Safety concerns for the use of calcium channel blockers in pregnancy for the treatment of spontaneous preterm labour and hypertension: a systematic review and meta-regression analysis

2010 ◽  
Vol 23 (9) ◽  
pp. 1030-1038 ◽  
Author(s):  
Khalid Khan ◽  
Javier Zamora ◽  
Ronald F. Lamont ◽  
Herman Van Geijn Hp ◽  
Jens Svare ◽  
...  
Keyword(s):  
Systematic Review ◽  
Regression Analysis ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Preterm Labour ◽  
Channel Blockers ◽  
Safety Concerns ◽  
Meta Regression ◽  
Meta Regression Analysis ◽  
In Pregnancy

scholarly journals Are Calcium-Channel Blockers the Most Effective Anti-hypertensive Agent in Black Women With Hypertensive Disorders of Pregnancy? A Systematic Review

2021 ◽  
Author(s):  
Jeeva Reeba John ◽  
Gwenetta Curry
Keyword(s):  
Systematic Review ◽  
Black Women ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Randomised Control Trial ◽  
Channel Blockers ◽  
Hypertensive Disorders ◽  
Black Patients ◽  
Randomised Control Trials ◽  
In Pregnancy

Abstract BackgroundBlack women are four times more likely to die than White women due to complications during pregnancy or childbirth in the U.K. This cohort are also more prone to Hypertensive Disorders in Pregnancy (HDP). Outside of pregnancy, there are race based differences in the management of hypertension as Calcium-Channel Blockers (CCB) are more effective in reducing blood pressure in Black patients. It is unclear whether these differences in anti-hypertensive management extend to the management of hypertension in pregnancy. The primary objective was to address this gap in evidence by undertaking a systematic review of randomised control trials, where one treatment arm comprised of CCBs, investigating pharmacological management of HDP to assess whether CCBs are the most effective anti-hypertensive agent in Black pregnant women.MethodsThe following electronic databases were searched: MEDLINE and Embase. We used MeSH and free text terms in conjunction to increase sensitivity to potentially relevant studies. Inclusion criteria included: (1) study involved drug treatment of HDP; (2) study was of randomised control trial design; (3) one of the treatment arms involved CCBs (4) English full-text and (5) outcome data was stratified by race, and included Black women. Information regarding baseline participant data, type of anti-hypertensive, and clinical outcomes was extracted from each study.ResultsThis review highlighted four randomised control trials, which published race or ethnicity demographics, with only one trial that stratified HDP outcomes by ethnicity. ConclusionsThere is a lack of evidence to draw definite conclusions as to whether CCBs are the most effective anti-hypertensive agent for Black patients with HDP, highlighting the need for further research in this area. However, this review demonstrates some evidence to support the hypothesis that CCBs could be more effective in the management of HDP in Black patients and that Labetalol, which is the current first-line management of HDP, may not represent the gold standard of treatment in this cohort.

Calcium channel blockers in the management of preterm labor and hypertension in pregnancy

2001 ◽  
Vol 97 (2) ◽  
pp. 122-140 ◽  
Author(s):  
Dimitrios N.M. Papatsonis ◽  
Christianne A.R. Lok ◽  
Jacqueline M. Bos ◽  
Herman P.van Geijn ◽  
Gustaaf A. Dekker
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Preterm Labor ◽  
Channel Blockers ◽  
Hypertension In Pregnancy ◽  
In Pregnancy

scholarly journals Temporal trends in sperm count: a systematic review and meta-regression analysis

2017 ◽  
Vol 23 (6) ◽  
pp. 646-659 ◽  
Author(s):  
Hagai Levine ◽  
Niels Jørgensen ◽  
Anderson Martino-Andrade ◽  
Jaime Mendiola ◽  
Dan Weksler-Derri ◽  
...  
Keyword(s):  
Systematic Review ◽  
Regression Analysis ◽  
Sperm Count ◽  
Temporal Trends ◽  
Meta Regression ◽  
Meta Regression Analysis

scholarly journals Calcium channel blockers and breast cancer incidence: An updated systematic review and meta-analysis of the evidence

2017 ◽  
Vol 50 ◽  
pp. 113-124 ◽  
Author(s):  
Cameron M. Wright ◽  
Rachael E. Moorin ◽  
Enayet K. Chowdhury ◽  
Bruno H. Stricker ◽  
Christopher M. Reid ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Calcium Channel ◽  
Cancer Incidence ◽  
Calcium Channel Blockers ◽  
Meta Analysis ◽  
Breast Cancer Incidence ◽  
Channel Blockers

scholarly journals Long-term manifestations and modifiers of prevalence estimates of the post-COVID-19 syndrome: A systematic review and meta-analysis.

2021 ◽  
Author(s):  
Daniel De-la-Rosa-Martínez ◽  
Marco Antonio Delaye-Martínez ◽  
Omar Yaxmehen Bello-Chavolla ◽  
Alejandro Sicilia-Andrade ◽  
Isaac David Juárez-Cruz ◽  
...  
Keyword(s):  
Systematic Review ◽  
Regression Analysis ◽  
Meta Analysis ◽  
Population Characteristics ◽  
Published Data ◽  
System Disease ◽  
Prevalence Estimates ◽  
Meta Regression ◽  
Meta Regression Analysis

Background: Post-acute COVID-19 syndrome (PACS) is a multi-system disease comprising persistent symptomatology after the acute phase of infection. Long-term PACS effects significantly impact patient outcomes, but their incidence remains uncharacterized due to high heterogeneity between studies. Therefore, we aimed to summarize published data on PACS, characterizing the clinical presentation, prevalence, and modifiers of prevalence estimates. Method: In this systematic review and meta-analysis, we research MEDLINE for original studies published from January 1st, 2020, to January 31st, 2021, that reported proportions of PACS manifestations. Studies were eligible for inclusion if they included patients aged ≥18 years with confirmed COVID-19 by RT-PCR or antigen testing and a minimum follow-up of 21 days. The prevalence of individual manifestations across studies was pooled using random-effects meta-analysis. For evaluating determinants of heterogeneity, meta-regression analysis was performed. This study was registered in PROSPERO (CRD42019125025). Results: After screening 1,235 studies, we included 29 reports for analysis. Twenty-seven meta-analyses were performed, and 61 long-term manifestations were described. The pooled prevalence of PACS was 56% (95%CI 45-66%), with the most common manifestations being diminished health status, fatigue, asthenia, dyspnea, myalgias, hyposmia and dysgeusia. Most of the included studies presented high heterogeneity. After conducting the meta-regression analysis, we identified that age, gender, number of comorbidities, and reported symptoms significantly modify the prevalence estimation of PACS long-term manifestations. Conclusion: PACS is inconsistently reported between studies, and population characteristics influence the prevalence estimates due to high heterogeneity. A systematized approach for the study of PACS is needed to characterize its impact adequately.

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