder neutrophil recruitment, indicating that enhanced urothelial cytokine secretion during urinary tract infection results in an altered host response. Thus, UPEC evasion of innate immune detection of bacterial components, such as lipopolysaccharide and peptidoglycan fragments, is likely an important factor in the ability of UPEC to colonize the urinary tract.

BACTERIAL ADHERENCE AND URINARY TRACT INFECTION

The Lancet ◽  
1982 ◽  
Vol 319 (8278) ◽  
pp. 961-962 ◽  
Author(s):  
P.Helena Mäkelä ◽  
TimoK Korhonen ◽  
Catharina Svanborg Edén ◽  
Lars Hagberg ◽  
LarsA Hanson ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bacterial Adherence
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