Predictive value of dose-volume histogram parameters for pericardial effusion after concurrent chemoradiotherapy for esophageal cancer

2004 ◽  
Vol 60 ◽  
pp. S420-S420
Author(s):  
Y ITO ◽  
S ISHIKURA ◽  
S HIROTA ◽  
T SOEJIMA ◽  
K TSUJINO ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Pericardial Effusion ◽  
Predictive Value ◽  
Concurrent Chemoradiotherapy ◽  
Dose Volume Histogram ◽  
Dose Volume

Analysis of dose–volume histogram parameters for radiation pneumonitis after definitive concurrent chemoradiotherapy for esophageal cancer

2010 ◽  
Vol 95 (2) ◽  
pp. 240-244 ◽  
Author(s):  
Hirofumi Asakura ◽  
Takayuki Hashimoto ◽  
Sadamoto Zenda ◽  
Hideyuki Harada ◽  
Koichi Hirakawa ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Concurrent Chemoradiotherapy ◽  
Radiation Pneumonitis ◽  
Dose Volume Histogram ◽  
Dose Volume

scholarly journals Analysis of cardiac toxicity after definitive chemoradiotherapy for esophageal cancer using a biological dose–volume histogram

2020 ◽  
Vol 61 (2) ◽  
pp. 298-306
Author(s):  
Yuki Takeuchi ◽  
Yuji Murakami ◽  
Tsubasa Kameoka ◽  
Masanori Ochi ◽  
Nobuki Imano ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Cardiac Toxicity ◽  
Dose Volume Histogram ◽  
Definitive Chemoradiotherapy ◽  
Heart Dose ◽  
Dose Volume ◽  
The Mean ◽  
Mean Heart Dose ◽  
The Relationship

Abstract This study aimed to evaluate the relationship between cardiac toxicity after definitive chemoradiotherapy (CRT) for esophageal cancer and the dose–volume histogram (DVH) of organs at risk (OARs) [using biological effective dose (BED)]. We analyzed the data of 83 patients with esophageal cancer treated using definitive CRT between 2001 and 2016. Furthermore, we evaluated pericardial effusion (PE) as a measure of cardiac toxicity. The median total irradiation dose was 60 (50.4–71) Gy. Symptomatic PE was observed in 12 (14%) patients. The heart and pericardium V5–V100-BED were significantly higher in patients with symptomatic PE than in those without symptomatic PE (heart: V5–V95-BED, P < 0.001; V100-BED, P = 0.0053, and pericardium: V5–V40-BED, V55–V95-BED, P < 0.001; V45–50-BED, V100-BED, P < 0.05, respectively). Receiver operating characteristic curve analysis showed that the dose–volume parameter of the pericardium and the heart that was most strongly associated with an adverse cardiac event was V80-BED, and the mean dose and the cut-off value were 27.38% and 61.7 Gy-BED, respectively. Multivariate analysis showed that the pericardium V80-BED and the mean heart dose-BED were risk factors for symptomatic PE (P < 0.001, respectively). We revealed the relationship between the irradiated dose of the OARs and symptomatic PE using a BED-based dose–volume histogram. Pericardium V80-BED and mean heart dose-BED were the most relevant risk factors for symptomatic PE.

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