In vivo study of motoneuron death induced by nerve injury in mice deficient in the caspase 1/ interleukin-1β-converting enzyme

Neuroscience ◽  
2000 ◽  
Vol 98 (3) ◽  
pp. 573-583 ◽  
Author(s):  
F. de Bilbao ◽  
P. Giannakopoulos ◽  
A. Srinivasan ◽  
M. Dubois-Dauphin
Keyword(s):  
Nerve Injury ◽  
Interleukin 1Β ◽  
In Vivo Study ◽  
Converting Enzyme ◽  
Caspase 1

Novel irreversible caspase-1 inhibitor attenuates the maturation of intracellular interleukin-1β

2007 ◽  
Vol 85 (1) ◽  
pp. 56-65 ◽  
Author(s):  
Xue-Qin Ma ◽  
Hua-Jie Zhang ◽  
Ya-Hui Zhang ◽  
Yi-Hua Chen ◽  
Fang Wu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Proinflammatory Cytokines ◽  
Caspase 3 ◽  
Inflammatory Diseases ◽  
Interleukin 1Β ◽  
Interleukin 18 ◽  
Caspase 1

. Caspase-1, the most efficient enzyme in processing the proinflammatory cytokines interleukin 1β and interleukin 18 in humans, is associated with inflammatory diseases such as rheumatoid arthritis, osteoarthritis, and some neuronal diseases. We previously reported that isoquinoline-1,3,4-trione and its derivatives are novel caspase-3 inhibitors that could attenuate apoptosis in vitro and in vivo. Here we report a novel derivative of isoquinoline-1,3,4-trione that is highly potent in inhibiting caspase-1 activity in an irreversible and slow-binding manner, thus inhibiting cellular caspase-1 activity and the maturation of interleukin 1β in U-937 cells.

Succinic acid amides as P2–P3 replacements for inhibitors of interleukin-1β converting enzyme (ICE or caspase 1)

2010 ◽  
Vol 20 (17) ◽  
pp. 5184-5190 ◽  
Author(s):  
Paul Galatsis ◽  
Bradley Caprathe ◽  
John Gilmore ◽  
Anthony Thomas ◽  
Kristin Linn ◽  
...  
Keyword(s):  
Succinic Acid ◽  
Interleukin 1Β ◽  
Converting Enzyme ◽  
Caspase 1
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