Mucosal delivery of the human immunodeficiency virus-1 Tat protein in mice elicits systemic neutralizing antibodies, cytotoxic T lymphocytes and mucosal IgA

Vaccine ◽  
2003 ◽  
Vol 21 (25-26) ◽  
pp. 3972-3981 ◽  
Author(s):  
Mariarosaria Marinaro ◽  
Antonella Riccomi ◽  
Rino Rappuoli ◽  
Mariagrazia Pizza ◽  
Valeria Fiorelli ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Neutralizing Antibodies ◽  
Tat Protein ◽  
Mucosal Delivery ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

Recognition Patterns of HLA-A2–Restricted Human Immunodeficiency Virus-1–Specific Cytotoxic T-Lymphocytes in a Cohort of HIV-1–Infected Individuals

2005 ◽  
Vol 18 (4) ◽  
pp. 627-636 ◽  
Author(s):  
Matthias Schmitt-Haendle ◽  
Oliver Bachmann ◽  
Ellen Harrer ◽  
Barbara Schmidt ◽  
Michael Bäuerle ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Immunodeficiency Virus ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

scholarly journals Human immunodeficiency virus 1. Predominance of a group-specific neutralizing epitope that persists despite genetic variation.

1989 ◽  
Vol 170 (5) ◽  
pp. 1681-1695 ◽  
Author(s):  
I Berkower ◽  
G E Smith ◽  
C Giri ◽  
D Murphy
Keyword(s):  
Genetic Diversity ◽  
Human Immunodeficiency Virus ◽  
Neutralizing Antibodies ◽  
Neutralizing Epitope ◽  
Vaccine Strategy ◽  
Disease Pathogenesis ◽  
Immunodeficiency Virus ◽  
High Degree ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

HIV-1 is known to show a high degree of genetic diversity, which may have major implications for disease pathogenesis and prevention. If every divergent isolate represented a distinct serotype, then effective vaccination might be impossible. However, using a sensitive new plaque-forming assay for HIV-1, we have found that most infected patients make neutralizing antibodies, predominantly to a group-specific epitope shared among three highly divergent isolates. This epitope persists among divergent isolates and rarely mutates, despite the rapid overall mutation rate of HIV-1, suggesting that it may participate in an essential viral function. These findings, plus the rarity of reinfections among these patients, suggest that HIV-1 may be more susceptible to a vaccine strategy based on a group-specific neutralizing epitope than was previously suspected.

Sign in / Sign up

Export Citation Format

Share Document