Ectopic germinal centres with B and T cells and follicular dendritic cell networks in urethral stricture tissue: Possible avenue for immunological treatments

2021 ◽  
Vol 79 ◽  
pp. S546
Author(s):  
A.T. Olsen Ekerhult ◽  
O. Grimsholm ◽  
J.M Magnusson ◽  
C. Kåbjörn Gustafsson ◽  
R. Peeker
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Urethral Stricture ◽  
Follicular Dendritic Cell ◽  
Germinal Centres ◽  
Follicular Dendritic ◽  
Cell Networks

scholarly journals Regulation of Follicular Dendritic Cell Networks by Activated T Cells: The Role of CD137 Signaling

2005 ◽  
Vol 175 (2) ◽  
pp. 884-890 ◽  
Author(s):  
Yonglian Sun ◽  
Sarah E. Blink ◽  
Jonathan H. Chen ◽  
Yang-Xin Fu
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Follicular Dendritic Cell ◽  
Activated T Cells ◽  
Follicular Dendritic ◽  
Cell Networks

scholarly journals Nodal follicular lymphoma without complete follicular dendritic cell networks is related to localized clinical stage

2011 ◽  
Vol 61 (12) ◽  
pp. 737-741 ◽  
Author(s):  
Wei Cui ◽  
Lisha Che ◽  
Yasuharu Sato ◽  
Xingang Huang ◽  
Katsuyoshi Takata ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Follicular Lymphoma ◽  
Clinical Stage ◽  
Follicular Dendritic Cell ◽  
Follicular Dendritic ◽  
Cell Networks

scholarly journals B Lymphocytes Induce the Formation of Follicular Dendritic Cell Clusters in a Lymphotoxin α–dependent Fashion

1998 ◽  
Vol 187 (7) ◽  
pp. 1009-1018 ◽  
Author(s):  
Yang-Xin Fu ◽  
Guangming Huang ◽  
Yang Wang ◽  
David D. Chaplin
Keyword(s):  
T Cells ◽  
B Cells ◽  
Dendritic Cell ◽  
Follicular Dendritic Cell ◽  
Lymphoid Tissues ◽  
Immune Functions ◽  
Activated T Cells ◽  
Humoral Immune ◽  
Follicular Dendritic

Lymphotoxin (LT)α is expressed by activated T cells, especially CD4+ T helper type 1 cells, and by activated B and natural killer cells, but the functions of this molecule in vivo are incompletely defined. We have previously shown that follicular dendritic cell (FDC) clusters and germinal centers (GCs) are absent from the peripheral lymphoid tissues of LTα-deficient (LTα−/−) mice. LTα−/− mice produce high levels of antigen-specific immunoglobulin (Ig)M, but very low levels of IgG after immunization with sheep red blood cells. We show here that LTα-expressing B cells are essential for the recovery of primary, secondary, and memory humoral immune responses in LTα−/− mice. It is not necessary for T cells to express LTα to support these immune functions. Importantly, LTα-expressing B cells alone are essential and sufficient for the formation of FDC clusters. Once these clusters are formed by LTα-expressing B cells, then LTα-deficient T cells can interact with B cells to generate GCs and productive class-switched antibody responses. Thus, B cells themselves provide an essential signal that induces and maintains the lymphoid microenvironment essential for GC formation and class-switched Ig responses.

scholarly journals Follicular Dendritic Cell-Mediated Up-Regulation of CXCR4 Expression on CD4 T Cells and HIV Pathogenesis

2002 ◽  
Vol 169 (5) ◽  
pp. 2313-2322 ◽  
Author(s):  
Jacob D. Estes ◽  
Brandon F. Keele ◽  
Klara Tenner-Racz ◽  
Paul Racz ◽  
Michael A. Redd ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Cd4 T Cells ◽  
Follicular Dendritic Cell ◽  
Cxcr4 Expression ◽  
Hiv Pathogenesis ◽  
Follicular Dendritic
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