A retrospective chart review of risperidone use in treatment-resistant children and adolescents with psychiatric disorders

Author(s):  
Jovan Simeon ◽  
Robert Milin ◽  
Selena Walker
2020 ◽  
Vol 83 (5) ◽  
pp. 1520-1521 ◽  
Author(s):  
Sonal Muzumdar ◽  
Micaella Zubkov ◽  
Reid Waldman ◽  
Madeline E. DeWane ◽  
Rong Wu ◽  
...  

2019 ◽  
Vol 35 (3) ◽  
pp. 242-246 ◽  
Author(s):  
Grant L. Hom ◽  
Sashidaran Moodley ◽  
A. David Rothner ◽  
Manikum Moodley

Background: Segmental neurofibromatosis was initially described by Miller and Sparks (1977) as manifestations of neurofibromatosis limited to a dermatomal, localized distribution. Now termed mosaic neurofibromatosis, previous literature described this disease in children and adolescents with individual case reports and small-numbered case series. This study presents a large series of children and adolescents with mosaic neurofibromatosis. Methods: A retrospective chart review of a single institution medical record database was performed on all cases of mosaic neurofibromatosis diagnosed between the years 1998 and 2017. Eligible subjects were determined by 2 criteria: (1) segmental or unilateral expression of one of more signs of NF I according to those outlined in the NIH criteria and (2) were under 18 years of age at the time of diagnosis. Select information extracted include location of clinical features, NF manifestations (neurofibromas, plexiform neurofibromas, café-au-lait spots, freckling, Lisch nodules), presence of a diffuse area of cutaneous hyperpigmentation, and other significant medical conditions. Results: Sixty-eight cases met established criteria. Average age at diagnosis was 8.28 ± 4.47 years. Thirty-seven (54%) were male and 31 (46%) were female. Localization of the dermatologic manifestations is as follows: left side in 28 (41%) cases, right side in 32 (47%) cases, and bilateral in 8 (11%) cases. Café-au-lait lesions appeared in 64 (94%) of cases and 14 (21%) had axillary and inguinal freckling. Conclusions: This study expands our understanding of the disease characteristics seen in children and adolescents with mosaic neurofibromatosis and confirms the need to focus on pigmentary changes in children with mosaic neurofibromatosis.


2021 ◽  
Author(s):  
Tolesa Fanta ◽  
Kibrom Haile Hagos ◽  
Edao Fejo Hamda ◽  
Eliyas Haile ◽  
Alem Kebede Ejigu ◽  
...  

Abstract Background Studies have suggested that developing good trends in clinical practices in adherence to the recommended processes and guidelines for basic care have been associated with good health outcomes. However, no previous studies have explored trends in psychiatric practices and their impact on relapse among patients with severe mental disorders. Methods: We conducted a retrospective chart review of 401 patients with severe psychiatric disorders selected by systematic random sampling technique. Trends in clinical practice were assessed by a tool adapted from published evidence based on advice from well-known experts in psychiatric practice. A univariable and multivariable logistic regression model was used to investigate the association between psychiatric practices and relapse. Results This study provided evidence of a significant deficit in adherence to the recommended practices of basic care. The vast majority of professionals were not following the appropriate psychiatry history-taking format at first contact (73.6%), not documented the reasons for drug discontinuation (88.5%), did not follow the correct guideline of shifting across psychrotrophic medications (86.8%), and did not put their name or signature on the chart (61.8%). In multivariable analysis, not following psychiatric history taking format at first contact 1.63 (1.04, 2.56)], the diagnosis of bipolar disorders [4.85 (2.01, 8.36)], drug discontinuation after a short duration of treatment [1.21 (1.02, 2.42)], poor documentation of patient data during follow up [3.10 (2.35, 4.43)], absence of name and signature of treating physician on the chart [7.58 (2.64, 21.79)], and failing to treat medication side effect [2.55 (1.02, 6.39)] were found to significant predictors of relapse among the participants. Conclusions The findings provided evidence of notably higher rates of deficits in adherence to the existing guideline of basic psychiatric care, which resulted in a higher risk of relapse among patients with severe psychiatric disorders.


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