2047 The influence of young age and positive family history on local recurrence after three treatment strategies for ductal carcinoma in situ

1997 ◽  
Vol 39 (2) ◽  
pp. 264
Author(s):  
Kathleen A. Szelei-Stevens ◽  
Robert R. Kuske ◽  
John S. Bolton ◽  
John C. Bowen ◽  
George M. Fuhrman ◽  
...  
Keyword(s):  
Family History ◽  
Local Recurrence ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Positive Family History ◽  
Treatment Strategies ◽  
Young Age

scholarly journals The Selection of Treatment Modality for Breast Ductal Carcinoma In Situ: Experience From a Single Institution

2021 ◽  
Vol 28 ◽  
pp. 107327482199742
Author(s):  
Kai-yun You ◽  
Zhuo-fei Bi ◽  
Yu-jia Ma ◽  
Yong-lin Mao ◽  
Wei-liang Zou ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Ductal Carcinoma In Situ ◽  
Adjuvant Radiotherapy ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Multivariable Analysis ◽  
Tumor Grade ◽  
Treatment Method ◽  
Free Survival

Purpose: Although breast conservation surgery(BCS) followed by adjuvant radiotherapy is now the mainstream treatment method for breast ductal carcinoma in situ(DCIS), mastectomy is still performed in some patients who refuse to undergo radiation. However, the most effective treatment method for these patients is still unknown. In the current study, we aimed to compare the survival rates between mastectomy and BCS plus adjuvant radiotherapy in patients with DCIS. Materials and Methods: We performed a retrospective study of 333 patients with DCIS from May 2004 to December 2016. There were 209 patents who were treated with BCS and adjuvant radiotherapy, while the remaining of 124 patients underwent mastectomy. The disease-free survival (DFS) and local recurrence-free survival(LRFS) rates were compared between the 2 treatment groups. Cox proportional hazards regression was performed to explore factors associated with DFS and LRFS. Results: The 10-year local recurrence(LR) rates in the mastectomy and BCS plus adjuvant radiotherapy groups were 2.6% and 7.5%, respectively. There was no difference in the LR rate between the 2 groups. Furthermore the DFS rate was also similar between the mastectomy and BCS plus adjuvant radiotherapy groups. Based on the multivariable analysis, age and tumor grade were significantly correlated with the LRFS and DFS rates. In the subgroup analysis based on the factors of age and tumor grade, patients with a tumor grade of III who underwent mastectomy had better LRFS and DFS rates compared to those who received BCS plus radiotherapy. Conclusion: In patients with DCIS, the long-term efficacy was similar between mastectomy and BCS followed by adjuvant radiotherapy. However, in the subgroup of patients with grade III tumors, mastectomy seems to offer a better LRFS and DFS than BCS plus radiotherapy.

Local Recurrence After Mastectomy for Ductal Carcinoma In Situ

1998 ◽  
Vol 4 (6) ◽  
pp. 430-436 ◽  
Author(s):  
Richard C. Montgomery ◽  
Barbara L. Fowble ◽  
Lori J. Goldstein ◽  
David P. May ◽  
John P. Hoffman ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma

scholarly journals A Quantitative Centrosomal Amplification Score Predicts Local Recurrence of Ductal Carcinoma In Situ

2020 ◽  
Vol 26 (12) ◽  
pp. 2898-2907 ◽  
Author(s):  
Karuna Mittal ◽  
Michael S. Toss ◽  
Guanhao Wei ◽  
Jaspreet Kaur ◽  
Da Hoon Choi ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma
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