Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

Expert Opinion on Drug Metabolism & Toxicology ◽

10.1517/17425255.4.9.1143 ◽

2008 ◽

Vol 4 (9) ◽

pp. 1143-1152 ◽

Author(s):

Andrea N Edginton ◽

Frank-Peter Theil ◽

Walter Schmitt ◽

Stefan Willmann

Keyword(s):

Drug Development ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Clinical Drug Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

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Physiologically‐Based Pharmacokinetic Models as Enablers of Precision Dosing in Drug Development: Pivotal Role of the Human Mass Balance Study

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2092 ◽

2020 ◽

Vol 109 (1) ◽

pp. 51-54

Author(s):

Karen Rowland Yeo ◽

Karthik Venkatakrishnan

Keyword(s):

Drug Development ◽

Mass Balance ◽

Pivotal Role ◽

Pharmacokinetic Models ◽

Balance Study ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Mass Balance Study

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The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development

PROTEOMICS - CLINICAL APPLICATIONS ◽

10.1002/prca.201400147 ◽

2015 ◽

Vol 9 (7-8) ◽

pp. 732-744 ◽

Author(s):

Aki T. Heikkinen ◽

Floriane Lignet ◽

Paul Cutler ◽

Neil Parrott

Keyword(s):

Drug Development ◽

Small Molecule ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Small Molecule Drug ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection

Toxicology Letters ◽

10.1016/s0378-4274(02)00374-0 ◽

2003 ◽

Vol 138 (1-2) ◽

pp. 29-49 ◽

Author(s):

Frank-Peter Theil ◽

Theodor W Guentert ◽

Sami Haddad ◽

Patrick Poulin

Keyword(s):

Drug Discovery ◽

Drug Development ◽

Candidate Selection ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Rational Drug ◽

Physiologically Based

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How physiologically-based pharmacokinetic models should be improved for drug development

Future Medicinal Chemistry ◽

10.4155/fmc-2020-0074 ◽

2020 ◽

Author(s):

Georg Hempel

Keyword(s):

Drug Development ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Reducing Whole Body Physiologically Based Pharmacokinetic Models Using Global Sensitivity Analysis: Diazepam Case Study

Journal of Pharmacokinetics and Pharmacodynamics ◽

10.1007/s10928-005-0004-8 ◽

2005 ◽

Vol 33 (1) ◽

pp. 1-27 ◽

Author(s):

Ivelina Gueorguieva ◽

Ivan A. Nestorov ◽

Malcolm Rowland

Keyword(s):

Sensitivity Analysis ◽

Global Sensitivity Analysis ◽

Pharmacokinetic Models ◽

Global Sensitivity ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Models Are Effective Support for Pediatric Drug Development

AAPS PharmSciTech ◽

10.1208/s12249-021-02076-w ◽

2021 ◽

Vol 22 (6) ◽

Author(s):

Kefei Wang ◽

Kun Jiang ◽

Xiaoyi Wei ◽

Yulan Li ◽

Tiejie Wang ◽

...

Keyword(s):

Drug Development ◽

Pharmacokinetic Models ◽

Pediatric Drug ◽

Physiologically Based Pharmacokinetic Models ◽

Pediatric Drug Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

Pediatric Anesthesia ◽

10.1111/j.1460-9592.2010.03323.x ◽

2011 ◽

Vol 21 (3) ◽

pp. 291-301 ◽

Author(s):

Trevor N. Johnson ◽

Amin Rostami-Hodjegan

Keyword(s):

Clinical Pharmacology ◽

Clinical Practice ◽

Drug Development ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Parallel Shift ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Pediatric Clinical Pharmacology

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Whole-body physiologically based pharmacokinetic models

Expert Opinion on Drug Metabolism & Toxicology ◽

10.1517/17425255.3.2.235 ◽

2007 ◽

Vol 3 (2) ◽

pp. 235-249 ◽

Author(s):

Ivan Nestorov

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Estimation of the minimum permeability for perfusion-limited distribution in whole-body physiologically based pharmacokinetic models

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2016.10.357 ◽

2017 ◽

Vol 32 (1) ◽

pp. S93

Author(s):

Yoo-Seong Jeong ◽

Chang-Soon Yim ◽

Heon-Min Ryu ◽

Jun-Hyeng Son ◽

Yoo-Kyung Song ◽

...

Keyword(s):

Pharmacokinetic Models ◽

Limited Distribution ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Linking preclinical and clinical whole-body physiologically based pharmacokinetic models with prior distributions in NONMEM

European Journal of Clinical Pharmacology ◽

10.1007/s00228-007-0264-x ◽

2007 ◽

Vol 63 (5) ◽

pp. 485-498 ◽

Author(s):

Grant Langdon ◽

Ivelina Gueorguieva ◽

Leon Aarons ◽

Mats Karlsson

Keyword(s):

Pharmacokinetic Models ◽

Prior Distributions ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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