Gas chromatographic—mass spectrometric analysis of organic acids in renal tissue biopsy

1982 ◽  
Vol 230 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Toshimitsu Niwa ◽  
Kenji Maeda ◽  
Hiroaki Asada ◽  
Masao Shibata ◽  
Toyokazu Ohki ◽  
...  
Keyword(s):  
Organic Acids ◽  
Renal Tissue ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis ◽  
Tissue Biopsy ◽  
Chromatographic Mass

Quantitative analysis for organic acids in biological samples: batch isolation followed by gas chromatographic-mass spectrometric analysis.

1989 ◽  
Vol 35 (4) ◽  
pp. 587-595 ◽  
Author(s):  
G Hoffmann ◽  
S Aramaki ◽  
E Blum-Hoffmann ◽  
W L Nyhan ◽  
L Sweetman
Keyword(s):  
Organic Acids ◽  
Amniotic Fluid ◽  
Biological Samples ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Rapid Screening ◽  
Chromatographic Retention ◽  
Spectrometric Analysis ◽  
Aldehydes And Ketones ◽  
Chromatographic Mass

Abstract This new method for qualitative and quantitative determination of organic acids, aldehydes, and ketones in biological samples is effective for use with urine, plasma, and amniotic fluid, and it requires no deproteinization. Isolation by batch-wise liquid partition chromatography on silicic acid follows formation of the O-(2,3,4,5,6-pentafluorobenzyl)oximes of oxoacids, aldehydes, and ketones. The total organic acid content of the sample provides a rapid screening test for metabolic abnormality. A wide-bore, bonded-phase capillary column was used for quantitative gas chromatographic-mass spectrometric analysis, followed by automated identification and quantification. Analytical recoveries were quantitative for a wide variety of metabolites. Gas-chromatographic retention indices, discriminating ions, and control ranges in amniotic fluid, plasma, and urine of adult subjects were determined for 61 biologically important compounds.

scholarly journals Gas Chromatographic-Mass Spectrometric Analysis of Volatiles Obtained by HS-SPME-GC-MS Technique from Aerial Parts of Ziziphora Capitata L., and Evaluation for Biological Activity.

2016 ◽  
Vol 32 (3) ◽  
pp. 1439-1451 ◽  
Author(s):  
Majid Mohammad hosseini ◽  
Abolfazl Akbarzadeh ◽  
Hamid Hashemi-Moghaddam ◽  
Mahdiyeh Shahnama ◽  
Bijan Fahimi ◽  
...  
Keyword(s):  
Biological Activity ◽  
Mass Spectrometric ◽  
Mass Spectrometric Analysis ◽  
Spectrometric Analysis ◽  
Aerial Parts ◽  
Chromatographic Mass
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