Simple and sensitive high-performance liquid chromatographic procedure with electrochemical detection for the determination of plasma concentrations of trimeprazine following single oral doses

1982 ◽  
Vol 233 (1) ◽  
pp. 417-422 ◽  
Author(s):  
G. McKay ◽  
J.K. Cooper ◽  
K.K. Midha ◽  
K. Hall ◽  
E.M. Hawes
Keyword(s):  
Electrochemical Detection ◽  
High Performance ◽  
Plasma Concentrations ◽  
High Performance Liquid Chromatographic ◽  
Chromatographic Procedure ◽  
Liquid Chromatographic ◽  
Oral Doses

Ascorbate in plasma as measured by liquid chromatography and by dichlorophenolindophenol colorimetry.

1986 ◽  
Vol 32 (6) ◽  
pp. 1004-1006 ◽  
Author(s):  
D J VanderJagt ◽  
P J Garry ◽  
W C Hunt
Keyword(s):  
Ascorbic Acid ◽  
Liquid Chromatography ◽  
Electrochemical Detection ◽  
High Performance ◽  
Colorimetric Method ◽  
Dehydroascorbic Acid ◽  
High Performance Liquid Chromatographic ◽  
Plasma Samples ◽  
Chromatographic Procedure ◽  
Liquid Chromatographic

Abstract Ascorbic acid was measured in 125 plasma samples by an automated colorimetric method involving dichlorophenolindophenol and by a "high-performance" liquid-chromatographic procedure with electrochemical detection. The two methods gave comparable results for samples with ascorbate concentrations of 1 to 20 mg/L (r = 0.97). We also measured the amount of total ascorbate (ascorbic acid + dehydroascorbic acid) in the same samples by a liquid-chromatographic procedure with precolumn derivitization of ascorbic acid. We confirmed that plasma contains little dehydroascorbic acid.

Reverse Phase High Performance Liquid Chromatographic Determination of Phenprocoumon in Tablets

1982 ◽  
Vol 65 (3) ◽  
pp. 753-756
Author(s):  
Walter F Schmidt
Keyword(s):  
High Performance ◽  
Internal Standard ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Reverse Phase ◽  
Assay Procedure ◽  
Chromatographic Procedure ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract A high performance liquid chromatographic procedure has been developed for the assay of phenprocoumon in tablets. In comparison to the present official USP assay procedure, it is equivalent in precision and accuracy and is faster and more specific. A mobile phase consisting of a 1% solution of acetic acid in acetonitrile-water (4 + 3) separates phenprocoumon from warfarin internal standard on a 6 μm octadecylsilane (ODS) column with UV detection at 311 nm. The method enables the concurrent determination of phenprocoumon and possible contaminants such as salicylic acid.

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