scholarly journals Analysis of Antidepressant-like Effects and Action Mechanisms of GSB-106, a Small Molecule, Affecting the TrkB Signaling

2021 ◽  
Vol 22 (24) ◽  
pp. 13381
Author(s):  
Yulia V. Vakhitova ◽  
Tatiana S. Kalinina ◽  
Liana F. Zainullina ◽  
Anastasiya Yu. Lusta ◽  
Anna V. Volkova ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Mild Stress ◽  
Tail Suspension Test ◽  
Brain Structures ◽  
Mild Stress ◽  
Stress Model ◽  
Pronounced Increase ◽  
Unpredictable Chronic Mild Stress ◽  
Porsolt Test ◽  
Action Mechanisms

Induction of BDNF-TrkB signaling is associated with the action mechanisms of conventional and fast-acting antidepressants. GSB-106, developed as a small dimeric dipeptide mimetic of BDNF, was previously shown to produce antidepressant-like effects in the mouse Porsolt test, tail suspension test, Nomura water wheel test, in the chronic social defeat stress model and in the inflammation-induced model of depression. In the present study, we evaluated the effect of chronic per os administration of GSB-106 to Balb/c mice under unpredictable chronic mild stress (UCMS). It was observed for the first time that long term GSB-106 treatment (1 mg/kg, 26 days) during ongoing UCMS procedure ameliorated the depressive-like behaviors in mice as indicated by the Porsolt test. In addition, chronic per os administration of GSB-106 resulted in an increase in BDNF levels, which were found to be decreased in the prefrontal cortex and hippocampus of mice after UCMS. Furthermore, prolonged GSB-106 treatment was accompanied by an increase in the content of pTrkB706/707 in the prefrontal cortex and by a pronounced increase in the level of pTrkB816 in both studied brain structures of mice subjected to UCMS procedure. In summary, the present data show that chronic GSB-106 treatment produces an antidepressant-like effect in the unpredictable chronic mild stress model, which is likely to be associated with the regulation of the BDNF-TrkB signaling.

scholarly journals Utility of the chronic unpredictable mild stress model in research on new antidepressants

2014 ◽  
Vol 27 (2) ◽  
pp. 97-101 ◽  
Author(s):  
Karolina Pekala ◽  
Barbara Budzynska ◽  
Grazyna Biala
Keyword(s):  
Depressive Disorders ◽  
Prolonged Exposure ◽  
Chronic Mild Stress ◽  
Depressive Illness ◽  
Accurate Diagnosis ◽  
Mild Stress ◽  
Stress Model ◽  
Chronic Unpredictable Mild Stress ◽  
Unpredictable Chronic Mild Stress ◽  
Animal Model Of Depression

Abstract Unpredictable chronic mild stress model was developed as an animal model of depression more than 20 years ago. Essential for this model is that after prolonged exposure of tested animals to a series of unpredictable mild stressors, a condition similar to anhedonia develops, which is observed in the majority of depressive disorders. Unpredictable chronic mild stress model is used nowadays in numerous studies related to the neurobiological and biochemical changes associated with depressive illness. Their results confirm that chronic unpredictable mild stress induces in tested animals a number of changes, which reflect those seen in depressive disorders. Because the effects of unpredictable chronic mild stress can be used in a more accurate diagnosis of the pathophysiology of depressive illness and expand knowledge of its pharmacotherapy, therefore research in this area has been continued all the time.

The Link Between Unpredictable Chronic Mild Stress Model for Depression and Vascular Inflammation?

Inflammation ◽  
2014 ◽  
Vol 37 (5) ◽  
pp. 1432-1438 ◽  
Author(s):  
Tuğçe Demirtaş ◽  
Tijen Utkan ◽  
Ayşe Karson ◽  
Yusufhan Yazır ◽  
Dilek Bayramgürler ◽  
...  
Keyword(s):  
Vascular Inflammation ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model ◽  
Unpredictable Chronic Mild Stress

Antidepressant-like effects of the saponins extracted from Chaihu-jia-longgu-muli-tang in a rat unpredictable chronic mild stress model

Fitoterapia ◽  
2012 ◽  
Vol 83 (1) ◽  
pp. 93-103 ◽  
Author(s):  
Lu-Fan Li ◽  
Jie Lu ◽  
Xiu-Min Li ◽  
Chang-Liang Xu ◽  
Jie Yang ◽  
...  
Keyword(s):  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model ◽  
Unpredictable Chronic Mild Stress

scholarly journals A Comparison of Isolation Stress and Unpredictable Chronic Mild Stress for the Establishment of Mouse Models of Depressive Disorder

2021 ◽  
Vol 14 ◽  
Author(s):  
Jin-Seok Lee ◽  
Ji-Yun Kang ◽  
Chang-Gue Son
Keyword(s):  
Animal Models ◽  
Depressive Disorder ◽  
Depressive Disorders ◽  
Chronic Mild Stress ◽  
Tail Suspension Test ◽  
Modern Society ◽  
Mild Stress ◽  
Isolation Stress ◽  
Unpredictable Chronic Mild Stress ◽  
Serum Corticosterone

This study aimed to help to understand the influence of stress on depression, which reflects the social environments of especially solitary life and the increasing prevalence of depressive disorders. To determine the distinguishable features of two-representative animal models of stress-induced depressive disorder, we compared isolation stress (IS) and unpredictable chronic mild stress (UCMS). After 4-week of stress, both models showed significant depressive- and anxiety-like behaviors in an open field test (OFT; p < 0.01 for IS, p < 0.01 for UCMS), forced swimming test (FST; p < 0.01 for IS, p < 0.01 for UCMS), and tail suspension test (TST; p < 0.01 for IS, p < 0.05 for UCMS) along with alterations in serum corticosterone levels, serotonin activity in the dorsal raphe nuclei (DRN) and microglial activity in the dentate gyrus of the hippocampus (p < 0.05 for both parameters). In a comparison of the two stress models, IS strongly induced depressive and anxiety features, as indicated by all parameters: behavior test scores (p < 0.05 for OFT, FST, and TST), serum corticosterone levels (p < 0.05), immunohistological alterations for serotonin activity (p < 0.05) and microglial activity (p = 0.072). Our results indicate the suitability of IS for the development of animal models of depressive disorders and may reveal the medical impact of social isolation environment in modern society.

scholarly journals The Antidepressive and Anxiolytic Effects of Formula Consisted of Poria cocos and Cordyceps militaris Waster Medium Extract in Unpredictable Chronic Mild Stress Animal Model

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1212-1212
Author(s):  
Huai-Syuan Huang ◽  
Hsin-Yu Wu ◽  
Wan-Ting Chang ◽  
Yu-En Lin ◽  
Yun-Ju Huang ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
P38 Mapk ◽  
Chronic Mild Stress ◽  
Cordyceps Militaris ◽  
Sucrose Preference ◽  
Mild Stress ◽  
Depression And Anxiety ◽  
Fruiting Bodies ◽  
Poria Cocos ◽  
Unpredictable Chronic Mild Stress

Abstract Objectives According to the WHO report, depression will be the first of the global burden of diseases in 2030. There is more than fifty % of people suffered from depression and anxiety. However, only less than half of the patients receive appropriate treatments due to its side effects of the antidepressants and anxiolytics. Poria cocos (PC) and Cordyceps militaris (CM) are historically used as a complementary therapy to treat depression and anxiety because of its anti-inflammation ability. Instead of fruiting bodies, C. militaris waster medium (CMWM) is a by-product and containing a higher amount of cordycepin than fruiting bodies. Thus, this study aims to investigate the anti-depressive and anti-anxiety effects of extract formula (PC-CMWM) via the regulation of inflammation pathways. Methods Unpredictable chronic mild stress (UCMS) model was used in this study to induce depression-like and anxiety-like behaviors in rats. The 6 weeks-old male Sprague Dawley rats were divided into five groups: control (CTL), UCMS-vehicle (NCTL), and three PC-CMWM groups (low, medium, and high dosage). The sucrose preference test and elevated plus maze (EPM) were preformed after UCMS for 35 days. The neurotransmitters (serotonin and dopamine) were measured by HPLC. The pro-inflammatory cytokines IL-1β and glutamate in the amygdala and serum were analyzed, and the proteins of p38 MAPK and NF-κB related to inflammation were evaluated by western blotting. Results PC-CMWM reversed the behavioral deficiency induced by UCMS exposure, including body weight loss, food intake, and sucrose preference compared to NCTL group (P < 0.05). In the EPM analysis, rats supplemented with PC-CMWM significantly increased the time spent in open arm than those in NCTL (P < 0.05). Besides, treatment with PC-CMWM significantly reduced glutamate in the amygdala and metabolic of serotonin and dopamine in the prefrontal cortex (P < 0.05) compared with NCTL. PC-CMWM improved the IL-1β in serum and reduced p38 MAPK and NF-κB protein expression in the prefrontal cortex (P < 0.05) compared with that in NCTL rats. Conclusions PC-CMWM exhibited anti-depressive and anxiolytic effects via reducing inflammation and modulating neurotransmitters and it can be used as a functional food to prevent depression and anxiety. Funding Sources TARI1073027.

Fluoxetine Effect on Aortic Nitric Oxide-Dependent Vasorelaxation in the Unpredictable Chronic Mild Stress Model of Depression in Mice

2012 ◽  
Vol 74 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Elsa Isingrini ◽  
Catherine Belzung ◽  
Jean-Louis Freslon ◽  
Marie-Christine Machet ◽  
Vincent Camus
Keyword(s):  
Nitric Oxide ◽  
Chronic Mild Stress ◽  
Mild Stress ◽  
Stress Model ◽  
Unpredictable Chronic Mild Stress
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