Influence of patient positioning on dose-volume histogram and normal tissue complication probability for small bowel and bladder in patients receiving pelvic irradiation:

1999 ◽  
Vol 45 (5) ◽  
pp. 1193-1198 ◽  
Author(s):  
Oliver Koelbl ◽  
Susanne Richter ◽  
Michael Flentje
Keyword(s):  
Small Bowel ◽  
Normal Tissue ◽  
Patient Positioning ◽  
Normal Tissue Complication Probability ◽  
Dose Volume Histogram ◽  
Pelvic Irradiation ◽  
Dose Volume

scholarly journals The Different Dose-Volume Effects of Normal Tissue Complication Probability Using LASSO for Acute Small-Bowel Toxicity during Radiotherapy in Gynecological Patients with or without Prior Abdominal Surgery

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Tsair-Fwu Lee ◽  
Eng-Yen Huang
Keyword(s):  
Small Bowel ◽  
Abdominal Surgery ◽  
Acute Diarrhea ◽  
Normal Tissue ◽  
Normal Tissue Complication Probability ◽  
Surgery Group ◽  
Dose Volume ◽  
Prescription Dose ◽  
Group 1 ◽  
Volume Effects

Purpose. To develop normal tissue complication probability (NTCP) model with least absolute shrinkage and selection operator (LASSO) to analyze dose-volume effects that influence the incidence of acute diarrhea among gynecological patients with/without prior abdominal surgery.Methods and Materials. Ninety-five patients receiving gynecologic radiotherapy (RT) were enrolled. The endpoint was defined as the grade 2+acute diarrhea toxicity during treatment. We obtained the range of small-bowel volume in V4 Gy to V40 Gy of dose.Results. The number of patients experiencing grade 2+acute diarrhea toxicity was 23/61 (38%) in the group without abdominal surgery (group 0) and 17/34 (50%) patients with abdominal surgery (group 1). The most significant predictor was found for the logistic NTCP model with V16 Gy as the cutoff dose for group 0 and V40 Gy for group 1. Logistic regression NTCP model parameters were TV10≈ 290 cc for V16 Gy and TV10≈ 75 cc for V40 Gy, respectively.Conclusion. To keep the incidence of grade 2+acute small-bowel toxicity below 10%, we suggest that small-bowel volume above the prescription dose (V16 Gy) should be held to <290 cc for patients without abdominal surgery, and the prescription dose (V40 Gy) should be maintained <75 cc for patients with abdominal surgery.

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