Metal complexes of the anti-inflammatory drug sodium [2-[(2,6-dichlorophenyl)amino]phenyl]acetate (diclofenac sodium). Molecular and crystal structure of cadmium diclofenac

Polyhedron ◽  
1993 ◽  
Vol 12 (11) ◽  
pp. 1361-1370 ◽  
Author(s):  
Dimitra Kovala-Demertzi ◽  
Dimitris Mentzafos ◽  
Aristidis Terzis
Keyword(s):  
Crystal Structure ◽  
Metal Complexes ◽  
Diclofenac Sodium ◽  
Molecular And Crystal Structure ◽  
Phenyl Acetate ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory Activity of Hydroxytriazenes and their Vanadium Complexes

2008 ◽  
Vol 5 (s2) ◽  
pp. 1144-1148 ◽  
Author(s):  
Kalpana Singh ◽  
Peeyush Patel ◽  
A. K. Goswami
Keyword(s):  
Body Weight ◽  
Metal Complexes ◽  
Diclofenac Sodium ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
Vanadium Complexes ◽  
Standard Drug ◽  
Standard Methods ◽  
Paw Oedema ◽  
Anti Inflammatory

The anti-inflammatory activity of hydroxytriazenes as well as their vanadium complexes has been studied using carrageenan induced hind paw oedema method in albino rats (Wister strain). Hydroxytriazenesviz., 3-hydroxy-1,3-diphenyltriazene(HT-1), 3-hydroxy-3-phenyl-1-(4-sulfonamido)phenyl triazene(HT-2), 3-hydroxy-3-p-chlorophenyl-1-(4-sulfonamido) phenyltriazene(HT-3), 3-hydroxy-3-m-chlorophenyl-1-(4-sulfonamido)phenyltriazene(HT-4)(HT-4) and their respective vanadium complexes C-1, C-2, C-3 and C-4 have been synthesized using standard methods, purified, characterized and used for studying their anti-inflammatory activities. The hind paw oedema was produced by subplanter injection of carrageenan and the paw volume was measured plethysmographically after 0.5, 1, 2, 3 and 5 h. The animals were givenHT-1, HT-2, HT-3andHT-4and also vanadium complexes C-1, C-2, C-3 and C-4 dissolved inDMSO(at dose 5 mg/Kg body weight). Diclofenac sodium (5 mg/kg) was used as a standard drug. The standard drug shows maximum inibition up to 1h as 81.73% which goes on increasing up to 3h (88.94%) but further reduces to 74.93% at the end of 5 h. The test compounds i.e. both ligands as well as their metal complexes show maximum percent inhibition only up to 1h. after which the efficacy reduces. Thus it can be said that both ligands as well as their vanadium complexes show very significant anti-inflammatory activity up to 1h which is comparable to standard drug.

The effects of the nonsteroidal anti-inflammatory drug diclofenac sodium on the rat kidney, and alteration by furosemide

2008 ◽  
Vol 41 (4) ◽  
pp. 919-926 ◽  
Author(s):  
Ayberk Besen ◽  
Fatih Kose ◽  
Saime Paydas ◽  
Gulfiliz Gonlusen ◽  
Tamer Inal ◽  
...  
Keyword(s):  
Rat Kidney ◽  
Diclofenac Sodium ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals Metal Complexes with Mixed Ligands. 6. The Molecular and Crystal Structure of Diimidazole Cobalt(II) Dichloride, Co(C3H4N2)2Cl2.

1972 ◽  
Vol 26 ◽  
pp. 3995-4000 ◽  
Author(s):  
Carl-Johan Antti ◽  
Bruno K. S. Lundberg ◽  
T. Haugen ◽  
Arne Haaland ◽  
Åke Pilotti
Keyword(s):  
Crystal Structure ◽  
Metal Complexes ◽  
Molecular And Crystal Structure ◽  
Mixed Ligands

scholarly journals A Case Report of Multiple Perforations of Transverse Colon Induced by a Non-steroidal Anti-inflammatory Drug (Diclofenac Sodium)

2004 ◽  
Vol 37 (9) ◽  
pp. 1582-1587 ◽  
Author(s):  
Koichiro Sato ◽  
Junji Sagawa ◽  
Ryo Ichinohasama ◽  
Hiroyuki Kumamoto ◽  
Masato Yamaguchi
Keyword(s):  
Case Report ◽  
Transverse Colon ◽  
Diclofenac Sodium ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Potential management of resistant microbial infections with a novel non-antibiotic: the anti-inflammatory drug diclofenac sodium

2007 ◽  
Vol 30 (3) ◽  
pp. 242-249 ◽  
Author(s):  
Noton Kumar Dutta ◽  
Subramanian Annadurai ◽  
Kaushiki Mazumdar ◽  
Sujata G. Dastidar ◽  
Jette E. Kristiansen ◽  
...  
Keyword(s):  
Diclofenac Sodium ◽  
Inflammatory Drug ◽  
Microbial Infections ◽  
Anti Inflammatory
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