Calcium channel blockers in the management of preterm labor and hypertension in pregnancy

2001 ◽  
Vol 97 (2) ◽  
pp. 122-140 ◽  
Author(s):  
Dimitrios N.M. Papatsonis ◽  
Christianne A.R. Lok ◽  
Jacqueline M. Bos ◽  
Herman P.van Geijn ◽  
Gustaaf A. Dekker
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Preterm Labor ◽  
Channel Blockers ◽  
Hypertension In Pregnancy ◽  
In Pregnancy

The Management of Preterm Labor with the Calcium Channel-Blocking Agent Nifedipine Combined with the β-Mimetic Terbutaline

1985 ◽  
Vol 19 (5) ◽  
pp. 369-371 ◽  
Author(s):  
Alan F. Kaul ◽  
Rapin Osathanondh ◽  
Leonard E. Safon ◽  
Fredric D. Frigoletto ◽  
Paul A. Friedman
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Preterm Labor ◽  
Case Reports ◽  
Blocking Agent ◽  
Channel Blockers ◽  
Channel Blocking

We describe a successful, prolonged, inhibition of preterm labor using nifedipine combined with terbutaline in a patient undergoing complicated obstetrical problems. Delivery was delayed for two months and no significant ill effects were observed in the mother or her infant. This case reports the longest duration and the safe use of nifedipine for tocolysis, to date. A review of reports of the use of calcium channel-blockers in preterm labor is also presented.

scholarly journals Are Calcium-Channel Blockers the Most Effective Anti-hypertensive Agent in Black Women With Hypertensive Disorders of Pregnancy? A Systematic Review

2021 ◽  
Author(s):  
Jeeva Reeba John ◽  
Gwenetta Curry
Keyword(s):  
Systematic Review ◽  
Black Women ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Randomised Control Trial ◽  
Channel Blockers ◽  
Hypertensive Disorders ◽  
Black Patients ◽  
Randomised Control Trials ◽  
In Pregnancy

Abstract BackgroundBlack women are four times more likely to die than White women due to complications during pregnancy or childbirth in the U.K. This cohort are also more prone to Hypertensive Disorders in Pregnancy (HDP). Outside of pregnancy, there are race based differences in the management of hypertension as Calcium-Channel Blockers (CCB) are more effective in reducing blood pressure in Black patients. It is unclear whether these differences in anti-hypertensive management extend to the management of hypertension in pregnancy. The primary objective was to address this gap in evidence by undertaking a systematic review of randomised control trials, where one treatment arm comprised of CCBs, investigating pharmacological management of HDP to assess whether CCBs are the most effective anti-hypertensive agent in Black pregnant women.MethodsThe following electronic databases were searched: MEDLINE and Embase. We used MeSH and free text terms in conjunction to increase sensitivity to potentially relevant studies. Inclusion criteria included: (1) study involved drug treatment of HDP; (2) study was of randomised control trial design; (3) one of the treatment arms involved CCBs (4) English full-text and (5) outcome data was stratified by race, and included Black women. Information regarding baseline participant data, type of anti-hypertensive, and clinical outcomes was extracted from each study.ResultsThis review highlighted four randomised control trials, which published race or ethnicity demographics, with only one trial that stratified HDP outcomes by ethnicity. ConclusionsThere is a lack of evidence to draw definite conclusions as to whether CCBs are the most effective anti-hypertensive agent for Black patients with HDP, highlighting the need for further research in this area. However, this review demonstrates some evidence to support the hypothesis that CCBs could be more effective in the management of HDP in Black patients and that Labetalol, which is the current first-line management of HDP, may not represent the gold standard of treatment in this cohort.

scholarly journals Tocolysis among Women with Preterm Birth: Associated Factors and Outcomes from a Multicenter Study in Brazil

2018 ◽  
Vol 40 (04) ◽  
pp. 171-179
Author(s):  
Tabata Dias ◽  
Mariana Fava ◽  
Renato Passini Júnior ◽  
Jose Cecatti ◽  
Ricardo Tedesco ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Preterm Labor ◽  
Expectant Management ◽  
Channel Blockers ◽  
Complication Rates ◽  
Maternal Complications ◽  
Brazilian Sample ◽  
Management Group

Objective To evaluate the use of tocolysis in cases of preterm birth due to spontaneous preterm labor in a Brazilian sample. Methods A sample of 1,491 women with preterm birth due to spontaneous preterm labor were assessed, considering treatment with tocolysis or expectant management, according to gestational age at birth (< 34 weeks and 34 to 36 + 6 weeks) and drugs prescribed. The study took place in 20 Brazilian hospitals from April 2011 to July 2012. Bivariate analyses were conducted to evaluate associations with sociodemographic and obstetric characteristics and odds ratios with their respective 95% confidence intervals were estimated for maternal and neonatal outcomes. Results A total of 1,491 cases of preterm birth were considered. Tocolysis was performed in 342 cases (23%), 233 of which (68.1%) were delivered before 34 weeks. Within the expectant management group, 73% was late preterm and with more advanced labor at the time of admission. The most used drugs were calcium channel blockers (62.3%), followed by betamimetics (33%). Among the subjects in the tocolysis group, there were more neonatal and maternal complications (majority non-severe) and an occurrence of corticosteroid use that was 29 higher than in the expectant management group. Conclusion Tocolysis is favored in cases of earlier labor and also among those with less than 34 weeks of gestation, using preferably calcium channel blockers, with success in achieving increased corticosteroid use. Tocolysis, in general, was related to higher maternal and neonatal complication rates, which may be due to the baseline difference between cases at admission. However, these results should raise awareness to tocolysis use.

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