Calcium Channel Blockers in Pregnancy

1996 ◽  
Vol 1 (5) ◽  
pp. 3-4 ◽  
Author(s):  
L Magee
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
In Pregnancy

Calcium channel blockers in the management of preterm labor and hypertension in pregnancy

2001 ◽  
Vol 97 (2) ◽  
pp. 122-140 ◽  
Author(s):  
Dimitrios N.M. Papatsonis ◽  
Christianne A.R. Lok ◽  
Jacqueline M. Bos ◽  
Herman P.van Geijn ◽  
Gustaaf A. Dekker
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Preterm Labor ◽  
Channel Blockers ◽  
Hypertension In Pregnancy ◽  
In Pregnancy

scholarly journals Are Calcium-Channel Blockers the Most Effective Anti-hypertensive Agent in Black Women With Hypertensive Disorders of Pregnancy? A Systematic Review

2021 ◽  
Author(s):  
Jeeva Reeba John ◽  
Gwenetta Curry
Keyword(s):  
Systematic Review ◽  
Black Women ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Randomised Control Trial ◽  
Channel Blockers ◽  
Hypertensive Disorders ◽  
Black Patients ◽  
Randomised Control Trials ◽  
In Pregnancy

Abstract BackgroundBlack women are four times more likely to die than White women due to complications during pregnancy or childbirth in the U.K. This cohort are also more prone to Hypertensive Disorders in Pregnancy (HDP). Outside of pregnancy, there are race based differences in the management of hypertension as Calcium-Channel Blockers (CCB) are more effective in reducing blood pressure in Black patients. It is unclear whether these differences in anti-hypertensive management extend to the management of hypertension in pregnancy. The primary objective was to address this gap in evidence by undertaking a systematic review of randomised control trials, where one treatment arm comprised of CCBs, investigating pharmacological management of HDP to assess whether CCBs are the most effective anti-hypertensive agent in Black pregnant women.MethodsThe following electronic databases were searched: MEDLINE and Embase. We used MeSH and free text terms in conjunction to increase sensitivity to potentially relevant studies. Inclusion criteria included: (1) study involved drug treatment of HDP; (2) study was of randomised control trial design; (3) one of the treatment arms involved CCBs (4) English full-text and (5) outcome data was stratified by race, and included Black women. Information regarding baseline participant data, type of anti-hypertensive, and clinical outcomes was extracted from each study.ResultsThis review highlighted four randomised control trials, which published race or ethnicity demographics, with only one trial that stratified HDP outcomes by ethnicity. ConclusionsThere is a lack of evidence to draw definite conclusions as to whether CCBs are the most effective anti-hypertensive agent for Black patients with HDP, highlighting the need for further research in this area. However, this review demonstrates some evidence to support the hypothesis that CCBs could be more effective in the management of HDP in Black patients and that Labetalol, which is the current first-line management of HDP, may not represent the gold standard of treatment in this cohort.

Electroanalytical Methods for Determination of Calcium Channel Blockers

2019 ◽  
Vol 15 (3) ◽  
pp. 207-218 ◽  
Author(s):  
Fatma Ağın
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blocker ◽  
Heart Diseases ◽  
Dosage Forms ◽  
Channel Blockers ◽  
Electroanalytical Methods ◽  
Pharmaceutical Dosage Forms ◽  
Ischemic Heart Diseases

Background:Calcium Channel Blockers (CCBs) are widely used in the treatment of cardiovascular and ischemic heart diseases in recent years. They treat arrhythmias by reducing cardiac cycle contraction and also benefit ischemic heart diseases. Electroanalytical methods are very powerful analytical methods used in the pharmaceutical industry because of the determination of therapeutic agents and/or their metabolites in clinical samples at extremely low concentrations (10-50 ng/ml). The purpose of this review is to gather electroanalytical methods used for the determination of calcium channel blocker drugs in pharmaceutical dosage forms and biological media selected mainly from current articles.Methods:This review mainly includes recent determination studies of calcium channel blockers by electroanalytical methods from pharmaceutical dosage forms and biological samples. The studies of calcium channel blockers electroanalytical determination in the literature were reviewed and interpreted.Results:There are a lot of studies on amlodipine and nifedipine, but the number of studies on benidipine, cilnidipine, felodipine, isradipine, lercanidipine, lacidipine, levamlodipine, manidipine, nicardipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, diltiazem, and verapamil are limited in the literature. In these studies, DPV and SWV are the most used methods. The other methods were used less for the determination of calcium channel blocker drugs.Conclusion:Electroanalytical methods especially voltammetric methods supply reproducible and reliable results for the analysis of the analyte. These methods are simple, more sensitive, rapid and inexpensive compared to the usually used spectroscopic and chromatographic methods.

Sign in / Sign up

Export Citation Format

Share Document