Physiologically Based Pharmacokinetic Models Are Effective Support for Pediatric Drug Development

AAPS PharmSciTech ◽

10.1208/s12249-021-02076-w ◽

2021 ◽

Vol 22 (6) ◽

Author(s):

Kefei Wang ◽

Kun Jiang ◽

Xiaoyi Wei ◽

Yulan Li ◽

Tiejie Wang ◽

...

Keyword(s):

Drug Development ◽

Pharmacokinetic Models ◽

Pediatric Drug ◽

Physiologically Based Pharmacokinetic Models ◽

Pediatric Drug Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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State-of-the-Art Review on Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development

Clinical Pharmacokinetics ◽

10.1007/s40262-018-0677-y ◽

2018 ◽

Vol 58 (1) ◽

pp. 1-13 ◽

Author(s):

Venkata Yellepeddi ◽

Joseph Rower ◽

Xiaoxi Liu ◽

Shaun Kumar ◽

Jahidur Rashid ◽

...

Keyword(s):

Drug Development ◽

State Of The Art ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Pediatric Drug ◽

Pediatric Drug Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically‐Based Pharmacokinetic Models as Enablers of Precision Dosing in Drug Development: Pivotal Role of the Human Mass Balance Study

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.2092 ◽

2020 ◽

Vol 109 (1) ◽

pp. 51-54

Author(s):

Karen Rowland Yeo ◽

Karthik Venkatakrishnan

Keyword(s):

Drug Development ◽

Mass Balance ◽

Pivotal Role ◽

Pharmacokinetic Models ◽

Balance Study ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Mass Balance Study

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A best practice framework for applying physiologically‐based pharmacokinetic modeling to pediatric drug development

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12678 ◽

2021 ◽

Author(s):

Trevor N. Johnson ◽

Ben G. Small ◽

Eva Gil Berglund ◽

Karen Rowland Yeo

Keyword(s):

Drug Development ◽

Best Practice ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Pediatric Drug ◽

Pediatric Drug Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Practice Framework

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Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development

CPT Pharmacometrics & Systems Pharmacology ◽

10.1038/psp.2014.45 ◽

2014 ◽

Vol 3 (11) ◽

pp. 1-13 ◽

Author(s):

A R Maharaj ◽

A N Edginton

Keyword(s):

Drug Development ◽

Modeling And Simulation ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Pediatric Drug ◽

Pediatric Drug Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Pharmacokinetic Modeling And Simulation

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Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development: A Clinician’s Request for a More Integrated Approach

Journal of Biomedicine and Biotechnology ◽

10.1155/2012/103763 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3 ◽

Author(s):

Karel Allegaert ◽

Anne Smits ◽

Johannes N. van den Anker

Keyword(s):

Drug Development ◽

Integrated Approach ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Pediatric Drug ◽

Pediatric Drug Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development

PROTEOMICS - CLINICAL APPLICATIONS ◽

10.1002/prca.201400147 ◽

2015 ◽

Vol 9 (7-8) ◽

pp. 732-744 ◽

Author(s):

Aki T. Heikkinen ◽

Floriane Lignet ◽

Paul Cutler ◽

Neil Parrott

Keyword(s):

Drug Development ◽

Small Molecule ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Small Molecule Drug ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection

Toxicology Letters ◽

10.1016/s0378-4274(02)00374-0 ◽

2003 ◽

Vol 138 (1-2) ◽

pp. 29-49 ◽

Author(s):

Frank-Peter Theil ◽

Theodor W Guentert ◽

Sami Haddad ◽

Patrick Poulin

Keyword(s):

Drug Discovery ◽

Drug Development ◽

Candidate Selection ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Rational Drug ◽

Physiologically Based

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Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

Expert Opinion on Drug Metabolism & Toxicology ◽

10.1517/17425255.4.9.1143 ◽

2008 ◽

Vol 4 (9) ◽

pp. 1143-1152 ◽

Author(s):

Andrea N Edginton ◽

Frank-Peter Theil ◽

Walter Schmitt ◽

Stefan Willmann

Keyword(s):

Drug Development ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Clinical Drug Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

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How physiologically-based pharmacokinetic models should be improved for drug development

Future Medicinal Chemistry ◽

10.4155/fmc-2020-0074 ◽

2020 ◽

Author(s):

Georg Hempel

Keyword(s):

Drug Development ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling and Allometric Scaling in Pediatric Drug Development: Where Do We Draw the Line?

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1834 ◽

2021 ◽

Vol 61 (S1) ◽

Author(s):

Trevor N. Johnson ◽

Alice B. Ke

Keyword(s):

Drug Development ◽

Allometric Scaling ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Pediatric Drug ◽

Pediatric Drug Development ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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