Stereotactic radiosurgery XVI: Isodosimetric comparison of photon stereotactic radiosurgery techniques (gamma knife vs. micromultileaf collimator linear accelerator) for acoustic neuroma—and potential clinical importance

2003 ◽  
Vol 57 (5) ◽  
pp. 1450-1459 ◽  
Author(s):  
Julian Richard Perks ◽  
Edward Jerome St. George ◽  
Karim El Hamri ◽  
Philip Blackburn ◽  
Piers Nicholas Plowman
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Acoustic Neuroma ◽  
Linear Accelerator ◽  
Clinical Importance

scholarly journals Gamma Knife versus Frameless Linear Accelerator Based Stereotactic Radiosurgery for Brain Metastases: Clinical Outcomes and Factors Associated with Local Failure and Radiation Necrosis

2021 ◽  
Author(s):  
Gregory S. Alexander ◽  
Jill S. Remick ◽  
Emily S. Kowalski ◽  
Kai Sun ◽  
Yannick Poirer ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Stereotactic Radiosurgery ◽  
Clinical Outcomes ◽  
Gamma Knife ◽  
Linear Accelerator ◽  
Radiation Necrosis ◽  
Univariate Analysis ◽  
Local Failure ◽  
Rank Test ◽  
Chi Square Analysis

Abstract BackgroundSingle-fraction stereotactic radiosurgery (SF-SRS) for the treatment of brain metastases can be delivered with either a Gamma-Knife platform (GK-SRS) or with a frameless linear accelerator (LA-SRS) which vary based on patterns of prescribing, patient setup and radiation delivery. Whether these differences affect clinical outcomes is unknown. MethodsPatients treated for metastatic brain cancer treated with SF-SRS from 2014-2020 were retrospectively reviewed and clinical outcomes were recorded on a per lesion basis. Covariates between groups were compared using a Chi-square analysis for dichotomous variables and t-test for continuous variables. Median follow up was calculated using the reverse Kaplan Meier (KM) method. Primary endpoints of local failure (LF) and symptomatic radiation necrosis (RN) were estimated using the KM method with salvage WBRT used as a censoring event. Outcome estimates were compared using the log-rank test. Multivariate analysis (MVA) and Cox proportional hazards modeling were used for statistical analyses. Propensity score (PS) adjustments were used to reduce the effects confounding variables.ResultsOverall, 119 patients with 287 lesions were included for analysis which included 57 patients (127 lesions) treated with LA-SRS compared to 62 patients (160 lesions) treated with GK-SRS. On both multivariate and univariate analysis, there was no statistically significant differences between GK-SRS and LA-SRS for LF, RN, or the combined endpoint of either LF or RN (multivariate p-value=0.17).ConclusionsIn our retrospective cohort, we found no statistically significant differences in the incidence of RN or LF in patients treated with GK-SRS when compared to LA-SRS.Trial Registration: Retrospectively registered

Malignant Transformation of Acoustic Neuroma 10 Years after Gamma-Knife Stereotactic Radiosurgery

Skull Base ◽  
2009 ◽  
Vol 19 (01) ◽  
Author(s):  
Andreas Demetriades ◽  
Nicholas Saunders ◽  
Peter Rose ◽  
Cyril Fisher ◽  
Robert Tranter ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Malignant Transformation ◽  
Gamma Knife ◽  
Acoustic Neuroma ◽  
Gamma Knife Stereotactic Radiosurgery

Safety and Efficacy of Tiered Limited-Dose Gamma Knife Stereotactic Radiosurgery for Unilateral Acoustic Neuroma

2004 ◽  
Vol 82 (4) ◽  
pp. 147-152 ◽  
Author(s):  
Howard J. Landy ◽  
Arnold M. Markoe ◽  
Xiaodong Wu ◽  
Sherri J. Patchen ◽  
Isildinha M. Reis ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Acoustic Neuroma ◽  
Safety And Efficacy ◽  
Gamma Knife Stereotactic Radiosurgery

scholarly journals Radiomic assessment of the progression of acoustic neuroma after gamma knife stereotactic radiosurgery

2019 ◽  
Vol 9 (2) ◽  
pp. 1
Author(s):  
Ganesh Narayanasamy ◽  
Geoffrey Zhang ◽  
Eric Siegel ◽  
Graham Campbell ◽  
Eduardo G. Moros ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Acoustic Neuroma ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Hearing Preservation ◽  
Magnetic Resonance Images ◽  
Acoustic Neuromas ◽  
Gray Tone ◽  
Gamma Knife Stereotactic Radiosurgery

Introduction: The aim of this study was to determine whether radiomic features measured at baseline in Magnetic Resonance images (MRI) of acoustic neuromas (AN) can predict Gamma Knife (GK) treatment outcome.Methods: The study was conducted on pre- and post-GK MRI-T2 scans of 32 patients with AN who underwent stereotactic radiosurgery (SRS) for 12 Gy dose. Radiomic features extracted include Intensity, Fractals, Laplacian of Gaussian and textural Co-Occurrence, Run-length (RL), Size Zone, and Neighborhood Gray-Tone Difference matrices (NGTDM) features. Subjects were classified as treatment failures (TF) if tumor volume increased > 10%. Pre- and post-SRS audiology reports were utilized in hearing evaluation.Results: Fifteen subjects (47%) qualified as TFs. In univariate receiver operating characteristic (ROC) analysis, two radiomicfeatures, complexity in NGTDM and run percentage in RL, displayed areas under curves of > 0.65.Conclusion: This initial radiomic study establishes features that illustrates the prognostic ability of the SRS treatment in acousticneuroma. Hearing preservation was achieved in a majority of acoustic neuroma patients treated in Gamma Knife.

scholarly journals Radiomic assessment of the progression of acoustic neuroma after gamma knife stereotactic radiosurgery

2019 ◽  
Vol 9 (2) ◽  
pp. 1
Author(s):  
Ganesh Narayanasamy ◽  
Geoffrey Zhang ◽  
Eric Siegel ◽  
Graham Campbell ◽  
Eduardo G. Moros ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Acoustic Neuroma ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Hearing Preservation ◽  
Magnetic Resonance Images ◽  
Acoustic Neuromas ◽  
Gray Tone ◽  
Gamma Knife Stereotactic Radiosurgery

Introduction: The aim of this study was to determine whether radiomic features measured at baseline in Magnetic Resonance images (MRI) of acoustic neuromas (AN) can predict Gamma Knife (GK) treatment outcome.Methods: The study was conducted on pre- and post-GK MRI-T2 scans of 32 patients with AN who underwent stereotactic radiosurgery (SRS) for 12 Gy dose. Radiomic features extracted include Intensity, Fractals, Laplacian of Gaussian and textural Co-Occurrence, Run-length (RL), Size Zone, and Neighborhood Gray-Tone Difference matrices (NGTDM) features. Subjects were classified as treatment failures (TF) if tumor volume increased > 10%. Pre- and post-SRS audiology reports were utilized in hearing evaluation.Results: Fifteen subjects (47%) qualified as TFs. In univariate receiver operating characteristic (ROC) analysis, two radiomicfeatures, complexity in NGTDM and run percentage in RL, displayed areas under curves of > 0.65.Conclusion: This initial radiomic study establishes features that illustrates the prognostic ability of the SRS treatment in acousticneuroma. Hearing preservation was achieved in a majority of acoustic neuroma patients treated in Gamma Knife.

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