Toosendanin-induced inhibition of small-conductance calcium-activated potassium channels in CA1 pyramidal neurons of rat hippocampus

2001 ◽  
Vol 303 (1) ◽  
pp. 13-16 ◽  
Author(s):  
Zhong-Feng Wang ◽  
Yu-Liang Shi
Keyword(s):  
Potassium Channels ◽  
Pyramidal Neurons ◽  
Rat Hippocampus ◽  
Ca1 Pyramidal Neurons ◽  
Calcium Activated Potassium Channels ◽  
Small Conductance

scholarly journals Dendritic small conductance calcium-activated potassium channels activated by action potentials suppress EPSPs and gate spike-timing dependent synaptic plasticity

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Scott L Jones ◽  
Minh-Son To ◽  
Greg J Stuart
Keyword(s):  
Synaptic Plasticity ◽  
Potassium Channels ◽  
Action Potentials ◽  
Pyramidal Neurons ◽  
Receptor Activation ◽  
Spike Timing ◽  
Sk Channels ◽  
Sk Channel ◽  
Calcium Activated Potassium Channels ◽  
Small Conductance

Small conductance calcium-activated potassium channels (SK channels) are present in spines and can be activated by backpropagating action potentials (APs). This suggests they may play a critical role in spike-timing dependent synaptic plasticity (STDP). Consistent with this idea, EPSPs in both cortical and hippocampal pyramidal neurons were suppressed by preceding APs in an SK-dependent manner. In cortical pyramidal neurons EPSP suppression by preceding APs depended on their precise timing as well as the distance of activated synapses from the soma, was dendritic in origin, and involved SK-dependent suppression of NMDA receptor activation. As a result SK channel activation by backpropagating APs gated STDP induction during low-frequency AP-EPSP pairing, with both LTP and LTD absent under control conditions but present after SK channel block. These findings indicate that activation of SK channels in spines by backpropagating APs plays a key role in regulating both EPSP amplitude and STDP induction.

scholarly journals Down-regulation of the Small Conductance Calcium-activated Potassium Channels in Diabetic Mouse Atria

2015 ◽  
Vol 290 (11) ◽  
pp. 7016-7026 ◽  
Author(s):  
Fu Yi ◽  
Tian-You Ling ◽  
Tong Lu ◽  
Xiao-Li Wang ◽  
Jingchao Li ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Diabetic Mouse ◽  
Down Regulation ◽  
Calcium Activated Potassium Channels ◽  
Small Conductance

Small-conductance calcium-activated potassium channels (SK3) are upregulated following denervation

2013 ◽  
Vol 30 ◽  
pp. 149-149
Author(s):  
C. Kramer ◽  
A. Kretschmer ◽  
C. Ertelt-Delbridge ◽  
M. Blobner ◽  
H. Fink
Keyword(s):  
Potassium Channels ◽  
Calcium Activated Potassium Channels ◽  
Small Conductance
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