Poster #S22 THE ANTI-ANHEDONIC PROPERTIES OF LURASIDONE IN THE CHRONIC MILD STRESS MODEL ARE ASSOCIATED WITH SYNAPTIC AND NEUROPLASTIC CHANGES IN THE RAT PREFRONTAL CORTEX

2014 ◽  
Vol 153 ◽  
pp. S95-S96
Author(s):  
Marco A. Riva ◽  
Flavia Macchi ◽  
Andrea C. Rossetti ◽  
Mariusz Papp ◽  
Raffaella Molteni
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model

scholarly journals Analysis of Antidepressant-like Effects and Action Mechanisms of GSB-106, a Small Molecule, Affecting the TrkB Signaling

2021 ◽  
Vol 22 (24) ◽  
pp. 13381
Author(s):  
Yulia V. Vakhitova ◽  
Tatiana S. Kalinina ◽  
Liana F. Zainullina ◽  
Anastasiya Yu. Lusta ◽  
Anna V. Volkova ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Mild Stress ◽  
Tail Suspension Test ◽  
Brain Structures ◽  
Mild Stress ◽  
Stress Model ◽  
Pronounced Increase ◽  
Unpredictable Chronic Mild Stress ◽  
Porsolt Test ◽  
Action Mechanisms

Induction of BDNF-TrkB signaling is associated with the action mechanisms of conventional and fast-acting antidepressants. GSB-106, developed as a small dimeric dipeptide mimetic of BDNF, was previously shown to produce antidepressant-like effects in the mouse Porsolt test, tail suspension test, Nomura water wheel test, in the chronic social defeat stress model and in the inflammation-induced model of depression. In the present study, we evaluated the effect of chronic per os administration of GSB-106 to Balb/c mice under unpredictable chronic mild stress (UCMS). It was observed for the first time that long term GSB-106 treatment (1 mg/kg, 26 days) during ongoing UCMS procedure ameliorated the depressive-like behaviors in mice as indicated by the Porsolt test. In addition, chronic per os administration of GSB-106 resulted in an increase in BDNF levels, which were found to be decreased in the prefrontal cortex and hippocampus of mice after UCMS. Furthermore, prolonged GSB-106 treatment was accompanied by an increase in the content of pTrkB706/707 in the prefrontal cortex and by a pronounced increase in the level of pTrkB816 in both studied brain structures of mice subjected to UCMS procedure. In summary, the present data show that chronic GSB-106 treatment produces an antidepressant-like effect in the unpredictable chronic mild stress model, which is likely to be associated with the regulation of the BDNF-TrkB signaling.

Desipramine increased experimental lung tumor growth in stress-sensitive rats in the chronic mild stress model of depression

2010 ◽  
Vol 62 ◽  
pp. 50
Author(s):  
Marta Kubera ◽  
Beata Grygier ◽  
Danuta Wrona ◽  
Piotr Gruca ◽  
Zofia Rogóz ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Tumor ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model

scholarly journals Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism

2012 ◽  
Vol 4 (4) ◽  
pp. 627-632 ◽  
Author(s):  
JING-MEI ZHONG ◽  
SHAO-YUAN WU ◽  
JIE BAI ◽  
QIANG GUO ◽  
JIAN TAO ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Antidepressant Effect ◽  
Mild Stress ◽  
Stress Model

Mesolimbic dopamine system and its modulation by vitamin D in a chronic mild stress model of depression in the rat

2019 ◽  
Vol 356 ◽  
pp. 156-169 ◽  
Author(s):  
Katayoun Sedaghat ◽  
Zahra Yousefian ◽  
Abbas Ali Vafaei ◽  
Ali Rashidy-Pour ◽  
Houman Parsaei ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model ◽  
Mesolimbic Dopamine ◽  
Dopamine System ◽  
Mesolimbic Dopamine System

Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression

2017 ◽  
Vol 134 ◽  
pp. 211-219 ◽  
Author(s):  
Ying Ren ◽  
Jin-Liang Wang ◽  
Xiang Zhang ◽  
Hao Wang ◽  
Ying Ye ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model

Exploring the astrocytic neuroprotective functions in a chronic mild stress model of depression

2017 ◽  
Vol 27 ◽  
pp. S31-S32
Author(s):  
J.S. Correia ◽  
P. Patrício ◽  
N.D. Alves ◽  
A.R. Santos ◽  
M. Morais ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model

scholarly journals Antidepressant-like effect of salidroside and curcumin on the immunoreactivity of rats subjected to a chronic mild stress model

2018 ◽  
Vol 121 ◽  
pp. 604-611 ◽  
Author(s):  
Liliya V. Vasileva ◽  
Kremena E. Saracheva ◽  
Mariya V. Ivanovska ◽  
Atanaska P. Petrova ◽  
Andrey S. Marchev ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model

The role of prefrontal cortex dopamine D2 and D3 receptors in the mechanism of action of venlafaxine and deep brain stimulation in animal models of treatment-responsive and treatment-resistant depression

2019 ◽  
Vol 33 (6) ◽  
pp. 748-756 ◽  
Author(s):  
Mariusz Papp ◽  
Piotr Gruca ◽  
Magdalena Lason ◽  
Monika Niemczyk ◽  
Paul Willner
Keyword(s):  
Prefrontal Cortex ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Memory Consolidation ◽  
Wistar Rats ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Wistar Kyoto Rats ◽  
Wistar Kyoto ◽  
Deep Brain

Aims: The Wistar-Kyoto rat has been validated as an animal model of treatment-resistant depression. Here we investigated a role of dopamine D2 and D3 receptors in the ventro-medial prefrontal cortex in the mechanism of action of deep brain stimulation in Wistar-Kyoto rats and venlafaxine in Wistar rats. Methods: Wistar or Wistar-Kyoto rats were exposed chronically to chronic mild stress. Wistar rats were treated chronically with venlafaxine (10 mg/kg) beginning after two weeks of chronic mild stress; Wistar-Kyoto rats received two sessions of deep brain stimulation before behavioural tests. L-742,626 (1 µg), a D2 receptor agonist, or 7-OH DPAT (3 µg), a D3 receptor antagonist, were infused into the ventro-medial prefrontal cortex immediately following the exposure trial in the Novel Object Recognition Test, and discrimination between novel and familiar object was tested one hour later. Results: Chronic mild stress decreased sucrose intake and impaired memory consolidation; these effects were reversed by venlafaxine in Wistar rats and deep brain stimulation in Wistar-Kyoto rats. In control animals, L-742,626 and 7-OH DPAT also impaired memory consolidation. In Wistar rats, venlafaxine reversed the effect of L-742,626 in controls, but not in the chronic mild stress group, and venlafaxine did not reverse the effect of 7-OH DPAT in either group. In Wistar-Kyoto rats, deep brain stimulation reversed the effect of both L-742,626 and 7-OH DPAT in both control and chronic mild stress groups. Conclusions: We conclude that the action of venlafaxine to reverse the impairment of memory consolidation caused by chronic mild stress in Wistar rats involves D2 receptors in the ventro-medial prefrontal cortex; but the effect of deep brain stimulation to reverse the same effect in Wistar-Kyoto rats does not.

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