Determination of picogram levels of a novel α2-adrenergic receptor antagonist in plasma using solid-phase extraction and capillary gas chromatography with nitrogen-selective detection

1989 ◽  
Vol 488 (2) ◽  
pp. 476-481
Author(s):  
M.L. Constanzer ◽  
B.K. Matuszewski ◽  
J.K. Hsieh ◽  
W.F. Bayne
Keyword(s):  
Gas Chromatography ◽  
Solid Phase Extraction ◽  
Receptor Antagonist ◽  
Capillary Gas Chromatography ◽  
Adrenergic Receptor ◽  
Solid Phase ◽  
Selective Detection ◽  
Phase Extraction

scholarly journals Simultaneous Determination of Imazalil and Its Major Metabolite in Citrus Fruit by Solid-Phase Extraction and Capillary Gas Chromatography with Electron Capture Detection

2001 ◽  
Vol 84 (2) ◽  
pp. 546-550 ◽  
Author(s):  
Hisashi Matsumoto
Keyword(s):  
Gas Chromatography ◽  
Solid Phase Extraction ◽  
Simultaneous Determination ◽  
Capillary Gas Chromatography ◽  
Solid Phase ◽  
Citrus Fruit ◽  
Electron Capture Detection ◽  
Phase Extraction ◽  
Spe Method

Abstract A method was developed for the simultaneous determination of imazalil and its major metabolite, R 14821, in citrus fruit. This method (designated the SPE method) is based on solid-phase extraction (SPE) and capillary gas chromatography (GC) with electron-capture detection (ECD). The SPE method is highly sensitive for both compounds (limit of detection for each: 0.001 μg/g) and is less time consuming than the previously reported method based on repeated liquid–liquid partitioning and GC–ECD. Recoveries for 3 levels of fortification (0.02, 0.2, and 2.5 μg/g) from satsuma mandarins ranged from 94.3 to 96.5% for imazalil and from 93.9 to 96.3% for R 14821, with coefficients of variation (CVs) ranging from 3.1 to 6.3% for imazalil and from 4.5 to 5.6% for R 14821. Average residual levels found in grapefruit, oranges, and lemons by the SPE method and the previously reported method, and the corresponding CVs, were similar.

Measurement of Antidepressants Using Solid-Phase Extraction and Wide-Bore Capillary Gas Chromatography with Nitrogen-Selective Detection

1988 ◽  
Vol 10 (2) ◽  
pp. 194-196 ◽  
Author(s):  
Nader Rifai ◽  
Cheryl M. Howlett ◽  
Cyndy B. Levtzow ◽  
Julius C. Phillips ◽  
Nancy C. Parker ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Solid Phase Extraction ◽  
Capillary Gas Chromatography ◽  
Solid Phase ◽  
Selective Detection ◽  
Phase Extraction
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