The Identification of Germinal Centres and Follicular Dendritic Cell Networks in Rheumatoid Synovial Tissue

1995 ◽  
Vol 41 (5) ◽  
pp. 481-486 ◽  
Author(s):  
I. RANDEN ◽  
O. J. MELLBYE ◽  
O. FORRE ◽  
J. B. NATVIG
Keyword(s):  
Dendritic Cell ◽  
Synovial Tissue ◽  
Follicular Dendritic Cell ◽  
Germinal Centres ◽  
Rheumatoid Synovial Tissue ◽  
Follicular Dendritic ◽  
Cell Networks

scholarly journals Nodal follicular lymphoma without complete follicular dendritic cell networks is related to localized clinical stage

2011 ◽  
Vol 61 (12) ◽  
pp. 737-741 ◽  
Author(s):  
Wei Cui ◽  
Lisha Che ◽  
Yasuharu Sato ◽  
Xingang Huang ◽  
Katsuyoshi Takata ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Follicular Lymphoma ◽  
Clinical Stage ◽  
Follicular Dendritic Cell ◽  
Follicular Dendritic ◽  
Cell Networks

scholarly journals Regulation of Follicular Dendritic Cell Networks by Activated T Cells: The Role of CD137 Signaling

2005 ◽  
Vol 175 (2) ◽  
pp. 884-890 ◽  
Author(s):  
Yonglian Sun ◽  
Sarah E. Blink ◽  
Jonathan H. Chen ◽  
Yang-Xin Fu
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Follicular Dendritic Cell ◽  
Activated T Cells ◽  
Follicular Dendritic ◽  
Cell Networks

scholarly journals Antiviral B Cell Memory in the Absence of Mature Follicular Dendritic Cell Networks and Classical Germinal Centers in TNFR1−/−Mice

2000 ◽  
Vol 164 (2) ◽  
pp. 768-778 ◽  
Author(s):  
U. Karrer ◽  
C. López-Macías ◽  
A. Oxenius ◽  
B. Odermatt ◽  
M. F. Bachmann ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
B Cell ◽  
Follicular Dendritic Cell ◽  
Germinal Centers ◽  
Cell Memory ◽  
B Cell Memory ◽  
Follicular Dendritic ◽  
Cell Networks

scholarly journals Lymph Node Germinal Centers Form in the Absence of Follicular Dendritic Cell Networks

1999 ◽  
Vol 189 (5) ◽  
pp. 855-864 ◽  
Author(s):  
Pandelakis A. Koni ◽  
Richard A. Flavell
Keyword(s):  
Dendritic Cell ◽  
B Cell ◽  
Follicular Dendritic Cell ◽  
Germinal Centers ◽  
Affinity Maturation ◽  
Antibody Affinity ◽  
B Cell Memory ◽  
Follicular Dendritic ◽  
Cell Networks ◽  
Deficient Mice

Follicular dendritic cell networks are said to be pivotal to both the formation of germinal centers (GCs) and their functions in generating antigen-specific antibody affinity maturation and B cell memory. We report that lymphotoxin β–deficient mice form GC cell clusters in the gross anatomical location expected of GCs, despite the complete absence of follicular dendritic cell networks. Furthermore, antigen-specific GC generation was at first relatively normal, but these GCs then rapidly regressed and GC-phase antibody affinity maturation was reduced. Lymphotoxin β–deficient mice also showed substantial B cell memory in their mesenteric lymph nodes. This memory antibody response was of relatively low affinity for antigen at week 4 after challenge, but by week 10 after challenge was comparable to wild-type, indicating that affinity maturation had failed in the GC phase but developed later.

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