Prevalence and Burden of at-Risk Criteria of Psychosis and Help-Seeking Behaviour - a Population Survey

2011 ◽  
Vol 26 (S2) ◽  
pp. 1128-1128
Author(s):  
F. Schultze-Lutter ◽  
C. Michel ◽  
B. Schimmelmann

ObjectiveIn the discussion of the inclusion of an at-risk syndrome of psychosis in DSM-V, the validity of current at-risk criteria had been questioned based on studies reporting much higher prevalence rates of psychotic-like experiences in general population samples (GPS) compared to psychotic disorders. Thus the 3-month prevalence of at-risk criteria and symptoms in GPS, age 16–35, was assessed by trained clinicians in telephone interviews using established standardized assessments.MethodsOf 85 enrolled persons, 60 persons (70.5%) participated, two of them met exclusion criteria (psychosis, language problems). The 22 psychopathological at-risk symptoms were assessed for their occurrence and severity within the three months prior to the telephone interview using the(i)Schizophrenia Prediction Instrument, Adult version (SPI-A) and(ii)the Structured Interview for Prodromal Syndromes (SIPS).ResultsOnly one person (1.7%) fulfilled ‘attenuated psychotic symptoms’ (APS)-criteria according to SIPS. At 1.7%, the 3-month prevalence of at-risk criteria was rather low; at 20.7%, the prevalence of sub-threshold at-risk symptoms, however, was much higher. Yet the presence of these sub-threshold symptoms was already associated with lower psychosocial functioning and with psychiatric axis I diagnoses.

2010 ◽  
Vol 117 (2-3) ◽  
pp. 313-314
Author(s):  
Chantal Michel ◽  
Benno G. Schimmelmann ◽  
Noemi Schaffner ◽  
Frauke Schultze-Lutter

2012 ◽  
Vol 43 (7) ◽  
pp. 1365-1376 ◽  
Author(s):  
D. Koren ◽  
N. Reznik ◽  
M. Adres ◽  
R. Scheyer ◽  
A. Apter ◽  
...  

BackgroundThe goal of this study was to explore the notion that anomalies of self-experience (ASE) are a core, ‘not-yet-psychotic’ clinical phenotype of emerging schizophrenia and its spectrum.MethodTo accomplish this goal, we examined the relationship between ASE and commonly accepted risk markers in a sample of 87 help-seeking, non-psychotic adolescents (aged 14–18 years). ASE were assessed with the Examination of Anomalous Self-Experience (EASE), subclinical psychotic symptoms were assessed with the Prodromal Questionnaire and the Structured Interview for Prodromal Syndromes, deterioration in psychosocial functioning was assessed with the Social and Role Functioning Scales, and level of distress with the Mood and Anxiety Symptoms Questionnaire.ResultsAbout 82 participants completed the entire EASE interview. The number of participants who reported ASE at a clinically meaningful level (n = 18, 22%) was smaller than that who met diagnostic criteria for a prodromal syndrome (n = 28, 34%). The degree of overlap between the two conditions was moderate but statistically significant (χ2(1) = 7.01, p = 0.008). An exploratory factor analysis revealed that ASE load on a different factor than prodromal symptoms and deterioration in functioning, but that there is a moderate correlation between the three factors.ConclusionsThese results suggest that ASE are prevalent among non-psychotic help-seeking adolescents, yet at a considerably lower rate than prodromal symptoms. In addition, they suggest that ASE and prodromal symptoms constitute distinct but moderately related dimensions of potential risk. Taken together, they provide preliminary support for the clinical usefulness of supplementing and refining the methods of early detection of risk with assessment of ASE.


2010 ◽  
Vol 117 (2-3) ◽  
pp. 313
Author(s):  
Chantal Michel ◽  
Benno G. Schimmelmann ◽  
Noemi Schaffner ◽  
Frauke Schultze-Lutter

2010 ◽  
Vol 117 (2-3) ◽  
pp. 428-429 ◽  
Author(s):  
Frauke Schultze-Lutter ◽  
Chantal Michel ◽  
Noemi Schaffner ◽  
Benno G. Schimmelmann

2017 ◽  
Vol 41 (S1) ◽  
pp. S84-S84
Author(s):  
F. Schultze-Lutter ◽  
C. Michel ◽  
B.G. Schimmelmann ◽  
D. Hubl

IntroductionCompared to 16–40-year-olds, 8–15-year-olds of the community reported higher frequencies of perceptual and lesser clinical significance of non-perceptual attenuated psychotic symptoms (APS).Objectives/aimsWe examined if a similar age effect is present in a clinical never-psychotic sample (n = 133) referred to a specialized service for clinical suspicion of developing psychosis.MethodsAPS and brief intermittent psychotic symptoms (BIPS) were assessed using items P1-3 and P5 (non-perceptual) and P4 (perceptual) of the structured interview for psychosis-risk syndromes, current axis-I disorders with the mini-international neuropsychiatric interview and psychosocial functioning with the Social and Occupational Functioning Assessment Scale (score < 71 indicative of at least some difficulty in social, occupational, or school functioning).ResultsOverall, 64% reported APS (61%) or BIPS (7%); any perceptual APS/BIPS was reported by 43% and any non-perceptual APS/BIPS by 44%. In correspondence to the results of the community study, perceptual but not non-perceptual APS/BIPS were significantly more frequent in younger age groups below the age of 16 (8–12 yrs: OR = 4.7 (1.1–19.5); 13–15 yrs: OR = 2.7 (0.9–7.7); 20–24-year-olds as reference group). An age effect of APS/BIPS on presence of any current axis-I disorder (59%) or functional difficulties (67%) could not be detected. Yet, when APS onset requirements were met, the likelihood of a psychiatric diagnosis increased significantly with advancing age.ConclusionOverall, the replicated age effect on perceptual APS in this clinical sample highlights the need to examine ways to distinguish clinically relevant perceptual APS from perceptual aberrations likely remitting over the course of adolescence.Disclosure of interestThe authors have not supplied their declaration of competing interest.


2010 ◽  
Vol 117 (2-3) ◽  
pp. 200-201
Author(s):  
Chantal Michel ◽  
Frauke Schultze-Lutter ◽  
Noemi Schaffner ◽  
Schimmelmann G. Benno

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