5-HT4 receptors: long-term blockade of K+ channels and effects on olfactory memory

The characteristics of olfactory memory during development were investigated and the hypothesis that the pleasantness of smells may be affected by previous associations with pleasant or unpleasant objects or events was tested. This type of emotional memory was compared in the immediate and long-term recognition of olfactory stimuli. Children from three different age groups (mean ages: 6 years 6 months; 8 years 9 months; and 10 years 5 months) were subdivided into two groups. One group was presented with six different odours, each with a slide depicting a pleasant picture. The other group was presented with the odours accompanied by unpleasant pictures. Immediately after stimulus presentation the subjects underwent a recognition test. One month later the subjects underwent a second recognition test, at the end of which they were required to give an evaluation of the pleasantness of each odour on a nine-point scale. At no age level did the pictures matched to the odours affect the recognition score. Olfactory memory varied with age, chiefly because memory decay increased with age, perhaps because of greater proactive interference. With increasing age more rapid decay was set against better immediate recognition. The hypothesis that the hedonic characteristics of odours are partially learned and are affected by events experienced in other modalities was supported.

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Elongator complex is required for long-term olfactory memory formation in Drosophila

Learning & Memory ◽

10.1101/lm.046557.117 ◽

2018 ◽

Vol 25 (4) ◽

pp. 183-196 ◽

Cited By ~ 2

Author(s):

Dinghui Yu ◽

Ying Tan ◽

Molee Chakraborty ◽

Seth Tomchik ◽

Ronald L. Davis

Keyword(s):

Memory Formation ◽

Olfactory Memory ◽

Elongator Complex

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Differential conditioning and long-term olfactory memory in individual Camponotus fellah ants

Journal of Experimental Biology ◽

10.1242/jeb.030080 ◽

2009 ◽

Vol 212 (12) ◽

pp. 1904-1911 ◽

Cited By ~ 31

Author(s):

R. Josens ◽

C. Eschbach ◽

M. Giurfa

Keyword(s):

Differential Conditioning ◽

Olfactory Memory ◽

Camponotus Fellah

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Formation of long term olfactory memory in honeybees does not require protein synthesis

The Science of Nature ◽

10.1007/bf01138799 ◽

1993 ◽

Vol 80 (8) ◽

pp. 380-382 ◽

Cited By ~ 12

Author(s):

R. Menzel ◽

U. C. Gaio ◽

M. Gerberding ◽

E. A. Nerarava ◽

S. Wittstock

Keyword(s):

Protein Synthesis ◽

Olfactory Memory

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Evidence of involvement of GIRK1/GIRK4 in long-term desensitization of cardiac muscarinic K+channels

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.2001.280.6.h2554 ◽

2001 ◽

Vol 280 (6) ◽

pp. H2554-H2562 ◽

Cited By ~ 9

Author(s):

Zhigang Shui ◽

Tomoko Takahashi Yamanushi ◽

Mark R. Boyett

Keyword(s):

G Protein ◽

Muscarinic Receptor ◽

Neonatal Rat ◽

Channel Activity ◽

Channel System ◽

K Channels ◽

Atrial Cells ◽

Inside Out ◽

Rat Atrial Cells

The cardiac M2 muscarinic receptor/G protein/K+ channel system was studied in neonatal rat atrial cells cultured with and without 10 μM carbachol (CCh) for 24 h. Channel activity in CCh-pretreated cells was substantially reduced as a result of long-term desensitization regardless of whether the channel was activated by ACh in cell-attached patches or GTP in inside-out patches. Channel activity in CCh-pretreated cells was also low when the receptor was bypassed and the G protein and channel were directly activated by [γ-S]GTP or both the receptor and G protein were bypassed and the channel was directly activated by trypsin. Finally, in CCh-pretreated cells, the whole cell K+ current was low when the channel was activated via the independent adenosine receptor. This suggests that the channel is involved in long-term desensitization. However, in CCh-pretreated cells, although the receptor was internalized, there was no internalization of the channel. We suggest that the function of the muscarinic K+ channel declines in long-term desensitization of the cardiac M2 muscarinic receptor/G protein/K+ channel system.

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