Prenatal alcohol exposure decreases the number of nitric oxide synthase positive neurons in rat superior colliculus and periaqueductal gray

Alcohol ◽  
2000 ◽  
Vol 22 (2) ◽  
pp. 75-84 ◽  
Author(s):  
Dwight E Phillips ◽  
Joel D Cummings ◽  
Kenneth A Wall
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Superior Colliculus ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Periaqueductal Gray ◽  
Prenatal Alcohol ◽  
Oxide Synthase

Acupuncture decreases nitric oxide synthase expression in periaqueductal gray area of rats with streptozotocin-induced diabetes

2003 ◽  
Vol 337 (3) ◽  
pp. 155-158 ◽  
Author(s):  
Mi-Hyeon Jang ◽  
Min-Chul Shin ◽  
Gyo-Sung Koo ◽  
Choong-Yeol Lee ◽  
Ee-Hwa Kim ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Periaqueductal Gray ◽  
Gray Area ◽  
Streptozotocin Induced Diabetes ◽  
Oxide Synthase

scholarly journals Asymmetric Dimethylarginine Blocks Nitric Oxide-Mediated Alcohol-Stimulated Cilia Beating

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
T. A. Wyatt ◽  
S. M. Wells ◽  
Z. A. Alsaidi ◽  
J. M. DeVasure ◽  
E. B. Klein ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Epithelial Cells ◽  
Asymmetric Dimethylarginine ◽  
Beat Frequency ◽  
Alcohol Exposure ◽  
Bronchial Epithelial Cells ◽  
Mouse Lung ◽  
Bronchial Epithelial ◽  
Oxide Synthase

The airway epithelium is exposed to alcohol during drinking through direct exhalation of volatized ethanol from the bronchial circulation. Alcohol exposure leads to a rapid increase in the cilia beat frequency (CBF) of bronchial epithelial cells followed by a chronic desensitization of cilia stimulatory responses. This effect is governed in part by the nitric oxide regulation of cyclic guanosine and adenosine monophosphate-dependent protein kinases (PKG and PKA) and is not fully understood. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is implicated in the pathogenesis of several pulmonary disorders. We hypothesized that the inhibition of nitric oxide synthase by ADMA blocks alcohol-stimulated increases in CBF. To test this hypothesis, ciliated primary bovine bronchial epithelial cells (BBEC) were preincubated with ADMA (100 µM) and stimulated with 100 mM ethanol. CBF was measured and PKA assayed. By 1 hr, ethanol activated PKA, resulting in elevated CBF. Both alcohol-induced PKA activation and CBF were inhibited in the presence of ADMA. ADMA alone had no effect on PKA activity or CBF. Using a mouse model overexpressing the ADMA-degrading enzyme, dimethylarginine dimethylaminohydrolase (DDAH), we examined PKA and CBF in precision-cut mouse lung slices. Alcohol-stimulated increases in lung slice PKA and CBF were temporally enhanced in the DDAH mice versus control mice.

Nitric Oxide Synthase Expression in the Opossum Superior Colliculus: A Histochemical, Immunohistochemical and Biochemical Study

1999 ◽  
Vol 54 (6) ◽  
pp. 303-313 ◽  
Author(s):  
Arthur Giraldi-Guimarães ◽  
Frank Tenório ◽  
Gerold Brüning ◽  
Bernd Mayer ◽  
Rosalia Mendez-Otero ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Superior Colliculus ◽  
Biochemical Study ◽  
Oxide Synthase

Developmental changes of nitric oxide synthase in the rat superior colliculus

1995 ◽  
Vol 42 (5) ◽  
pp. 633-637 ◽  
Author(s):  
F. Tenório ◽  
A. Giraldi-Guimarães ◽  
R. Mendez-Otero
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Superior Colliculus ◽  
Developmental Changes ◽  
Oxide Synthase
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