Determination of ethylenediaminetetra-acetic acid in aqueous rinses of detergent-washed rubber stoppers of pharmaceutical vials using solid-phase extraction and capillary gas chromatography

1987 ◽  
Vol 5 (7) ◽  
pp. 687-694 ◽  
Author(s):  
Michael A. Ribick ◽  
Mohammed Jemal ◽  
Allen I. Cohen
Keyword(s):  
Gas Chromatography ◽  
Acetic Acid ◽  
Solid Phase Extraction ◽  
Capillary Gas Chromatography ◽  
Solid Phase ◽  
Phase Extraction

scholarly journals Simultaneous Determination of Imazalil and Its Major Metabolite in Citrus Fruit by Solid-Phase Extraction and Capillary Gas Chromatography with Electron Capture Detection

2001 ◽  
Vol 84 (2) ◽  
pp. 546-550 ◽  
Author(s):  
Hisashi Matsumoto
Keyword(s):  
Gas Chromatography ◽  
Solid Phase Extraction ◽  
Simultaneous Determination ◽  
Capillary Gas Chromatography ◽  
Solid Phase ◽  
Citrus Fruit ◽  
Electron Capture Detection ◽  
Phase Extraction ◽  
Spe Method

Abstract A method was developed for the simultaneous determination of imazalil and its major metabolite, R 14821, in citrus fruit. This method (designated the SPE method) is based on solid-phase extraction (SPE) and capillary gas chromatography (GC) with electron-capture detection (ECD). The SPE method is highly sensitive for both compounds (limit of detection for each: 0.001 μg/g) and is less time consuming than the previously reported method based on repeated liquid–liquid partitioning and GC–ECD. Recoveries for 3 levels of fortification (0.02, 0.2, and 2.5 μg/g) from satsuma mandarins ranged from 94.3 to 96.5% for imazalil and from 93.9 to 96.3% for R 14821, with coefficients of variation (CVs) ranging from 3.1 to 6.3% for imazalil and from 4.5 to 5.6% for R 14821. Average residual levels found in grapefruit, oranges, and lemons by the SPE method and the previously reported method, and the corresponding CVs, were similar.

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