5589061 Process for the preparation of cellulose based chiral separation liquid chromatography stationary phase

1997 ◽  
Vol 15 (2) ◽  
pp. 483
Keyword(s):  
Liquid Chromatography ◽  
Stationary Phase ◽  
Chiral Separation

Chiral Separation of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-di -hydropyrimidin- 2(1H)-thiones Enantiomers by HPLC on Chiralcel®OD-H

2020 ◽  
Vol 16 (3) ◽  
pp. 250-255
Author(s):  
Noura Kichou ◽  
Ismahan Rahou ◽  
Zaid M. Elamin ◽  
Khaled Sekkoum ◽  
Nasser Belboukhari ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Stationary Phase ◽  
Chiral Separation ◽  
Chiral Stationary Phase ◽  
Normal Phase ◽  
Good Resolution ◽  
Mode Structure ◽  
Structure Retention ◽  
Short Time

Objective: Ten racemic 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin- 2(1H)-thiones were separated by liquid chromatography on Chiralcel®OD-H column containing cellulose tris(3, 5-dimethylphenylcarbamate). Methods: The enantioseparation was carried out using Chiralcel®OD-H polysaccharide-type chiral stationary phase to resolve such enantiomers under normal-phase mode. Results: Complete separations of the 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin- 2(1H)-thiones derivatives with good resolution (RS= 1.04-2.80) were achieved within a short time (10-15 min). Conclusion: An optimal baseline separation (Rs> 1.5) was achieved using Chiralcel®OD-H under normal-phase mode. Structure-retention relationships have also been discussed.

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