Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection

Toxicology Letters ◽

10.1016/s0378-4274(02)00374-0 ◽

2003 ◽

Vol 138 (1-2) ◽

pp. 29-49 ◽

Author(s):

Frank-Peter Theil ◽

Theodor W Guentert ◽

Sami Haddad ◽

Patrick Poulin

Keyword(s):

Drug Discovery ◽

Drug Development ◽

Candidate Selection ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Rational Drug ◽

Physiologically Based

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Physiologically‐Based Pharmacokinetic Models as Enablers of Precision Dosing in Drug Development: Pivotal Role of the Human Mass Balance Study

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2092 ◽

2020 ◽

Vol 109 (1) ◽

pp. 51-54

Author(s):

Karen Rowland Yeo ◽

Karthik Venkatakrishnan

Keyword(s):

Drug Development ◽

Mass Balance ◽

Pivotal Role ◽

Pharmacokinetic Models ◽

Balance Study ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Mass Balance Study

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The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development

PROTEOMICS - CLINICAL APPLICATIONS ◽

10.1002/prca.201400147 ◽

2015 ◽

Vol 9 (7-8) ◽

pp. 732-744 ◽

Author(s):

Aki T. Heikkinen ◽

Floriane Lignet ◽

Paul Cutler ◽

Neil Parrott

Keyword(s):

Drug Development ◽

Small Molecule ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Small Molecule Drug ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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A Priori Prediction of Tissue:Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically‐Based Pharmacokinetic Models in Drug Discovery

Journal of Pharmaceutical Sciences ◽

10.1002/(sici)1520-6017(200001)89:1<16::aid-jps3>3.0.co;2-e ◽

2000 ◽

Vol 89 (1) ◽

pp. 16-35 ◽

Author(s):

Patrick Poulin ◽

Frank‐Peter Theil

Keyword(s):

Drug Discovery ◽

Partition Coefficients ◽

A Priori ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

Expert Opinion on Drug Metabolism & Toxicology ◽

10.1517/17425255.4.9.1143 ◽

2008 ◽

Vol 4 (9) ◽

pp. 1143-1152 ◽

Author(s):

Andrea N Edginton ◽

Frank-Peter Theil ◽

Walter Schmitt ◽

Stefan Willmann

Keyword(s):

Drug Development ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Clinical Drug Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

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How physiologically-based pharmacokinetic models should be improved for drug development

Future Medicinal Chemistry ◽

10.4155/fmc-2020-0074 ◽

2020 ◽

Author(s):

Georg Hempel

Keyword(s):

Drug Development ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Models Are Effective Support for Pediatric Drug Development

AAPS PharmSciTech ◽

10.1208/s12249-021-02076-w ◽

2021 ◽

Vol 22 (6) ◽

Author(s):

Kefei Wang ◽

Kun Jiang ◽

Xiaoyi Wei ◽

Yulan Li ◽

Tiejie Wang ◽

...

Keyword(s):

Drug Development ◽

Pharmacokinetic Models ◽

Pediatric Drug ◽

Physiologically Based Pharmacokinetic Models ◽

Pediatric Drug Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

Pediatric Anesthesia ◽

10.1111/j.1460-9592.2010.03323.x ◽

2011 ◽

Vol 21 (3) ◽

pp. 291-301 ◽

Author(s):

Trevor N. Johnson ◽

Amin Rostami-Hodjegan

Keyword(s):

Clinical Pharmacology ◽

Clinical Practice ◽

Drug Development ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Parallel Shift ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Pediatric Clinical Pharmacology

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Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph9051971 ◽

2012 ◽

Vol 9 (5) ◽

pp. 1971-1983 ◽

Author(s):

Susan C. Wason ◽

Thomas J. Smith ◽

Melissa J. Perry ◽

Jonathan I. Levy

Keyword(s):

Risk Assessment ◽

Cumulative Risk ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Pesticide Exposures ◽

Physiologically Based

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Response to “The Link Between Pharmacodynamics and Physiologically Based Pharmacokinetic Models”

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2012.216 ◽

2012 ◽

Vol 93 (2) ◽

pp. 152-152 ◽

Author(s):

A Rostami-Hodjegan

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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