126 POSTER The ratio between metastatic and examined lymph nodes (N-ratio) is an independent prognostic factor in gastric cancer regardless of the type of lymphadenectomy: results from an Italian multicentric study in 1,853 patients

2006 ◽  
Vol 32 ◽  
pp. S38
Author(s):  
S. Mocellin ◽  
A. Marchet ◽  
A. Ambrosi ◽  
P. Morgagni ◽  
F. Roviello ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factor ◽  
Lymph Nodes ◽  
Independent Prognostic Factor ◽  
Multicentric Study

scholarly journals Study of Survival in Gastric Cancer with Emphasis on Lymph Node Status as an Independent Prognostic Factor

2019 ◽  
Vol 4 (4) ◽  
pp. 185-189
Author(s):  
Nicolae Suciu ◽  
Orsolya Bauer ◽  
Zalán Benedek ◽  
Radu Ghenade ◽  
Marius Coroș ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Nodes ◽  
Vascular Invasion ◽  
Lymph Node Ratio ◽  
Independent Prognostic Factor ◽  
Lymph Node Status ◽  
Node Ratio ◽  
Gastric Cancer Patients

Abstract Background: Lymph node status in gastric cancer is known as an independent prognostic factor that guides the surgical and oncological treatment and independently influences long-term survival. Several studies suggest that the lymph node ratio has a greater importance in survival than the number of metastatic lymph nodes. Aim: The aim of this study was to evaluate the clinical and morphological factors that can influence the survival of gastric cancer patients, with an emphasis on nodal status and the lymph node ratio. Material and methods: We conducted a retrospective study in which 303 patients with gastric cancer admitted to the Department of Surgery of the Mureș County Hospital between 2008 and 2018 were screened for study enrolment. Data were obtained from the records of the department and from the histopathological reports. The examined variables included: age, gender, tumor localization, T stage, histological type, grade of differentiation, surgical procedure, lympho-vascular invasion, excised lymph nodes, metastatic lymph nodes, lymph node ratio. After screening, the study included a total number of 100 patients, for which follow-up data was available. Results: The mean age of the study population was 66.43 ± 10 years, and 71% were males. The average survival period was 21.42 months. Statistical analysis showed that the localization of the tumor (p = 0.021), vascular invasion (p ---lt---0.001), T (p = 0.004) and N (p ---lt---0.001) stages, type of surgery (partial gastrectomy 59% vs. total gastrectomy 41%, p = 0.005), as well as the lymph node ratio (p ---lt---0.001) were prognostic factors for survival in patients with gastric cancer undergoing surgical therapy. Conclusions: The survival of gastric cancer patients is significantly influenced by tumor localization, T stage, vascular invasion, type of surgery, N stage and the lymph node ratio based on univariate analysis. Also, the lymph node ratio proved to be an independent prognostic factor for survival.

Ratio Between Metastatic and Examined Lymph Nodes Is an Independent Prognostic Factor After D2 Resection for Gastric Cancer: Analysis of a Large European Monoinstitutional Experience

2003 ◽  
Vol 10 (9) ◽  
pp. 1077-1085 ◽  
Author(s):  
Donato Nitti ◽  
Alberto Marchet ◽  
Matteo Olivieri ◽  
Alessandro Ambrosi ◽  
Roberto Mencarelli ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factor ◽  
Lymph Nodes ◽  
Independent Prognostic Factor

scholarly journals The Ratio Between Metastatic and Examined Lymph Nodes (N Ratio) Is an Independent Prognostic Factor in Gastric Cancer Regardless of the Type of Lymphadenectomy

2007 ◽  
Vol 245 (4) ◽  
pp. 543-552 ◽  
Author(s):  
Alberto Marchet ◽  
Simone Mocellin ◽  
Alessandro Ambrosi ◽  
Paolo Morgagni ◽  
Domenico Garcea ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factor ◽  
Lymph Nodes ◽  
Independent Prognostic Factor

scholarly journals The Role of the Lymph Node Ratio in Advanced Gastric Cancer After Neoadjuvant Chemotherapy

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1914 ◽  
Author(s):  
Karol Rawicz-Pruszyński ◽  
Bogumiła Ciseł ◽  
Radosław Mlak ◽  
Jerzy Mielko ◽  
Magdalena Skórzewska ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factor ◽  
Neoadjuvant Chemotherapy ◽  
Lymph Nodes ◽  
Tumor Regression ◽  
Surgical Oncology ◽  
Independent Prognostic Factor ◽  
Tumor Diameter ◽  
Histological Subtype ◽  
The Impact

The ratio of positive lymph nodes (LNs) to the total LN harvest is called the LN ratio (LNR). It is an independent prognostic factor in gastric cancer (GC). The aim of the current study was to evaluate the impact of neoadjuvant chemotherapy (NAC) on the LNR (ypLNR) in patients with advanced GC. We retrospectively analyzed the data of patients with advanced GC, who underwent gastrectomy with N1 and N2 (D2) lymphadenectomy between August 2011 and January 2019 in the Department of Surgical Oncology at the Medical University of Lublin. The exclusion criteria were a lack of preoperative NAC administration, suboptimal lymphadenectomy (<D2 and/or removal of less than 15 lymph nodes), and a lack of data on tumor regression grading (TRG) in the final pathological report. A total of 95 patients were eligible for the analysis. A positive correlation was found between the ypLNR and tumor diameter (p < 0.001), post treatment pathological Tumour (ypT) stage (p < 0.001), Laurén histological subtype (p = 0.0001), and the response to NAC (p < 0.0001). A multivariate analysis demonstrated that the ypLNR was an independent prognostic factor in patients with intestinal type GC (p = 0.0465) and in patients with no response to NAC (p = 0.0483). In the resection specimen, tumor diameter and depth of infiltration, Laurén histological subtype, and TRG may reflect the impact of NAC on LN status, as quantified by ypLNR in advanced GC.

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