In vitro evaluation of dry powder inhalers II: influence of carrier particle size and concentration on in vitro deposition

1997 ◽  
Vol 154 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Hartwig Steckel ◽  
Bernd W Müller
Keyword(s):  
Particle Size ◽  
Dry Powder Inhalers ◽  
Dry Powder ◽  
In Vitro Evaluation

scholarly journals Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products

2018 ◽  
Vol 113 ◽  
pp. 18-28 ◽  
Author(s):  
Sitaram P. Velaga ◽  
Jelena Djuris ◽  
Sandra Cvijic ◽  
Stavroula Rozou ◽  
Paola Russo ◽  
...  
Keyword(s):  
In Vitro Dissolution ◽  
Dry Powder Inhalers ◽  
Dry Powder ◽  
Drug Products

scholarly journals Formulation, characterization and evaluation of nanoparticles based dry powder insufflation containing terbutaline sulphate and itraconazole for the treatment of asthma

2020 ◽  
Vol 11 (1) ◽  
pp. 567-580
Author(s):  
Venugopalaiah Penabaka ◽  
Kumar B ◽  
Prasad N.B.L
Keyword(s):  
Particle Size ◽  
Size Distribution ◽  
Bronchial Asthma ◽  
Spherical Particles ◽  
Dry Powder ◽  
Terbutaline Sulphate ◽  
Release Studies ◽  
Physical Mixing ◽  
Spray Dried

Many factors affect the pulmonary drug delivery and stability of the nanoparticles an acupuncture consisting of bronchial asthma. Present research envisages on the development of dry powder nanoparticles as insufflation a acupuncture consisting of bronchial asthma (allergy due to Aspergillus fumigatus) using physical mixing and spray drying. Different founding are prepared and characterized with suitable excipients like lactose and trehalose. The particle size distribution of nano milled and spray-dried particles of Terbutaline Sulphate and Itraconazole showed unimodal size distribution. The formulations prepared with trehalose as the carrier showed less Dv90, Dv50 and Dv10 values due to the fineness in the particles of trehalose when compared to lactose. The Dv50  and Dv10 values were in the range of mountains of 0.43-0.89 µm and 0.21–0.49 µm for all formulations, which shows the primary particle size in the nanometer scale. Smooth and nearly spherical particles were produced for spray-dried formulations when compared to milled formulations. Zeta potential comes across until be between +17±0.13 to +32±0.12, which explains the particles as moderately stable. MMAD values ranges from 3.19 µm to 4.78 µm for milled nanoparticles and 3.45 µm to 4.21 µm for spray-dried particles. Formulated nanoparticles exhibited good spreading properties, which will allow all the particles to deposition palmy profusion territories consisting of the lung. In-vitro drug release studies explains that spray-dried formulations of Terbutaline sulpahte and Itraconazole using lactose as excipients released the drug upto 98.9% and 99.1% in 180mts.

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